DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-7 and Lrrn2

DIOPT Version :9

Sequence 1:	NP_523797.1	Gene:	Toll-7 / 37272	FlyBaseID:	FBgn0034476	Length:	1446	Species:	Drosophila melanogaster
Sequence 2:	NP_001170839.1	Gene:	Lrrn2 / 289020	RGDID:	1305482	Length:	750	Species:	Rattus norvegicus

Alignment Length:	501	Identity:	120/501 - (23%)
Similarity:	185/501 - (36%)	Gaps:	125/501 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   301 VNLSNNHLETLPEGLFAGSKELREIHLQQNELYELPKGLFHRLEQLLVVDLSGNQLTSNHVDNTT 365
            |:.::..|..:|.||.||::.|.   ||.|.:..:.:.....|..|..:|||.|..:.  ..:..
  Rat    53 VDCNDLFLTAVPPGLPAGTQTLL---LQSNSISRIEQTELGYLANLTELDLSQNSFSD--ARDCD 112

  Fly   366 FAGLIRLIVLNLAHNALTRIDYRTFKELYFLQILNLRNNSIGHIEDNAFLPLYNLHTLNLAENRL 430
            |..|.:|:.|:|..|.|:|::..:|..|..||.|.|.:|.:..|...||..|.||..|:|..|.|
  Rat   113 FQALPQLLSLHLEENQLSRLEDHSFAGLTRLQELYLNHNQLCRISPRAFEGLGNLLRLHLNSNLL 177

  Fly   431 HTLDDKLFNGLYVLSKLTLNNNLISVVEPAVFKNCSDLKELDLSSNQLNEVPRALQDLAMLRTLD 495
            .|:|.:.|..|..|..|.:..|.:..:             ||::          .:.||.||:|.
  Rat   178 RTIDSRWFEMLPNLEILMIGGNKVDAI-------------LDMN----------FRPLANLRSLV 219

  Fly   496 LGENQIRTFDNQSFKNLHQLTGLRLIDNQIGNITVGMFQDLPRLSVLNLAKNRIQSIERGSFDKN 560
            |....:|...:.:.:.|..|..|...|||:..:.....:.:|.|..|:|.||.:|.:..|.|...
  Rat   220 LAGMSLREISDYALEGLQSLESLSFYDNQLAQVPKRALEQVPGLKFLDLNKNPLQRVGPGDFANM 284

  Fly   561 FELEAIRLDRNFLADINGVFATLVSLLWLNLSENHLVWFD-YAFIPSNLKWLDIHGNYIEALGNY 624
            ..|:.:.|:                    |:.|  ||..| :|.:
  Rat   285 LHLKELGLN--------------------NMEE--LVSIDKFALV-------------------- 307

  Fly   625 YKLQEEIRVKTLDASHNRITEIGPMSIPNTIELLFINNNLIGNVQPNAFVDKANLARVDLYANQL 689
                                     ::|...:|...||..:..:.|.||.....:..:.|..|.|
  Rat   308 -------------------------NLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNAL 347

  Fly   690 SKLQLQQLRVAPVVAPKPLPEFYLGGNPFECDCTMDWLQRINNLTTRQHPRVMDMANIECVMP-- 752
            |.|..|.:...|     .|.|..|.|||..|||.:.|..     .|..|.|.::..:..|..|
  Rat   348 SALHQQTVESLP-----NLQEVGLHGNPIRCDCVIRWAN-----ATGTHVRFIEPQSTLCAEPPD 402

  Fly   753 ----HARGAAVRPLSG-----LRPQDF-----LCRYES---HCFAL 781
                ..|....|.::.     :.|:.|     :...||   ||.||
  Rat   403 LQRRPVREVPFREMTDHCLPLISPRSFPSSLQVASGESLVLHCRAL 448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-7	NP_523797.1	LRR_8	135..201	CDD:290566
		leucine-rich repeat	136..159	CDD:275380
		leucine-rich repeat	160..190	CDD:275380
		LRR_8	189..259	CDD:290566
		leucine-rich repeat	191..214	CDD:275380
		leucine-rich repeat	215..248	CDD:275380
		LRR_RI	247..501	CDD:238064	57/199 (29%)
		LRR_8	247..308	CDD:290566	1/6 (17%)
		leucine-rich repeat	249..273	CDD:275380
		leucine-rich repeat	274..297	CDD:275380
		LRR_8	297..356	CDD:290566	17/54 (31%)
		leucine-rich repeat	298..321	CDD:275380	7/19 (37%)
		leucine-rich repeat	322..345	CDD:275380	5/22 (23%)
		LRR_8	345..406	CDD:290566	20/60 (33%)
		leucine-rich repeat	346..371	CDD:275380	7/24 (29%)
		leucine-rich repeat	372..395	CDD:275380	8/22 (36%)
		leucine-rich repeat	396..419	CDD:275380	9/22 (41%)
		LRR_8	419..478	CDD:290566	15/58 (26%)
		leucine-rich repeat	420..443	CDD:275380	9/22 (41%)
		leucine-rich repeat	444..467	CDD:275380	3/22 (14%)
		LRR_RI	466..622	CDD:238064	32/156 (21%)
		leucine-rich repeat	468..488	CDD:275380	2/19 (11%)
		LRR_8	491..549	CDD:290566	17/57 (30%)
		leucine-rich repeat	491..514	CDD:275380	6/22 (27%)
		leucine-rich repeat	515..536	CDD:275380	5/20 (25%)
		leucine-rich repeat	539..562	CDD:275380	8/22 (36%)
		leucine-rich repeat	563..585	CDD:275380	2/21 (10%)
		leucine-rich repeat	586..626	CDD:275380	6/40 (15%)
		leucine-rich repeat	627..653	CDD:275380	0/25 (0%)
		LRRCT	716..772	CDD:214507	15/71 (21%)
		LRRNT	796..830	CDD:214470
		leucine-rich repeat	812..829	CDD:275380
		leucine-rich repeat	833..854	CDD:275380
		LRR_8	853..913	CDD:290566
		leucine-rich repeat	855..878	CDD:275380
		LRR_4	878..918	CDD:289563
		leucine-rich repeat	879..902	CDD:275380
		leucine-rich repeat	903..926	CDD:275380
		leucine-rich repeat	927..953	CDD:275380
		TIR	1098..1235	CDD:214587
Lrrn2	NP_001170839.1	LRR_RI	46..288	CDD:238064	73/262 (28%)
		leucine-rich repeat	51..69	CDD:275380	5/15 (33%)
		leucine-rich repeat	71..94	CDD:275380	5/25 (20%)
		leucine-rich repeat	95..118	CDD:275380	7/24 (29%)
		LRR_8	117..177	CDD:290566	22/59 (37%)
		leucine-rich repeat	119..142	CDD:275380	8/22 (36%)
		leucine-rich repeat	143..166	CDD:275380	9/22 (41%)
		LRR_8	166..222	CDD:290566	21/78 (27%)
		leucine-rich repeat	167..190	CDD:275380	9/22 (41%)
		leucine-rich repeat	191..214	CDD:275380	6/45 (13%)
		LRR_RI	214..>372	CDD:238064	48/229 (21%)
		LRR_8	214..273	CDD:290566	17/58 (29%)
		leucine-rich repeat	215..238	CDD:275380	6/22 (27%)
		leucine-rich repeat	239..262	CDD:275380	5/22 (23%)
		leucine-rich repeat	263..286	CDD:275380	8/22 (36%)
		leucine-rich repeat	287..311	CDD:275380	8/90 (9%)
		LRR_8	310..371	CDD:290566	19/65 (29%)
		leucine-rich repeat	312..334	CDD:275380	6/21 (29%)
		leucine-rich repeat	337..360	CDD:275378	7/27 (26%)
		leucine-rich repeat	361..373	CDD:275378	6/11 (55%)
		TPKR_C2	369..412	CDD:301599	12/47 (26%)
		I-set	430..514	CDD:254352	6/19 (32%)
		Ig	438..514	CDD:299845	6/11 (55%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010