DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Toll-7 and Nyx

DIOPT Version :9

Sequence 1:	NP_523797.1	Gene:	Toll-7 / 37272	FlyBaseID:	FBgn0034476	Length:	1446	Species:	Drosophila melanogaster
Sequence 2:	NP_775591.1	Gene:	Nyx / 236690	MGIID:	2448607	Length:	476	Species:	Mus musculus

Alignment Length:	477	Identity:	108/477 - (22%)
Similarity:	159/477 - (33%)	Gaps:	162/477 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   301 VNLSNNHLETLPEGLFAGSKELREIHLQQNELYELPKGLFHRLEQLLVVDLSGNQLTSNHVDNTT 365
            ::|..|.|..|.|..|.....||.:.|:.|.|..:..|                          .
Mouse    62 IDLDRNGLRILGERAFGTLPSLRRLSLRHNNLSFITPG--------------------------A 100

  Fly   366 FAGLIRLIVLNLAHNALTRIDYRTFKELYFLQILNLRNNSIGHIEDNAFLPLYNLHTLNLAENRL 430
            |.||.||..|.||||.          ||.:|.:             ..|..|..|..|:||..||
Mouse   101 FKGLPRLAELRLAHNG----------ELRYLHV-------------RTFAALGRLRRLDLAACRL 142

  Fly   431 HTLDDKLFNGLYVLSKLTLNNNLISVVEPAVFKNCSDLKELDLSSNQLNEVPR-ALQDLAMLRTL 494
            .::.::|...|..|.:||..:||...| |...:..::|.......:::..|.. :|..:..||:|
Mouse   143 FSVPERLLAELPALRELTAFDNLFRRV-PGALRGLANLTHAHFERSRIEAVASGSLLGMRRLRSL 206

  Fly   495 DLGENQIRTFDNQSFKNLHQLTGLRLIDNQIGNITVGMFQDLPRLSVLNLAKNRIQSIERGSFDK 559
            .|..|::|.....:|.:...|..|.|.||.:..:....|:.|.||..|||..|.:.|:.|..|..
Mouse   207 SLQANRVRAVHAGAFGDCGALEDLLLNDNLLATLPAAAFRGLRRLRTLNLGGNALGSVARAWFSD 271

  Fly   560 NFELEAIRLDRNFLADI-NGVFATLVSLLWLNLSENHLVWFDYAFIPSNLKWLDIHGNYIEALGN 623
            ..|||.:.||||.:..: .|.|..|..||.|:|:.|.|....:|..
Mouse   272 LAELELLYLDRNSITFVEEGAFQNLSGLLALHLNGNRLTVLSWAAF------------------- 317

  Fly   624 YYKLQEEIRVKTLDASHNRITEIGPMSIPNTIELLFINNNLIGNVQPNAFVDKANLARVDLYANQ 688
                                                         ||..|:.:..|.|
Mouse   318 ---------------------------------------------QPGFFLGRLFLFR------- 330

  Fly   689 LSKLQLQQLRVAPVVAPKPLPEFYLGGNPFECDCTMDWLQRINNLTTRQHPRVMDMANIECVMPH 753
                                       ||:.|||.::||:.....:.|       :|::.|..|.
Mouse   331 ---------------------------NPWRCDCQLEWLRDWMEGSGR-------VADVACASPG 361

  Fly   754 ARGAAVRPLSGL---RPQDFLC 772
            :  .|.:.||.:   |..|.||
Mouse   362 S--VAGQDLSQVVFERSSDGLC 381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-7	NP_523797.1	LRR_8	135..201	CDD:290566
		leucine-rich repeat	136..159	CDD:275380
		leucine-rich repeat	160..190	CDD:275380
		LRR_8	189..259	CDD:290566
		leucine-rich repeat	191..214	CDD:275380
		leucine-rich repeat	215..248	CDD:275380
		LRR_RI	247..501	CDD:238064	50/200 (25%)
		LRR_8	247..308	CDD:290566	2/6 (33%)
		leucine-rich repeat	249..273	CDD:275380
		leucine-rich repeat	274..297	CDD:275380
		LRR_8	297..356	CDD:290566	12/54 (22%)
		leucine-rich repeat	298..321	CDD:275380	6/19 (32%)
		leucine-rich repeat	322..345	CDD:275380	6/22 (27%)
		LRR_8	345..406	CDD:290566	13/60 (22%)
		leucine-rich repeat	346..371	CDD:275380	3/24 (13%)
		leucine-rich repeat	372..395	CDD:275380	8/22 (36%)
		leucine-rich repeat	396..419	CDD:275380	3/22 (14%)
		LRR_8	419..478	CDD:290566	16/58 (28%)
		leucine-rich repeat	420..443	CDD:275380	8/22 (36%)
		leucine-rich repeat	444..467	CDD:275380	7/22 (32%)
		LRR_RI	466..622	CDD:238064	43/157 (27%)
		leucine-rich repeat	468..488	CDD:275380	3/20 (15%)
		LRR_8	491..549	CDD:290566	20/57 (35%)
		leucine-rich repeat	491..514	CDD:275380	7/22 (32%)
		leucine-rich repeat	515..536	CDD:275380	6/20 (30%)
		leucine-rich repeat	539..562	CDD:275380	8/22 (36%)
		leucine-rich repeat	563..585	CDD:275380	9/22 (41%)
		leucine-rich repeat	586..626	CDD:275380	7/39 (18%)
		leucine-rich repeat	627..653	CDD:275380	0/25 (0%)
		LRRCT	716..772	CDD:214507	16/58 (28%)
		LRRNT	796..830	CDD:214470
		leucine-rich repeat	812..829	CDD:275380
		leucine-rich repeat	833..854	CDD:275380
		LRR_8	853..913	CDD:290566
		leucine-rich repeat	855..878	CDD:275380
		LRR_4	878..918	CDD:289563
		leucine-rich repeat	879..902	CDD:275380
		leucine-rich repeat	903..926	CDD:275380
		leucine-rich repeat	927..953	CDD:275380
		TIR	1098..1235	CDD:214587
Nyx	NP_775591.1	LRRNT	25..56	CDD:214470
		LRR 1	58..79		6/16 (38%)
		LRR_8	61..115	CDD:338972	20/78 (26%)
		leucine-rich repeat	63..82	CDD:275380	6/18 (33%)
		LRR_RI	<68..312	CDD:393385	82/293 (28%)
		LRR 2	82..103		7/46 (15%)
		leucine-rich repeat	83..106	CDD:275380	9/48 (19%)
		LRR 3	106..128		11/44 (25%)
		leucine-rich repeat	107..131	CDD:275380	11/46 (24%)
		LRR 4	131..154		7/22 (32%)
		leucine-rich repeat	132..155	CDD:275380	8/22 (36%)
		LRR 5	155..177		7/22 (32%)
		leucine-rich repeat	156..178	CDD:275380	7/22 (32%)
		LRR 6	178..199		3/20 (15%)
		leucine-rich repeat	179..202	CDD:275380	3/22 (14%)
		LRR 7	202..223		7/20 (35%)
		leucine-rich repeat	203..226	CDD:275380	7/22 (32%)
		LRR 8	226..247		6/20 (30%)
		leucine-rich repeat	227..250	CDD:275380	7/22 (32%)
		LRR_8	250..309	CDD:338972	24/58 (41%)
		LRR 9	250..271		9/20 (45%)
		leucine-rich repeat	251..274	CDD:275380	8/22 (36%)
		LRR 10	274..295		9/20 (45%)
		leucine-rich repeat	275..296	CDD:275380	8/20 (40%)
		LRR 11	298..319		7/84 (8%)
		leucine-rich repeat	299..322	CDD:275378	9/86 (10%)
		leucine-rich repeat	323..335	CDD:275378	4/45 (9%)
		LRRCT	331..>366	CDD:214507	12/43 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100