DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-7 and Cd180

DIOPT Version :9

Sequence 1:	NP_523797.1	Gene:	Toll-7 / 37272	FlyBaseID:	FBgn0034476	Length:	1446	Species:	Drosophila melanogaster
Sequence 2:	NP_001099875.1	Gene:	Cd180 / 294706	RGDID:	1308170	Length:	662	Species:	Rattus norvegicus

Alignment Length:	652	Identity:	141/652 - (21%)
Similarity:	257/652 - (39%)	Gaps:	147/652 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   186 GGLKQLTD-LDLGDNNLRQLPSGFLCPVGNLQVLNLTRNRIRTAEQMGFADMNCGAGSGSAGSEL 249
            |.|...|: |:...|.|..:.......:.||..|:|||.:|....:..|...:          .|
  Rat    49 GTLPNSTESLEFSFNALPTIQKTTFSRLVNLTFLDLTRCQIYWIHEDTFQSQH----------RL 103

  Fly   250 QVLDASHNELRSISESWGISRLRRLQHLNLAYNNLSELSGEALAGLASLRIVNLSNNHLET--LP 312
            :.|..:.|.|..::|: .::..:.|:||......:|.:....:....:|..:.|.:||:.:  ||
  Rat   104 ETLVLTANPLIFMAET-ALTGPKALKHLFFIQTGISSIEFIPVHSQKALESLYLGSNHISSIRLP 167

  Fly   313 EGLFAGSKELREIHLQQNELYELPKGLFHRLEQL--LVVDLSGNQLT--------SNHVDNTTFA 367
            :..  .:::|:.:..|.|.::.|.|.....|:|.  |.::|:||.:|        |....:..|.
  Rat   168 KDF--PTEKLKVLDFQNNAIHHLSKEDVSSLQQATNLSLNLNGNDITGIEPGAFKSTVFQSLNFG 230

  Fly   368 GLIRLIVL--NLAHNALTRIDYRTFKEL----------------YFLQILNLRNNSIGHIEDNAF 414
            |...|:|:  .|.::.:..:...||:::                ..::.:||:.:...:|..|.|
  Rat   231 GTQSLLVIFKGLQNSTIQSLWLGTFEDIDDDEDISSSMFEGLCEMSVERINLQKHHFFNITSNTF 295

  Fly   415 LPLYNLHTLNLAENRLHTLDDKLFNGLYVLSKLTLNNNL---ISVVEPAVFKNCSDL------KE 470
            .....|..|:|....|..|...:. ||..|.||.|:.|.   :..:..:.|.:.:.|      |.
  Rat   296 YCFSGLQELDLTATHLTELPSGIV-GLSKLKKLVLSANKFENLCQISASNFPSLTHLYIKGNTKR 359

  Fly   471 LDLSSNQLNEVPRALQDLAMLRTLDLGENQIRTFD--NQSFKNLHQLTGLRLIDNQIGNITVGMF 533
            |:|.|.       .|:.|..||.|||..:.|.|.|  |...:||..|..|.|..|:...:....|
  Rat   360 LELGSG-------CLETLEHLRELDLSHDDIETSDCCNLQLRNLSHLQSLNLSYNEPLGLRTEAF 417

  Fly   534 QDLPRLSVLNLAKNRIQSIERGSFDKNFELEAIRLDRNFLADINGVFATLVSLLWLNL------- 591
            ::.|:|.:|:||..|:.                      :.|....|..|..|..|||
  Rat   418 KECPQLELLDLAFTRLH----------------------VKDAQSPFQNLHLLKVLNLSHCLLGS 460

  Fly   592 SENHLVWFDYAFIPSNLKWLDIHGNYIEALGNYYKLQEEIRVKTLDASHNRITEIGPMSIPNTIE 656
            |..||:    ..:|: |:.|::.||..                    .:..|.:..|:....::|
  Rat   461 SNQHLL----DGLPA-LRHLNLQGNRF--------------------PNGNIQKTNPLQALGSLE 500

  Fly   657 LLFINNNLIGNVQPNAFVDKANLARVDLYANQLSKLQLQQL-------------RVAPVVAPKPL 708
            :|.::...:.::...||::...:..|||..|:|:...::.|             |:: ::.|..|
  Rat   501 ILILSFCDLSSIDHQAFINLKIMNHVDLSHNRLTSSSIEALSHLKGIYLNLASNRIS-IIPPSLL 564

  Fly   709 P------EFYLGGNPFECDCT----MDW----LQRINNL--TTRQHPRVMDMANIECVMPHARGA 757
            |      ...|..||.:|.|:    ::|    :|::.::  |...:|.::....:..||.....|
  Rat   565 PVLSQQRTINLRQNPLDCTCSNIYFLEWYKENMQKLEDIEDTFCANPPLLRGVKVSDVMLSCSMA 629

  Fly   758 AV 759
            ||
  Rat   630 AV 631

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-7	NP_523797.1	LRR_8	135..201	CDD:290566	5/15 (33%)
		leucine-rich repeat	136..159	CDD:275380
		leucine-rich repeat	160..190	CDD:275380	2/3 (67%)
		LRR_8	189..259	CDD:290566	15/70 (21%)
		leucine-rich repeat	191..214	CDD:275380	4/23 (17%)
		leucine-rich repeat	215..248	CDD:275380	7/32 (22%)
		LRR_RI	247..501	CDD:238064	65/292 (22%)
		LRR_8	247..308	CDD:290566	12/60 (20%)
		leucine-rich repeat	249..273	CDD:275380	5/23 (22%)
		leucine-rich repeat	274..297	CDD:275380	4/22 (18%)
		LRR_8	297..356	CDD:290566	17/62 (27%)
		leucine-rich repeat	298..321	CDD:275380	6/24 (25%)
		leucine-rich repeat	322..345	CDD:275380	6/22 (27%)
		LRR_8	345..406	CDD:290566	16/88 (18%)
		leucine-rich repeat	346..371	CDD:275380	8/34 (24%)
		leucine-rich repeat	372..395	CDD:275380	5/40 (13%)
		leucine-rich repeat	396..419	CDD:275380	5/22 (23%)
		LRR_8	419..478	CDD:290566	18/67 (27%)
		leucine-rich repeat	420..443	CDD:275380	7/22 (32%)
		leucine-rich repeat	444..467	CDD:275380	6/25 (24%)
		LRR_RI	466..622	CDD:238064	44/170 (26%)
		leucine-rich repeat	468..488	CDD:275380	6/25 (24%)
		LRR_8	491..549	CDD:290566	21/59 (36%)
		leucine-rich repeat	491..514	CDD:275380	11/24 (46%)
		leucine-rich repeat	515..536	CDD:275380	5/20 (25%)
		leucine-rich repeat	539..562	CDD:275380	5/22 (23%)
		leucine-rich repeat	563..585	CDD:275380	3/21 (14%)
		leucine-rich repeat	586..626	CDD:275380	12/46 (26%)
		leucine-rich repeat	627..653	CDD:275380	2/25 (8%)
		LRRCT	716..772	CDD:214507	13/54 (24%)
		LRRNT	796..830	CDD:214470
		leucine-rich repeat	812..829	CDD:275380
		leucine-rich repeat	833..854	CDD:275380
		LRR_8	853..913	CDD:290566
		leucine-rich repeat	855..878	CDD:275380
		LRR_4	878..918	CDD:289563
		leucine-rich repeat	879..902	CDD:275380
		leucine-rich repeat	903..926	CDD:275380
		leucine-rich repeat	927..953	CDD:275380
		TIR	1098..1235	CDD:214587
Cd180	NP_001099875.1	leucine-rich repeat	55..78	CDD:275380	4/22 (18%)
		leucine-rich repeat	79..102	CDD:275380	7/32 (22%)
		leucine-rich repeat	103..126	CDD:275380	5/23 (22%)
		leucine-rich repeat	127..150	CDD:275380	4/22 (18%)
		leucine-rich repeat	151..174	CDD:275380	6/24 (25%)
		leucine-rich repeat	175..195	CDD:275380	5/19 (26%)
		leucine-rich repeat	196..223	CDD:275380	8/26 (31%)
		leucine-rich repeat	224..244	CDD:275380	5/19 (26%)
		leucine-rich repeat	277..300	CDD:275380	5/22 (23%)
		LRR_RI	301..480	CDD:238064	55/213 (26%)
		leucine-rich repeat	301..323	CDD:275380	7/22 (32%)
		LRR_8	322..383	CDD:290566	18/67 (27%)
		leucine-rich repeat	324..347	CDD:275380	6/22 (27%)
		leucine-rich repeat	348..372	CDD:275380	7/30 (23%)
		LRR_8	372..433	CDD:290566	21/60 (35%)
		leucine-rich repeat	373..398	CDD:275380	11/24 (46%)
		leucine-rich repeat	399..422	CDD:275380	5/22 (23%)
		LRR_8	421..482	CDD:290566	21/87 (24%)
		leucine-rich repeat	423..447	CDD:275380	8/45 (18%)
		leucine-rich repeat	448..471	CDD:275380	7/26 (27%)
		leucine-rich repeat	472..498	CDD:275380	6/45 (13%)
		LRR_8	498..556	CDD:290566	10/57 (18%)
		leucine-rich repeat	499..522	CDD:275380	4/22 (18%)
		leucine-rich repeat	523..546	CDD:275380	6/22 (27%)
		TPKR_C2	578..627	CDD:301599	10/48 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010