DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Toll-7 and Chad

DIOPT Version :9

Sequence 1:	NP_523797.1	Gene:	Toll-7 / 37272	FlyBaseID:	FBgn0034476	Length:	1446	Species:	Drosophila melanogaster
Sequence 2:	NP_062037.1	Gene:	Chad / 29195	RGDID:	2336	Length:	358	Species:	Rattus norvegicus

Alignment Length:	264	Identity:	85/264 - (32%)
Similarity:	121/264 - (45%)	Gaps:	24/264 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   194 LDLGDNNLRQLPSGFLCPVGNLQVLNLTRNRIRTAEQMGFADMNCGAGSGSAGSELQVLDASHNE 258
            |:|..||...|.:.....|.||..|:|....||          ...||:.....:|..|..|||:
  Rat    55 LNLQRNNFPVLAANSFRTVPNLVSLHLQHCNIR----------EVAAGAFRGLKQLIYLYLSHND 109

  Fly   259 LRSISESWGISRLRRLQHLNLAYNNLSELSGEALAGLASLRIVNLSNNHLETLPEGLFAGSKELR 323
            :| :..:.....|..|.:|.|.:|.:|||....|:.|.:|.|:.|:||.:..|..|.|.|:|:||
  Rat   110 IR-VLRAGAFDDLTELTYLYLDHNKVSELPRGLLSPLVNLFILQLNNNKIRELRAGAFQGAKDLR 173

  Fly   324 EIHLQQNELYELPKGLFHRLEQLLVVDLSGNQLTSNHVDNTTFAGLIRLIV---LNLAHNALTRI 385
            .::|.:|.|..|..|....:|.|....|..|||:|     ...|.|.:|.|   |.|:||.|..|
  Rat   174 WLYLSENALTSLHPGSLDDVENLAKFHLDRNQLSS-----YPSAALSKLRVVEELKLSHNPLKSI 233

  Fly   386 DYRTFKEL-YFLQILNLRNNSIGHIEDNAFLPLYNLHTLNLAENRLHTLDDKL-FNGLYVLSKLT 448
            ....|:.. .:|:.|.|.|.::....|.||..:..|..::|..|||:.|.... |:.   |..||
  Rat   234 PDNAFQSFGRYLETLWLDNTNLEKFSDAAFAGVTTLKHVHLENNRLNQLPSTFPFDN---LETLT 295

  Fly   449 LNNN 452
            |.||
  Rat   296 LTNN 299

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-7	NP_523797.1	LRR_8	135..201	CDD:290566	3/6 (50%)
		leucine-rich repeat	136..159	CDD:275380
		leucine-rich repeat	160..190	CDD:275380
		LRR_8	189..259	CDD:290566	19/64 (30%)
		leucine-rich repeat	191..214	CDD:275380	6/19 (32%)
		leucine-rich repeat	215..248	CDD:275380	7/32 (22%)
		LRR_RI	247..501	CDD:238064	71/211 (34%)
		LRR_8	247..308	CDD:290566	21/60 (35%)
		leucine-rich repeat	249..273	CDD:275380	7/23 (30%)
		leucine-rich repeat	274..297	CDD:275380	9/22 (41%)
		LRR_8	297..356	CDD:290566	21/58 (36%)
		leucine-rich repeat	298..321	CDD:275380	9/22 (41%)
		leucine-rich repeat	322..345	CDD:275380	7/22 (32%)
		LRR_8	345..406	CDD:290566	21/64 (33%)
		leucine-rich repeat	346..371	CDD:275380	8/24 (33%)
		leucine-rich repeat	372..395	CDD:275380	9/26 (35%)
		leucine-rich repeat	396..419	CDD:275380	7/22 (32%)
		LRR_8	419..478	CDD:290566	13/35 (37%)
		leucine-rich repeat	420..443	CDD:275380	7/23 (30%)
		leucine-rich repeat	444..467	CDD:275380	6/9 (67%)
		LRR_RI	466..622	CDD:238064
		leucine-rich repeat	468..488	CDD:275380
		LRR_8	491..549	CDD:290566
		leucine-rich repeat	491..514	CDD:275380
		leucine-rich repeat	515..536	CDD:275380
		leucine-rich repeat	539..562	CDD:275380
		leucine-rich repeat	563..585	CDD:275380
		leucine-rich repeat	586..626	CDD:275380
		leucine-rich repeat	627..653	CDD:275380
		LRRCT	716..772	CDD:214507
		LRRNT	796..830	CDD:214470
		leucine-rich repeat	812..829	CDD:275380
		leucine-rich repeat	833..854	CDD:275380
		LRR_8	853..913	CDD:290566
		leucine-rich repeat	855..878	CDD:275380
		LRR_4	878..918	CDD:289563
		leucine-rich repeat	879..902	CDD:275380
		leucine-rich repeat	903..926	CDD:275380
		leucine-rich repeat	927..953	CDD:275380
		TIR	1098..1235	CDD:214587
Chad	NP_062037.1	LRRNT	22..48	CDD:279764
		LRR 1	51..72		5/16 (31%)
		leucine-rich repeat	52..75	CDD:275380	6/19 (32%)
		LRR_8	74..134	CDD:290566	19/70 (27%)
		LRR 2	75..96		8/30 (27%)
		leucine-rich repeat	76..99	CDD:275380	7/32 (22%)
		LRR_RI	<89..281	CDD:238064	65/197 (33%)
		LRR 3	99..120		6/21 (29%)
		leucine-rich repeat	100..123	CDD:275380	7/23 (30%)
		LRR 4	123..144		8/20 (40%)
		leucine-rich repeat	124..147	CDD:275380	9/22 (41%)
		LRR_8	147..206	CDD:290566	21/58 (36%)
		LRR 5	147..168		8/20 (40%)
		leucine-rich repeat	148..171	CDD:275380	9/22 (41%)
		LRR 6	171..192		7/20 (35%)
		leucine-rich repeat	172..195	CDD:275380	7/22 (32%)
		LRR_8	195..255	CDD:290566	21/64 (33%)
		LRR 7	195..216		8/25 (32%)
		leucine-rich repeat	196..219	CDD:275380	9/27 (33%)
		LRR 8	219..240		8/20 (40%)
		leucine-rich repeat	220..243	CDD:275380	7/22 (32%)
		LRR_8	243..300	CDD:290566	20/60 (33%)
		LRR 9	244..265		7/20 (35%)
		leucine-rich repeat	245..268	CDD:275380	7/22 (32%)
		LRR 10	268..289		6/20 (30%)
		LRRCT	299..346	CDD:214507	1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	321..358
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.100