DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-7 and Tlr11

DIOPT Version :9

Sequence 1:	NP_523797.1	Gene:	Toll-7 / 37272	FlyBaseID:	FBgn0034476	Length:	1446	Species:	Drosophila melanogaster
Sequence 2:	NP_991388.2	Gene:	Tlr11 / 239081	MGIID:	3045226	Length:	931	Species:	Mus musculus

Alignment Length:	1058	Identity:	240/1058 - (22%)
Similarity:	373/1058 - (35%)	Gaps:	323/1058 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   278 NLAYNNLSE-----LSGEALAGLASLRIVNLSNNHLETLPEGLFAGSKELREIHLQQNELYELPK 337
            :|.:.|||.     .|...|..|||...|...|..|:.:|..        .|:...|..:..||.
Mouse    46 SLLFPNLSYYIPFCTSAPGLHLLASCSNVKNLNQTLKRVPRN--------TEVLCLQGMVPTLPA 102

  Fly   338 GLFHRLEQLLVVDLSGNQLTSNHVDNTTFAGLIRLIVLNLAHNA------------------LTR 384
            ..|.|...|.::.|   ||.:..|.:.||.||.:|..|...|:|                  |:.
Mouse   103 KAFIRFHSLQLLRL---QLRTTSVTSRTFQGLDQLQYLFFDHHAPCCLSLFLSPNCFESLRSLSS 164

  Fly   385 IDYRTF-----KELYF---LQILNLRNNSIGHIED--NAF--LPLYNLHTLNLAENR--LHTLDD 435
            :.::.:     :.:|.   |:.|.|||:.:...:|  ..|  |.|....|.|:....  |.|| |
Mouse   165 LSFQGYCLTYSQSIYLPTSLRHLTLRNSCLTKFQDLQRLFPDLLLSTSSTPNIKPGAPFLETL-D 228

  Fly   436 KLFN------GLYVLSKLTLNNNLISVVEPAVFKNCSDLKELDLSSNQL-------------NEV 481
            ..:|      |:..|..|||::.::         :.:.||.|||:.:.|             .:|
Mouse   229 LSYNLQLKQAGVRDLYGLTLHSLIL---------DGTPLKALDLTDSGLLHLHFLSLVGTGIEKV 284

  Fly   482 PRALQDLAMLRTLDLGENQIRT-FDNQSFKNLHQLTGLRLIDNQIGNITVGMFQDLPRLSVLNLA 545
            |.:|...:.||.||||:|||:. .:|........|..|.|.||.:..:.......||:|..|||:
Mouse   285 PASLTGYSELRALDLGKNQIQNILENGEIPGYKALEFLSLHDNHLQTLPTRFLHTLPQLQKLNLS 349

  Fly   546 KNR---IQSIERGSFDKNFELEAIRLDRNFLADI-NGVFATLVSL--LWLNLSENHLVWFDYAFI 604
            .|:   |..:..|.|..|  |:.:.|..|.|.|: :|..:.|..|  |||:
Mouse   350 MNKLGPILELPEGLFSTN--LKVLDLSYNQLCDVPHGALSLLSQLQELWLS-------------- 398

  Fly   605 PSNLKWLDIHGNYIEALGNYYKLQEEIRVKTLDASHNRITEIGPMSIPNTIELLFINNNLIGNVQ 669
                      ||.|.:|.| ..||...:::|||.|.|:|..:.|..:.:...|..:  ||:|.
Mouse   399 ----------GNNISSLSN-ESLQGLRQLRTLDLSWNQIKVLKPGWLSHLPALTTL--NLLGT-- 448

  Fly   670 PNAFVDKANLARVDLYANQLSKLQLQQLRVAPVVAPKPLPEFYLGGNPFECDCTMDW-------- 726
                           |...:..:|||        .||.|....||..|. .|....|
Mouse   449 ---------------YLEYILGIQLQ--------GPKMLRHLQLGSYPI-LDIYPPWPPTLLSLE 489

  Fly   727 LQR----------------INNLTTRQHPRVMDMANIECVMPHARGAAVRPLSGLRPQDFLCRYE 775
            :|.                :.|||......::...||....|..|...:|..|.:.....|.|:.
Mouse   490 IQAESCIQFMIHSGQPFLFLENLTLETSILLLKPDNITIHFPSLRRLTLRGYSFIFSTSQLQRFF 554

  Fly   776 SHCFALCHCCDFDACDCEMTCPSNCTCYHDQIWSTN--VVDCGGQQTTELPRRVPMDSSVVYLDG 838
            .....|..                    |..||..|  .||                   :||
Mouse   555 PQQLPLLE--------------------HFFIWCENSYAVD-------------------LYL-- 578

  Fly   839 NNFPVLKNHAFIGRKNLRAL---YVN---GSQVAAIQNRTFASLASLQLLHLADNKLRTLHGYEF 897
                       .|...||.|   |:|   .|....:: .....:..||:|.|:...||.|....|
Mouse   579 -----------FGMPRLRVLELGYLNFFYESSTMKLE-MLLKEVPQLQVLALSHLNLRNLSVSSF 631

  Fly   898 EQLSALRELYLQNNQLTTIENATLAPLAALELIRIDGNRLVTLPIWQMHATHFGTRLKSISLGRN 962
            :.|..|: |.|.|::            .|||:   :.|....:|  ||.        :.:.....
Mouse   632 KSLQDLK-LLLFNSE------------RALEM---NSNLQEFIP--QMP--------QYVYFSDV 670

  Fly   963 QWSCRCQ--FLQALTSYVADNALIVQDAQDIYCMAASSGTGSAALEDSSSNSGSLEKRELDFNAT 1025
            .::|:|:  :|::..:. |.|..:....:.| |:|.:|......|              ..|.||
Mouse   671 TFTCQCEASWLESWATR-APNTFVYGLEKSI-CIANASDYSKTLL--------------FSFLAT 719

  Fly  1026 GAAC---TDYYSGGSMLQHGIPESYIPLLAAALALLFLLVVIAMVFAFRESLRIWLFAHYGVRVF 1087
            .  |   |:::        |...|:|        ||.||:::.::     |...|.:.|:...:|
Mouse   720 N--CPHGTEFW--------GFLTSFI--------LLLLLIILPLI-----SCPKWSWLHHLWTLF 761

  Fly  1088 --------GPRCEESEKLYDAVLLHSAKDSEFVCQHLAAQLETGRPP---LRVCLQHRD--LAHD 1139
                    |.|. ..:..||..:.:..:|..:|.:.|...||...|.   ||:||..||  :.:|
Mouse   762 HTCWWKLCGHRL-RGQFNYDVFISYCEEDQAWVLEELVPVLEKAPPEGEGLRLCLPARDFGIGND 825

  Fly  1140 ATHYQLLEATRVSRRVVILLTRNFLQTEWARCELRRSVHD--ALRGRPQKLVIIEEPEVAFEAES 1202
            ... .::.:...||..:.:||...|.:.|...|||.:.:.  |..|....|::..||
Mouse   826 RME-SMIASMGKSRATLCVLTGQALASPWCNLELRLATYHLVARPGTTHLLLLFLEP-------- 881

  Fly  1203 DIELLPYLKTSAVHRIRR 1220
                |...:..:.||:.|
Mouse   882 ----LDRQRLHSYHRLSR 895

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-7	NP_523797.1	LRR_8	135..201	CDD:290566
		leucine-rich repeat	136..159	CDD:275380
		leucine-rich repeat	160..190	CDD:275380
		LRR_8	189..259	CDD:290566
		leucine-rich repeat	191..214	CDD:275380
		leucine-rich repeat	215..248	CDD:275380
		LRR_RI	247..501	CDD:238064	71/278 (26%)
		LRR_8	247..308	CDD:290566	11/34 (32%)
		leucine-rich repeat	249..273	CDD:275380
		leucine-rich repeat	274..297	CDD:275380	7/23 (30%)
		LRR_8	297..356	CDD:290566	13/58 (22%)
		leucine-rich repeat	298..321	CDD:275380	4/22 (18%)
		leucine-rich repeat	322..345	CDD:275380	6/22 (27%)
		LRR_8	345..406	CDD:290566	20/86 (23%)
		leucine-rich repeat	346..371	CDD:275380	9/24 (38%)
		leucine-rich repeat	372..395	CDD:275380	5/45 (11%)
		leucine-rich repeat	396..419	CDD:275380	9/26 (35%)
		LRR_8	419..478	CDD:290566	17/66 (26%)
		leucine-rich repeat	420..443	CDD:275380	8/30 (27%)
		leucine-rich repeat	444..467	CDD:275380	4/22 (18%)
		LRR_RI	466..622	CDD:238064	49/175 (28%)
		leucine-rich repeat	468..488	CDD:275380	9/32 (28%)
		LRR_8	491..549	CDD:290566	22/61 (36%)
		leucine-rich repeat	491..514	CDD:275380	10/23 (43%)
		leucine-rich repeat	515..536	CDD:275380	5/20 (25%)
		leucine-rich repeat	539..562	CDD:275380	9/25 (36%)
		leucine-rich repeat	563..585	CDD:275380	7/22 (32%)
		leucine-rich repeat	586..626	CDD:275380	9/41 (22%)
		leucine-rich repeat	627..653	CDD:275380	9/25 (36%)
		LRRCT	716..772	CDD:214507	13/79 (16%)
		LRRNT	796..830	CDD:214470	6/35 (17%)
		leucine-rich repeat	812..829	CDD:275380	2/16 (13%)
		leucine-rich repeat	833..854	CDD:275380	3/20 (15%)
		LRR_8	853..913	CDD:290566	19/65 (29%)
		leucine-rich repeat	855..878	CDD:275380	6/28 (21%)
		LRR_4	878..918	CDD:289563	13/39 (33%)
		leucine-rich repeat	879..902	CDD:275380	9/22 (41%)
		leucine-rich repeat	903..926	CDD:275380	4/22 (18%)
		leucine-rich repeat	927..953	CDD:275380	6/25 (24%)
		TIR	1098..1235	CDD:214587	33/130 (25%)
Tlr11	NP_991388.2	LRR_RI	<184..427	CDD:238064	79/279 (28%)
		leucine-rich repeat	224..246	CDD:275380	7/22 (32%)
		leucine-rich repeat	248..270	CDD:275380	7/30 (23%)
		leucine-rich repeat	271..293	CDD:275380	3/21 (14%)
		leucine-rich repeat	294..318	CDD:275380	10/23 (43%)
		LRR_8	319..378	CDD:290566	19/60 (32%)
		leucine-rich repeat	319..342	CDD:275380	6/22 (27%)
		leucine-rich repeat	343..367	CDD:275380	8/23 (35%)
		LRR_8	366..426	CDD:290566	24/86 (28%)
		leucine-rich repeat	368..391	CDD:275380	7/22 (32%)
		leucine-rich repeat	392..415	CDD:275380	11/47 (23%)
		LRR_8	414..471	CDD:290566	19/83 (23%)
		leucine-rich repeat	416..437	CDD:275380	7/20 (35%)
		leucine-rich repeat	440..463	CDD:275380	9/49 (18%)
		TIR_2	781..>861	CDD:290400	22/80 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010