DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Toll-7 and Chadl

DIOPT Version :9

Sequence 1:NP_523797.1 Gene:Toll-7 / 37272 FlyBaseID:FBgn0034476 Length:1446 Species:Drosophila melanogaster
Sequence 2:XP_006520805.1 Gene:Chadl / 214685 MGIID:3036284 Length:759 Species:Mus musculus


Alignment Length:693 Identity:177/693 - (25%)
Similarity:264/693 - (38%) Gaps:183/693 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   478 LNEVPRALQDLAMLRTLDLGENQIRTFDNQSFKNLHQLTGLRLIDNQIGNITVGMFQDLPRLSVL 542
            |.|||..:.:|.  :.|||..|.::.....:|::|..||.|.|.:.|:..:..|.|:.|.||.:|
Mouse    63 LTEVPNTIPELT--QRLDLQGNILKVLPAAAFQDLPHLTHLDLRNCQVEMVAEGAFRGLGRLLLL 125

  Fly   543 NLAKNRIQSIERGSFDKNFELEAIRLDRNFLADIN-GVFATLVSLLWLNLSENHLV--------- 597
            |||.||:.::.:.:.|....|..:.|:.|.|.::. |.|..|.||..|||:.|.||         
Mouse   126 NLASNRLSTLPQEALDGLGSLRRLELEGNMLEELRPGTFGALGSLTTLNLAHNALVYLPAMAFQG 190

  Fly   598 -----WFD-------------YAFIPSNLKWLDIHGNYIEALGNYYKLQEEIRVKTLDASHNRIT 644
                 |..             .|.:|: |:.|.:|.|.::||.. ..|.:...:..|:..||.:|
Mouse   191 LLRTRWLQLSHNALSVLAPEALAGLPA-LRRLSLHHNELQALPG-AALSQARSLARLELGHNPLT 253

  Fly   645 EIGP---MSIPNTIELLFINNNL--IGNVQPNAFVDKANLARVDLYANQLSKLQLQQLRVAPVVA 704
            ..|.   :::|...||...:.:|  :|   |.||.....|..:||..|||:.|       .|:..
Mouse   254 YTGEEDGLALPGLRELALDHGSLQALG---PRAFAHCPRLHTLDLRGNQLTTL-------PPLQV 308

  Fly   705 PKPLPEFYLGGNPFECDC----TMDWL--QRINNLTTRQHPRVMDMANIECVMPHARGAAVRPLS 763
            |..|....|.|||..|.|    .::||  .|:.:....:.||            ..||.|   |.
Mouse   309 PGQLRRLRLQGNPLWCACHARPLLEWLVRARVRSDGACRGPR------------RLRGEA---LD 358

  Fly   764 GLRPQDFLCRYESHCFALCHCCDFDACDCE---------------------MTCPSNCTCYHDQI 807
            .|||.|..|..::      ...|.|..:.|                     ..||..|.|..:..
Mouse   359 TLRPSDLRCPGDA------AAGDGDGDEDEDRPAGPRAPPLRSPHGEAAWATPCPPACACVAETR 417

  Fly   808 WSTNVVDCGGQQTTELPRRVPMDSSVVYLDGNNFPVLKNHAFIGRKNL----------------- 855
            .||    |.|:....:||..|.|:.::.|..|:||.:...||.|.::|                 
Mouse   418 HST----CDGRGLQAVPRGFPNDTQLLDLRRNHFPSVPRAAFPGLRHLVSLHLQHCGVAELEPGA 478

  Fly   856 -----RALY-------VNGSQVAAIQ------------NR-------TFASLASLQLLHLADNKL 889
                 |.||       ::|...||::            ||       ...:|.:|..|||.||.:
Mouse   479 LAGLDRLLYLYLSHNQLSGLSAAALEGAPNLGYLYLEHNRFLRIPGTALRALPTLVSLHLQDNAV 543

  Fly   890 RTLHGYEFEQLSALRELYLQNNQLTTIENATLAPLAALELIRIDGNRLVTLPIWQMHATHFGTRL 954
            ..|...:.....|||.|||..|.:|.:....|.|...||.:.:|.|||..:|...:...   ..|
Mouse   544 DRLAPGDLAGARALRCLYLSGNHITQVSPGALGPARELEKLHLDRNRLREVPTGALEGL---PAL 605

  Fly   955 KSISLGRNQWSCRCQFLQALTSYVADNAL--IVQDAQDIYCMAASSGTGSAALEDSSSNSGSLEK 1017
            |.:.|..|.       |:||    .|.|.  :.:..|.::       ..|:.||..|..:     
Mouse   606 KELQLSGNP-------LRAL----PDGAFQPVGRSLQQLF-------LNSSDLEQISPRA----- 647

  Fly  1018 RELDFNATGAACTDYYSGGSMLQHGIPESYIPLLAAALALLFL 1060
                |:..|......|...:.|| .:|   .||..:.|.|:.|
Mouse   648 ----FSGLGKGLRSLYLHKNQLQ-SLP---APLGLSGLELVDL 682

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-7NP_523797.1 LRR_8 135..201 CDD:290566
leucine-rich repeat 136..159 CDD:275380
leucine-rich repeat 160..190 CDD:275380
LRR_8 189..259 CDD:290566
leucine-rich repeat 191..214 CDD:275380
leucine-rich repeat 215..248 CDD:275380
LRR_RI 247..501 CDD:238064 9/22 (41%)
LRR_8 247..308 CDD:290566
leucine-rich repeat 249..273 CDD:275380
leucine-rich repeat 274..297 CDD:275380
LRR_8 297..356 CDD:290566
leucine-rich repeat 298..321 CDD:275380
leucine-rich repeat 322..345 CDD:275380
LRR_8 345..406 CDD:290566
leucine-rich repeat 346..371 CDD:275380
leucine-rich repeat 372..395 CDD:275380
leucine-rich repeat 396..419 CDD:275380
LRR_8 419..478 CDD:290566 177/693 (26%)
leucine-rich repeat 420..443 CDD:275380
leucine-rich repeat 444..467 CDD:275380
LRR_RI 466..622 CDD:238064 51/171 (30%)
leucine-rich repeat 468..488 CDD:275380 4/9 (44%)
LRR_8 491..549 CDD:290566 21/57 (37%)
leucine-rich repeat 491..514 CDD:275380 6/22 (27%)
leucine-rich repeat 515..536 CDD:275380 7/20 (35%)
leucine-rich repeat 539..562 CDD:275380 8/22 (36%)
leucine-rich repeat 563..585 CDD:275380 7/22 (32%)
leucine-rich repeat 586..626 CDD:275380 16/66 (24%)
leucine-rich repeat 627..653 CDD:275380 6/28 (21%)
LRRCT 716..772 CDD:214507 17/61 (28%)
LRRNT 796..830 CDD:214470 11/33 (33%)
leucine-rich repeat 812..829 CDD:275380 4/16 (25%)
leucine-rich repeat 833..854 CDD:275380 7/20 (35%)
LRR_8 853..913 CDD:290566 24/107 (22%)
leucine-rich repeat 855..878 CDD:275380 10/70 (14%)
LRR_4 878..918 CDD:289563 15/39 (38%)
leucine-rich repeat 879..902 CDD:275380 7/22 (32%)
leucine-rich repeat 903..926 CDD:275380 9/22 (41%)
leucine-rich repeat 927..953 CDD:275380 7/25 (28%)
TIR 1098..1235 CDD:214587
ChadlXP_006520805.1 PRK15370 <32..>322 CDD:185268 79/272 (29%)
leucine-rich repeat 54..72 CDD:275380 4/8 (50%)
leucine-rich repeat 74..97 CDD:275380 6/24 (25%)
leucine-rich repeat 98..121 CDD:275380 8/22 (36%)
leucine-rich repeat 122..145 CDD:275380 8/22 (36%)
leucine-rich repeat 146..169 CDD:275380 7/22 (32%)
LRR_8 169..228 CDD:338972 15/59 (25%)
leucine-rich repeat 170..193 CDD:275380 7/22 (32%)
leucine-rich repeat 194..217 CDD:275380 2/22 (9%)
leucine-rich repeat 218..241 CDD:275380 7/23 (30%)
leucine-rich repeat 242..265 CDD:275380 5/22 (23%)
leucine-rich repeat 266..289 CDD:275380 7/25 (28%)
leucine-rich repeat 312..351 CDD:275380 12/50 (24%)
LRRNT 405..439 CDD:214470 12/37 (32%)
leucine-rich repeat 437..460 CDD:275380 7/22 (32%)
LRR_8 460..519 CDD:338972 8/58 (14%)
leucine-rich repeat 461..484 CDD:275380 1/22 (5%)
leucine-rich repeat 485..508 CDD:275380 5/22 (23%)
LRR <507..>687 CDD:227223 52/210 (25%)
leucine-rich repeat 509..532 CDD:275380 3/22 (14%)
leucine-rich repeat 533..556 CDD:275380 7/22 (32%)
leucine-rich repeat 557..580 CDD:275380 9/22 (41%)
leucine-rich repeat 581..604 CDD:275380 7/25 (28%)
leucine-rich repeat 605..629 CDD:275380 9/34 (26%)
leucine-rich repeat 630..653 CDD:275380 6/38 (16%)
leucine-rich repeat 655..677 CDD:275380 6/25 (24%)
LRRCT 685..733 CDD:214507
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24373
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
33.010

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