back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-7 and Slit1

DIOPT Version :9

Sequence 1:	NP_523797.1	Gene:	Toll-7 / 37272	FlyBaseID:	FBgn0034476	Length:	1446	Species:	Drosophila melanogaster
Sequence 2:	NP_056563.2	Gene:	Slit1 / 20562	MGIID:	1315203	Length:	1531	Species:	Mus musculus

Alignment Length:	988	Identity:	220/988 - (22%)
Similarity:	351/988 - (35%)	Gaps:	314/988 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   272 RRLQHLNLAYNNLSELSGEALAGLASLRIVNLSNNHLETLPEGLFAGSKELREIHLQQNELYELP 336
            |..:.|.|..||::.:.....|||..||::.|..|.:..:..|.|...|||..:.|.:|:|..||
Mouse    61 RNTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLQVLP 125

  Fly   337 KGLFHRLEQLLVVDLSGNQLTSNHVDNTTFAGLIRLIVLNLAHNALTRIDYRTFKELYFLQILNL 401
            :.||...:.|..:|||.|.|.:  |....|.|...|..|.|..|.::.|:...|:.|..|::|.|
Mouse   126 ELLFQNNQALSRLDLSENFLQA--VPRKAFRGATDLKNLQLDKNRISCIEEGAFRALRGLEVLTL 188

  Fly   402 RNNSIGHIEDNAFLPLYNLHTLNLAENRL----------HTLDDKLFNGLY-------------- 442
            .||:|..|..::|..:..|.|..|..|.|          ..|..:...||:
Mouse   189 NNNNITTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQWLRQRPTIGLFTQCSGPASLRGLNV 253

  Fly   443 --------------------------------------------------------VLSKLTLNN 451
                                                                    .::::.|..
Mouse   254 AEVQKGEFSCSGQGEAAGAPACTLSSGSCPAMCSCSSGIVDCRGKGLTAIPANLPETMTEIRLEL 318

  Fly   452 NLISVVEPAVFKNCSDLKELDLSSNQLNEV-PRALQDLAMLRTLDLGENQIRTFDNQSFKNLHQL 515
            |.|..:.|..|.....|:.:|||:||:.|: |.|.|.|..|.:|.|..|:|.......|..|:.|
Mouse   319 NGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTL 383

  Fly   516 TGLRLIDNQIGNITVGMFQDLPRLSVLNLAKNRIQSIERGSFDKNFELEAIRLDRN-FLADINGV 579
            ..|.|..|:|..|....||||..||:|:|..|:|||:.:|:|.....::.:.|.:| |:.|.|
Mouse   384 QLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPFICDCN-- 446

  Fly   580 FATLVSLLWL-------------------------------------NLSENHLV--WFDYAF-- 603
                  |.||                                     :..|.:.:  ..||..
Mouse   447 ------LKWLADFLRTNPIETTGARCASPRRLANKRIGQIKSKKFRCSAKEQYFIPGTEDYHLNS 505

  Fly   604 --------------------------------IPSNLKWLDIHGNYI---EALGNYYKLQEEIRV 633
                                            ||.:...|.::.|.|   ||.|.:.||.   .:
Mouse   506 ECTSDVACPHKCRCEASVVECSSLKLSKIPERIPQSTTELRLNNNEISILEATGLFKKLS---HL 567

  Fly   634 KTLDASHNRITEI------GPMSI------PNTIE--------------LLFINNNLIGNVQPNA 672
            |.::.|:|:::||      |..|:      .|.:|              .|.:.||.|..:..::
Mouse   568 KKINLSNNKVSEIEDGTFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISCIHNDS 632

  Fly   673 FVDKANLARVDLYANQLSKLQ------LQQLRVAPVVAPKPLPEFYLGGNPFECDCTM----DWL 727
            |....|:..:.||.|.::.:.      ||.|....::|           |||.|:|.:    |||
Mouse   633 FTGLRNVRLLSLYDNHITTISPGAFDTLQALSTLNLLA-----------NPFNCNCHLSWLGDWL 686

  Fly   728 QRINNLTTRQHPRVMDMANIECVMPHARGAAVR--PLSGLRPQDFLC---RYESHCFALCHCCDF 787
            ::          |.:...|..|..|.    .:|  ||..:...||.|   :.|..|..
Mouse   687 RK----------RKIVTGNPRCQNPD----FLRQIPLQDVAFPDFRCEEGQEEVGCLP------- 730

  Fly   788 DACDCEMTCPSNCTCYHDQIWSTNVVDCGGQQTTELPRRVPMDSSVVYLDGNNFPVLKNH--AFI 850
                 ...||..|.|.      ..||.|..:....||:.:|.:.:.:|||||.|.::...  .|
Mouse   731 -----RPQCPQECACL------DTVVRCSNKHLQALPKGIPKNVTELYLDGNQFTLVPGQLSTF- 783

  Fly   851 GRKNLRALYVNGSQVAAIQNRTFASLASLQLLHLADNKLRTLHGYEFEQLSALRELYLQNNQLTT 915
              |.|:.:.::.::::::.|.:|.:::.|..|.|:.|.|:.:....|:.|.:||.|.|..|.::|
Mouse   784 --KYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDVST 846

  Fly   916 IENATLAPLAALELIRIDGNRLVTLPIWQMHATHFGTRLKSISLGRNQWSCRCQFLQALTSYV-- 978
            ::....|.:                           |.|..:::|.|...|.|: |:.|:|:|
Mouse   847 LQEGIFADV---------------------------TSLSHLAIGANPLYCDCR-LRWLSSWVKT 883

  Fly   979 ----------------ADNALIVQDAQDIYCMAASSGTGSA----ALEDSSSNSGSLEKRELD-F 1022
                            ....|:...|:...|....|....|    .|.....|.|:.....|: :
Mouse   884 GYKEPGIARCAGPPEMEGKLLLTTPAKKFECQGPPSLAVQAKCDPCLSSPCQNQGTCHNDPLEVY 948

  Fly  1023 NATGAACTDYYSG 1035
            ..|   |...|.|
Mouse   949 RCT---CPSGYKG 958

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.