DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Toll-7 and Lrrc3b

DIOPT Version :9

Sequence 1:	NP_523797.1	Gene:	Toll-7 / 37272	FlyBaseID:	FBgn0034476	Length:	1446	Species:	Drosophila melanogaster
Sequence 2:	NP_666164.1	Gene:	Lrrc3b / 218763	MGIID:	2384996	Length:	259	Species:	Mus musculus

Alignment Length:	230	Identity:	52/230 - (22%)
Similarity:	79/230 - (34%)	Gaps:	70/230 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   770 FLCRYESHC-----FALCHCCDFDACDCEMTCPSNCTCYHDQIWSTNVVDCGGQQTTELPRRVPM 829
            :|.|..|.|     |.|...|...|    ..||..|.|  ......||. |......|:||.:|.
Mouse     7 WLSRSLSMCLLLQSFVLMILCFHSA----SMCPKGCLC--SSSGGLNVT-CSNANLKEIPRDLPP 64

  Fly   830 DSSVVYLDGNNFPVLKNHAFIGRKNLRALYVNGSQVAAIQNRTFASLA-SLQLLHLADNKLRTLH 893
            ::.::|||.|....:.|..|.....||.|.::.:.:..|....|..:| :||.|.|:||:::::|
Mouse    65 ETVLLYLDSNQITSIPNEIFKDLHQLRVLNLSKNGIEFIDEHAFKGVAETLQTLDLSDNRIQSVH 129

  Fly   894 GYEFEQLSALRELYLQNNQLTTIENATLAPLAALELIRIDGNRLVTLPIWQMHATHFGTRLKSIS 958
            ...|..|.|               .|.:|
Mouse   130 KNAFNNLKA---------------RARIA------------------------------------ 143

  Fly   959 LGRNQWSCRCQFLQALTSYVADNALIVQDAQDIYC 993
              .|.|.|.|...|.|.|..:::    :.|.::.|
Mouse   144 --NNPWHCDCTLQQVLRSMASNH----ETAHNVIC 172

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-7	NP_523797.1	LRR_8	135..201	CDD:290566
		leucine-rich repeat	136..159	CDD:275380
		leucine-rich repeat	160..190	CDD:275380
		LRR_8	189..259	CDD:290566
		leucine-rich repeat	191..214	CDD:275380
		leucine-rich repeat	215..248	CDD:275380
		LRR_RI	247..501	CDD:238064
		LRR_8	247..308	CDD:290566
		leucine-rich repeat	249..273	CDD:275380
		leucine-rich repeat	274..297	CDD:275380
		LRR_8	297..356	CDD:290566
		leucine-rich repeat	298..321	CDD:275380
		leucine-rich repeat	322..345	CDD:275380
		LRR_8	345..406	CDD:290566
		leucine-rich repeat	346..371	CDD:275380
		leucine-rich repeat	372..395	CDD:275380
		leucine-rich repeat	396..419	CDD:275380
		LRR_8	419..478	CDD:290566
		leucine-rich repeat	420..443	CDD:275380
		leucine-rich repeat	444..467	CDD:275380
		LRR_RI	466..622	CDD:238064
		leucine-rich repeat	468..488	CDD:275380
		LRR_8	491..549	CDD:290566
		leucine-rich repeat	491..514	CDD:275380
		leucine-rich repeat	515..536	CDD:275380
		leucine-rich repeat	539..562	CDD:275380
		leucine-rich repeat	563..585	CDD:275380
		leucine-rich repeat	586..626	CDD:275380
		leucine-rich repeat	627..653	CDD:275380
		LRRCT	716..772	CDD:214507	0/1 (0%)
		LRRNT	796..830	CDD:214470	11/33 (33%)
		leucine-rich repeat	812..829	CDD:275380	5/16 (31%)
		leucine-rich repeat	833..854	CDD:275380	6/20 (30%)
		LRR_8	853..913	CDD:290566	16/60 (27%)
		leucine-rich repeat	855..878	CDD:275380	6/23 (26%)
		LRR_4	878..918	CDD:289563	10/39 (26%)
		leucine-rich repeat	879..902	CDD:275380	9/22 (41%)
		leucine-rich repeat	903..926	CDD:275380	2/22 (9%)
		leucine-rich repeat	927..953	CDD:275380	0/25 (0%)
		TIR	1098..1235	CDD:214587
Lrrc3b	NP_666164.1	LRRNT	33..68	CDD:214470	11/37 (30%)
		LRR 1	65..86		6/20 (30%)
		leucine-rich repeat	66..89	CDD:275378	6/22 (27%)
		LRR_8	69..125	CDD:404697	18/55 (33%)
		LRR 2	89..110		5/20 (25%)
		leucine-rich repeat	90..113	CDD:275378	5/22 (23%)
		LRR 3	114..135		8/20 (40%)
		leucine-rich repeat	115..138	CDD:275378	9/22 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010