DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Toll-7 and Tlr13

DIOPT Version :9

Sequence 1:NP_523797.1 Gene:Toll-7 / 37272 FlyBaseID:FBgn0034476 Length:1446 Species:Drosophila melanogaster
Sequence 2:NP_991389.1 Gene:Tlr13 / 279572 MGIID:3045213 Length:991 Species:Mus musculus


Alignment Length:1119 Identity:241/1119 - (21%)
Similarity:415/1119 - (37%) Gaps:349/1119 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   259 LRSISESWGISRLRR----LQHLNLAYNNLSELSGEALAGLASLRI-VNLSNNHLETLPEGLFAG 318
            |..::|::|.::..:    :.|:......::.|: ||::.:..... :||::|.::.||...|..
Mouse    62 LPPVAETYGFNKCTQYEFDIHHVLCIRKKITNLT-EAISDIPRYTTHLNLTHNEIQVLPPWSFTN 125

  Fly   319 SKELREIHLQQNELYELPKGLFHRLEQLLVVDLSGNQLTSNHVDNTTFAGLIRLIVLNLAHNALT 383
            ...|.::.|:.|.::::.:|.|..||.|.:::|..|::.|   .|.:|.||..|..|.|:||.:|
Mouse   126 LSALVDLRLEWNSIWKIDEGAFRGLENLTLLNLVENKIQS---VNNSFEGLSSLKTLLLSHNQIT 187

  Fly   384 RIDYRTFKELYFLQILNLRNNSI----GHIEDNAFLP---------------------LYNLHTL 423
            .|....|..|..|:.|:|..|:|    |.:|....||                     |.:|..|
Mouse   188 HIHKDAFTPLIKLKYLSLSRNNISDFSGILEAVQHLPCLERLDLTNNSIMYLDHSPRSLVSLTHL 252

  Fly   424 NLAENRLHTLD------------------DKLFNGLYV-----LSKLTLNNNLISVVEPAVFKNC 465
            :...|:|..|:                  :|:...:|:     |..|.|:..:|. :|....|:.
Mouse   253 SFEGNKLRELNFSALSLPNLTNLSASRNGNKVIQNVYLKTLPQLKSLNLSGTVIK-LENLSAKHL 316

  Fly   466 SDLKELDLSSNQLNE-------VPRALQDLAMLRT------------------------LDLGEN 499
            .:|:.:|||:.:|..       |...|.:|..|.|                        ||||:|
Mouse   317 QNLRAMDLSNWELRHGHLDMKTVCHLLGNLPKLETLVFQKNVTNAEGIKQLAKCTRLLFLDLGQN 381

  Fly   500 QIRTFDNQS-FKNLHQLTGLRLIDNQIGNITVGMFQDLPRLSVLNLAKNRIQSIERGSFDKNFEL 563
            ....:.|.| |..|..|..|.|...|:..|....:..|..|:.|:|:.|:.:|....:|.....|
Mouse   382 SDLIYLNDSEFNALPSLQKLNLNKCQLSFINNRTWSSLQNLTSLDLSHNKFKSFPDFAFSPLKHL 446

  Fly   564 EAIRLDRNFLADINGV-FATLVSLLWLNLSENHLVWFD-YAFIP-SNLKWLDIHGNYIEAL--GN 623
            |.:.|.||.:.::|.: |:.|.:|..|||:...:|..| |:|.. .||:.||:..|.|..|  |.
Mouse   447 EFLSLSRNPITELNNLAFSGLFALKELNLAACWIVTIDRYSFTQFPNLEVLDLGDNNIRTLNHGT 511

  Fly   624 YYKLQEEIRVKTLDASHNRITEIGPMSIPNTIELLFINNNLIGNVQPNAFVDKANLARVDLYANQ 688
            :..|::                         ::.|.:::|.:..::||:|....||..:||..|.
Mouse   512 FRPLKK-------------------------LQSLILSHNCLKILEPNSFSGLTNLRSLDLMYNS 551

  Fly   689 LSKLQ------LQQLRVAPVVAPKPLPEFYLGGNPFECDCTMDWLQRINNLTTR--QHP-----R 740
            ||...      |::|.:           ..||.|            :|...|||  |:|     :
Mouse   552 LSYFHEHLFSGLEKLLI-----------LKLGFN------------KITYETTRTLQYPPFIKLK 593

  Fly   741 VMDMANIE------CVMP----HARGAAVRPLSGLRPQDFLCRYESHCFALCHCCDFDACDCEMT 795
            .:...|:|      .|:|    ...|:....|.|..|..||   :.|.|                
Mouse   594 SLKQLNLEGQRHGIQVVPSNFFQGLGSLQELLLGKNPSVFL---DHHQF---------------- 639

  Fly   796 CPSNCTCYHDQIWSTNVVDCGGQQTTELPRRVPMDSSVVYLDGNNFPVLKNHAFIGRKNLRALYV 860
                     |.:.:...:|..|.:                 ||:                |:||:
Mouse   640 ---------DPLINLTKLDISGTK-----------------DGD----------------RSLYL 662

  Fly   861 NGSQVAAIQNRTFASLASLQLLHLADNKLRTLHGYEFEQLSALRELYLQNNQLTTIENATLAPLA 925
            |.|        .|.:|..|::|.|.:|.|.:|....|..|.:|:...|:.|.|..|..:.|..|.
Mouse   663 NAS--------LFQNLKRLKILRLENNNLESLVPDMFSSLQSLQVFSLRFNNLKVINQSHLKNLK 719

  Fly   926 ALELIRIDGNRLVTLPIWQMHATHFGTRLKSISLGRNQWSCRCQ-----FLQALTSYVADNALIV 985
            :|....:.||:|               :....:|....||...:     ||::.......:..::
Mouse   720 SLMFFDVYGNKL---------------QCTCDNLWFKNWSMNTEEVHIPFLRSYPCQQPGSQSLL 769

  Fly   986 QDAQDIYCMAASSGTGSAALEDSSSNSGSLEKRELDFNATGAACTDYYSGGSMLQHGIPESYIPL 1050
            .|..|..|                         ..|.......|:                    
Mouse   770 IDFDDAMC-------------------------NFDLGKVYFLCS-------------------- 789

  Fly  1051 LAAALALLFLLVVIAMVFAFRESLRI---WLFAHYGVRV----FGPRCEESEK--LYDAVLLHSA 1106
                    |.:|:..|||::..:..|   |    ||:.:    :..:..::||  ||||.:..||
Mouse   790 --------FSMVLSTMVFSWFSTKMIASLW----YGLYICRAWYLTKWHKTEKKFLYDAFVSFSA 842

  Fly  1107 KDSEFVCQHLAAQLETG-RPPLRVCLQHRDLAHDATHYQLLE-ATRVSRRVVILLTRNFLQTEWA 1169
            .|..:|.:.|...||.| :...::||..||.......::.:: |...||:.:.:::.::|.:||.
Mouse   843 TDEAWVYKELVPALEQGSQTTFKLCLHQRDFEPGIDIFENIQNAINTSRKTLCVVSNHYLHSEWC 907

  Fly  1170 RCELRRSVHDALRGRPQKLVIIEEPEVAFEAESDIELLPYLKTSAVHRIRR-----------SDR 1223
            |.|::.:...........:::|           .:|.:|..|.|:.||:|:           ...
Mouse   908 RLEVQLASMKMFYEHKDVIILI-----------FLEEIPNYKLSSYHRLRKLINKQTFITWPDSV 961

  Fly  1224 H----FWEKLRYAL 1233
            |    ||.::|.||
Mouse   962 HQQPLFWARIRNAL 975

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-7NP_523797.1 LRR_8 135..201 CDD:290566
leucine-rich repeat 136..159 CDD:275380
leucine-rich repeat 160..190 CDD:275380
LRR_8 189..259 CDD:290566 241/1119 (22%)
leucine-rich repeat 191..214 CDD:275380
leucine-rich repeat 215..248 CDD:275380
LRR_RI 247..501 CDD:238064 75/325 (23%)
LRR_8 247..308 CDD:290566 10/53 (19%)
leucine-rich repeat 249..273 CDD:275380 3/13 (23%)
leucine-rich repeat 274..297 CDD:275380 4/22 (18%)
LRR_8 297..356 CDD:290566 16/59 (27%)
leucine-rich repeat 298..321 CDD:275380 6/23 (26%)
leucine-rich repeat 322..345 CDD:275380 6/22 (27%)
LRR_8 345..406 CDD:290566 21/60 (35%)
leucine-rich repeat 346..371 CDD:275380 8/24 (33%)
leucine-rich repeat 372..395 CDD:275380 9/22 (41%)
leucine-rich repeat 396..419 CDD:275380 10/47 (21%)
LRR_8 419..478 CDD:290566 17/81 (21%)
leucine-rich repeat 420..443 CDD:275380 6/40 (15%)
leucine-rich repeat 444..467 CDD:275380 6/22 (27%)
LRR_RI 466..622 CDD:238064 54/192 (28%)
leucine-rich repeat 468..488 CDD:275380 7/26 (27%)
LRR_8 491..549 CDD:290566 21/82 (26%)
leucine-rich repeat 491..514 CDD:275380 11/47 (23%)
leucine-rich repeat 515..536 CDD:275380 5/20 (25%)
leucine-rich repeat 539..562 CDD:275380 6/22 (27%)
leucine-rich repeat 563..585 CDD:275380 8/22 (36%)
leucine-rich repeat 586..626 CDD:275380 16/43 (37%)
leucine-rich repeat 627..653 CDD:275380 1/25 (4%)
LRRCT 716..772 CDD:214507 16/72 (22%)
LRRNT 796..830 CDD:214470 3/33 (9%)
leucine-rich repeat 812..829 CDD:275380 2/16 (13%)
leucine-rich repeat 833..854 CDD:275380 2/20 (10%)
LRR_8 853..913 CDD:290566 18/59 (31%)
leucine-rich repeat 855..878 CDD:275380 7/22 (32%)
LRR_4 878..918 CDD:289563 13/39 (33%)
leucine-rich repeat 879..902 CDD:275380 8/22 (36%)
leucine-rich repeat 903..926 CDD:275380 7/22 (32%)
leucine-rich repeat 927..953 CDD:275380 4/25 (16%)
TIR 1098..1235 CDD:214587 37/153 (24%)
Tlr13NP_991389.1 LRR 1 104..125 6/20 (30%)
leucine-rich repeat 105..128 CDD:275380 6/22 (27%)
LRR_8 106..163 CDD:290566 16/56 (29%)
LRR 2 128..149 5/20 (25%)
leucine-rich repeat 129..152 CDD:275380 6/22 (27%)
LRR 3 152..174 7/24 (29%)
leucine-rich repeat 153..175 CDD:275380 8/24 (33%)
LRR 4 175..196 8/20 (40%)
leucine-rich repeat 176..199 CDD:275380 9/22 (41%)
LRR_8 183..236 CDD:290566 15/52 (29%)
LRR_RI <192..405 CDD:238064 47/213 (22%)
LRR 5 199..220 7/20 (35%)
leucine-rich repeat 200..225 CDD:275380 8/24 (33%)
LRR 6 225..246 0/20 (0%)
leucine-rich repeat 226..248 CDD:275380 1/21 (5%)
LRR 7 248..268 5/19 (26%)
leucine-rich repeat 249..271 CDD:275380 5/21 (24%)
LRR 8 271..292 2/20 (10%)
leucine-rich repeat 272..295 CDD:275380 2/22 (9%)
LRR 9 295..315 5/20 (25%)
leucine-rich repeat 296..319 CDD:275380 6/23 (26%)
LRR 10 318..338 5/19 (26%)
LRR 11 348..368 2/19 (11%)
LRR 12 372..394 8/21 (38%)
leucine-rich repeat 373..397 CDD:275380 9/23 (39%)
LRR_8 396..456 CDD:290566 17/59 (29%)
LRR 13 397..418 5/20 (25%)
leucine-rich repeat 398..421 CDD:275380 6/22 (27%)
LRR_4 420..463 CDD:289563 12/42 (29%)
LRR 14 421..442 6/20 (30%)
leucine-rich repeat 422..445 CDD:275380 6/22 (27%)
LRR 15 445..466 7/20 (35%)
leucine-rich repeat 446..469 CDD:275380 8/22 (36%)
LRR 16 469..490 8/20 (40%)
leucine-rich repeat 470..493 CDD:275380 8/22 (36%)
LRR_8 492..552 CDD:290566 19/84 (23%)
LRR 17 493..514 8/20 (40%)
leucine-rich repeat 494..517 CDD:275380 8/22 (36%)
LRR 18 517..538 5/45 (11%)
leucine-rich repeat 518..541 CDD:275380 5/22 (23%)
LRR_8 540..602 CDD:290566 19/84 (23%)
LRR 19 541..562 7/20 (35%)
leucine-rich repeat 542..565 CDD:275380 7/22 (32%)
LRR 20 565..585 8/42 (19%)
leucine-rich repeat 566..585 CDD:275380 8/41 (20%)
LRR 21 594..617 4/22 (18%)
LRR 22 620..641 7/48 (15%)
LRR 23 644..665 8/53 (15%)
LRR_8 671..731 CDD:290566 18/59 (31%)
LRR 24 672..693 7/20 (35%)
leucine-rich repeat 673..696 CDD:275380 8/22 (36%)
LRR 25 696..716 5/19 (26%)
leucine-rich repeat 697..718 CDD:275380 6/20 (30%)
TIR 834..976 CDD:214587 37/153 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4641
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 178 1.000 Inparanoid score I4007
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
54.830

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