DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-7 and Slitrk6

DIOPT Version :9

Sequence 1:	NP_523797.1	Gene:	Toll-7 / 37272	FlyBaseID:	FBgn0034476	Length:	1446	Species:	Drosophila melanogaster
Sequence 2:	NP_001099527.1	Gene:	Slitrk6 / 290467	RGDID:	1306550	Length:	840	Species:	Rattus norvegicus

Alignment Length:	975	Identity:	192/975 - (19%)
Similarity:	317/975 - (32%)	Gaps:	347/975 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   375 LNLAHNALTRIDYRTFKELYFLQILNLRNNSIGHIEDNAFLPLYNLHTLNLAENRLHTLDDKLFN 439
            |:|.:|.||.:....|..|.....::|..|:|..||..||..|..|..|::..|.|..|.:..|:
  Rat    69 LSLLNNGLTTLHTNDFSGLTNALSIHLGFNNIADIETGAFNGLGLLKQLHINHNSLEILKEDTFH 133

  Fly   440 GLYVLSKLTLNNNLISVVEPAVFKNCSDLKELDLSSNQLNEVPRALQDLAMLRTLDLGENQIRTF 504
            ||..|..|..:||.|:|:|.:.|...:.||.|.|:.|.:..:|..:.....|..|||..||::|.
  Rat   134 GLENLEFLQADNNFITVIEQSAFSKLNRLKVLILNDNAIESLPPNIFRFVPLTHLDLRGNQLQTL 198

  Fly   505 DNQSF-KNLHQLTGLRLIDN---------QIGNITVGMFQDLPRLSVLN--------LAKNRIQS 551
            ....| :::.::..|:|.||         |:.|    ..:::|..|::.        |.|..|.|
  Rat   199 PYVGFLEHIGRILDLQLEDNKWACNCELLQLKN----WLENMPPQSIIGDVICYSPPLFKGSILS 259

  Fly   552 IERGSFDKNFELEAIRLDRNFLADINGVFATLVSLLWLNLSENHLVWFDYAFIPSNLKWLDIHGN 616
                           ||.:..:.....|:            |.|               .|..|:
  Rat   260 ---------------RLKKESICPTPPVY------------EEH---------------EDPAGS 282

  Fly   617 YIEALGNYYKLQEEIRVKTLDASHNRITEIGPMSIPNTIELLFINNNLIGNVQPNAFVDKANLAR 681
            .:..              |...|.:|::.               .|..|
  Rat   283 LLAI--------------TSSTSDSRLSS---------------KNTSI---------------- 302

  Fly   682 VDLYANQLSKLQLQQLRVAPVVAP---KPLPEFYLGGNPFECDCTMDWLQRINNLTTRQHPRVMD 743
                        |:|...||...|   ||..:..:...|..|:|                 :|:.
  Rat   303 ------------LKQPTKAPGSVPYLTKPSTQLPVPYCPVPCNC-----------------KVLS 338

  Fly   744 MANIECVMPHARGAAVRPLSGLRPQDFLCRYESHCFALCHCCDFDACDCEMTCPSNCTCYHDQIW 808
            .:.:   :.|.:...:..:|.|:|.                            |.|
  Rat   339 PSGL---LIHCQERNIESVSDLQPP----------------------------PHN--------- 363

  Fly   809 STNVVDCGGQQTTELPRRVPMDSSVV-----------------YLDGNNFPVLKNHAFIGRKNLR 856
                           ||::.:..:::                 :|..|...||:..:|:....|:
  Rat   364 ---------------PRKLILAGNIIHTLMKADLMDYFTLEMLHLGNNRIEVLEEGSFMNLTRLQ 413

  Fly   857 ALYVNGSQVAAIQNRTFASLASLQLLHLADNKLRTLHGYEFEQLSALRELYLQNNQLTTIENATL 921
            .||:||:.:..:....|..|:||:.|:|..|.::.:....|..:..|:.|||.||.|..:. |.:
  Rat   414 KLYLNGNHLTKLYKGMFLGLSSLEYLYLEYNAVKEILPGTFNPMPKLKVLYLNNNLLHVLP-AHI 477

  Fly   922 APLAALELIRIDGNRLVTLPIWQMHATHFGTRLKSISLGRNQWSCRCQFLQALTSYVADNALIVQ 986
            .....|..:.:..|:...||:  .:.......|..|.|..|.|.|.|. |..|..::
  Rat   478 FLGIPLTRVNLKTNQFTHLPV--SNILDDLDLLIQIDLEDNPWDCSCD-LVGLQQWI-------- 531

  Fly   987 DAQDIYCMAASSGTGSAALEDSSSNSGSLEKRELDFNATGAACTDYYSGGSMLQHGIPESYI--- 1048
                     ...|.|:...:...::.|.|:|:||....:...|....:..||   ....|||
  Rat   532 ---------HKLGKGTVTDDILCASPGHLDKKELKALNSELLCPGLVNNPSM---PTQTSYIIVT 584

  Fly  1049 -PLLAA-----------------ALALLFLLVVIAMVFA-------------------FRESLRI 1076
             |.:||                 .|.|..|:|.|.:||.                   ..|.||.
  Rat   585 SPTMAADAAGTLLSSLTDAVPLSVLILGLLIVFITIVFCAAGIVVFVLHRRRRYKKKKVEEQLRD 649

  Fly  1077 WLFAHYGVRVFGPRC------EESEKLYD----AVLLHSAKDSEFVCQHLAAQLETGRPPLRVCL 1131
            ....|....::|.:.      ..|..||:    :.::|..:...|..:||....|.....
  Rat   650 TSPVHLQYSMYGHKTTHHTTERPSSSLYEQHMVSPMVHVYRSPSFGPKHLEEVEERSDKE----- 709

  Fly  1132 QHRDLAHDATHYQ--LLE--------ATRVSRRVV------------ILLTRNFLQ--------- 1165
                 .:||.|.|  |||        .:.:..:||            .||.||.|.
  Rat   710 -----GNDAKHLQRSLLERENHSPLTGSNMKYKVVDQSTDFLPFQDASLLYRNILDKERELQQLG 769

  Fly  1166 -TEWAR---CELRRSV-------HDALR-------GRPQKLVIIEEPEVAFEAESDIELLP-YLK 1211
             ||:.|   .:|:..|       |:.|:       .||:|:::.:.....||.::::...| ||:
  Rat   770 ITEYLRKNIAQLQPDVEVNYPGAHEELKLMETLMYSRPRKVLVEQTKNEYFELKANLHAEPDYLE 834

Fly 1212 1211
Rat 835 834

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-7	NP_523797.1	LRR_8	135..201	CDD:290566
		leucine-rich repeat	136..159	CDD:275380
		leucine-rich repeat	160..190	CDD:275380
		LRR_8	189..259	CDD:290566
		leucine-rich repeat	191..214	CDD:275380
		leucine-rich repeat	215..248	CDD:275380
		LRR_RI	247..501	CDD:238064	42/125 (34%)
		LRR_8	247..308	CDD:290566
		leucine-rich repeat	249..273	CDD:275380
		leucine-rich repeat	274..297	CDD:275380
		LRR_8	297..356	CDD:290566
		leucine-rich repeat	298..321	CDD:275380
		leucine-rich repeat	322..345	CDD:275380
		LRR_8	345..406	CDD:290566	9/30 (30%)
		leucine-rich repeat	346..371	CDD:275380
		leucine-rich repeat	372..395	CDD:275380	7/19 (37%)
		leucine-rich repeat	396..419	CDD:275380	8/22 (36%)
		LRR_8	419..478	CDD:290566	21/58 (36%)
		leucine-rich repeat	420..443	CDD:275380	8/22 (36%)
		leucine-rich repeat	444..467	CDD:275380	8/22 (36%)
		LRR_RI	466..622	CDD:238064	33/173 (19%)
		leucine-rich repeat	468..488	CDD:275380	6/19 (32%)
		LRR_8	491..549	CDD:290566	18/75 (24%)
		leucine-rich repeat	491..514	CDD:275380	8/23 (35%)
		leucine-rich repeat	515..536	CDD:275380	6/29 (21%)
		leucine-rich repeat	539..562	CDD:275380	5/30 (17%)
		leucine-rich repeat	563..585	CDD:275380	3/21 (14%)
		leucine-rich repeat	586..626	CDD:275380	4/39 (10%)
		leucine-rich repeat	627..653	CDD:275380	3/25 (12%)
		LRRCT	716..772	CDD:214507	8/55 (15%)
		LRRNT	796..830	CDD:214470	4/33 (12%)
		leucine-rich repeat	812..829	CDD:275380	2/16 (13%)
		leucine-rich repeat	833..854	CDD:275380	5/37 (14%)
		LRR_8	853..913	CDD:290566	19/59 (32%)
		leucine-rich repeat	855..878	CDD:275380	7/22 (32%)
		LRR_4	878..918	CDD:289563	13/39 (33%)
		leucine-rich repeat	879..902	CDD:275380	5/22 (23%)
		leucine-rich repeat	903..926	CDD:275380	8/22 (36%)
		leucine-rich repeat	927..953	CDD:275380	4/25 (16%)
		TIR	1098..1235	CDD:214587	35/168 (21%)
Slitrk6	NP_001099527.1	leucine-rich repeat	68..89	CDD:275380	7/19 (37%)
		LRR_8	69..124	CDD:290566	18/54 (33%)
		leucine-rich repeat	94..113	CDD:275380	8/18 (44%)
		leucine-rich repeat	114..137	CDD:275380	8/22 (36%)
		LRR_8	137..195	CDD:290566	19/57 (33%)
		leucine-rich repeat	138..161	CDD:275380	8/22 (36%)
		leucine-rich repeat	162..177	CDD:275380	5/14 (36%)
		leucine-rich repeat	185..260	CDD:275380	20/93 (22%)
		leucine-rich repeat	210..222	CDD:275378	4/11 (36%)
		TPKR_C2	218..268	CDD:301599	11/68 (16%)
		leucine-rich repeat	261..411	CDD:275380	35/305 (11%)
		leucine-rich repeat	365..387	CDD:275380	1/21 (5%)
		LRR_8	387..444	CDD:290566	16/56 (29%)
		LRR_4	388..425	CDD:289563	10/36 (28%)
		LRR_4	410..449	CDD:289563	12/38 (32%)
		leucine-rich repeat	412..435	CDD:275380	7/22 (32%)
		LRR_8	434..493	CDD:290566	16/59 (27%)
		leucine-rich repeat	436..459	CDD:275380	5/22 (23%)
		leucine-rich repeat	460..481	CDD:275380	8/21 (38%)
		LRRCT	516..566	CDD:214507	13/67 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	182	1.000	Inparanoid score	I3875
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.050