DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Toll-7 and tol-1

DIOPT Version :9

Sequence 1:NP_523797.1 Gene:Toll-7 / 37272 FlyBaseID:FBgn0034476 Length:1446 Species:Drosophila melanogaster
Sequence 2:NP_001020983.1 Gene:tol-1 / 171635 WormBaseID:WBGene00006593 Length:1221 Species:Caenorhabditis elegans


Alignment Length:1251 Identity:323/1251 - (25%)
Similarity:548/1251 - (43%) Gaps:169/1251 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    66 NPSQPSGPANQCSWSYNGTSSVHCALRLIERQPGLDLQGADGSSQLTIQC-SELYLFESTLPVAV 129
            :|.||:.....|.:|...|:....|....::...:        ..|.|.| :..:.|    |.|.
 Worm    37 DPVQPTSKLLLCDYSSKNTTITPIASSNYDQVANI--------RSLFISCDNNNFQF----PDAY 89

  Fly   130 FARLQTLEALRLDSCKLLQLPNNAFEGLATLKSLRLSTHNSEWGPTRTLELFPDSLGGLKQLTDL 194
            |..|..|..||:..|:........||.||.|:.|.|...::   .:.:.|:..|.|..|.:|...
 Worm    90 FKSLTALHHLRIVGCETTHFSVKLFEDLAALRRLELDQIST---ASTSFEMTEDVLMPLARLEKF 151

  Fly   195 DLGDNNLRQLPSGFLCPVGNLQVLNLTRNRIRTAEQMGFADMNCGAGSGSAGSELQVLDASHNEL 259
            .|..:...:||...||.:.:|||||::.|.:.:..:    :.:|.|      .:|.::|.|.|.|
 Worm   152 SLTRSRNIELPQRLLCSLPHLQVLNISSNELPSLRR----EESCVA------QQLLIVDLSRNRL 206

  Fly   260 RSISESW-GISRLRRLQHLNLAYNNLSE------------LSGEA--LAGLASLR----IVNLSN 305
            .:|.:.. ||..:|:   :::|||:::|            |..||  :..|.||.    .|||:.
 Worm   207 TNIEQFLRGIPAIRQ---ISVAYNSIAELDLSLATPFLQQLDAEANRIVDLTSLPGTVVHVNLAG 268

  Fly   306 NHLETLPEGLFAGSKELREIHLQQNELYELPKGLFHRLEQLLVVDLSGNQLTSNHVDNTTFAGLI 370
            |.|:.:|:.: |....|..:::.:||:......:|...| |.::|.|.|:|.|..|:      .:
 Worm   269 NALKRVPDAV-AELASLVALNVSRNEIEAGNSSVFSSPE-LEMLDASYNKLDSLPVE------WL 325

  Fly   371 RLIVLNLAHNALTRIDYRTFKELYFLQILNLRNNSIGHIEDNAFLPLYNLHTLNLAENRLHTLDD 435
            :.....:||                   |:|.:|||..:.........||.||:|:.|:|....|
 Worm   326 QKCEKRIAH-------------------LHLEHNSIEQLTGGVLANATNLQTLDLSSNQLRVFRD 371

  Fly   436 KLFNGLYVLSKLTLNNNLISVVEPAVFKNCSDLKELDLSSNQLNEVPRALQDLAMLRTLDLGENQ 500
            ::......:..|.|:||.:.::||:...... |:.||||.|:|.|||.|:..:..|:.:||..|:
 Worm   372 EVLPENSKIGNLRLSNNSLELLEPSSLSGLK-LESLDLSHNKLTEVPAAIGKVEQLKKVDLSHNR 435

  Fly   501 IRTFDNQSFKNLHQLTGLRLIDNQIGNITVGMFQDLPRLSVLNLAKNRIQSIERGSFDKNFELEA 565
            |..........:.||..:.|.:||:.:|...:|.|...|..|:::.|.|..:.:.:|.:..:|..
 Worm   436 IAKVYQYVLNKIKQLHTVDLSNNQLQSIGPYIFSDSSELHSLDVSNNEISLLFKDAFARCPKLRK 500

  Fly   566 IRLDRNFLADINGVFATLVSLLWLNLSENHLVWFDYAFIPSNLKWLDIHGNYIEALGNYYKLQEE 630
            |.:..|.:..::........|..|::|.|.::...::.:|.||:.|:...|.|..|.........
 Worm   501 ISMKMNKIKSLDEGLTEASGLRRLDVSHNEILVLKWSALPENLEILNADNNDINLLTAASMSPST 565

  Fly   631 IRVKTLDASHNRITEIGPMSIPNTIELLFINNNLIGNVQPNAFVDKANLARVDLYANQLSKLQLQ 695
            ..:|::..|:|.||.:....|||::|.|.::||.:..:...|...|:.|.|::|..|.|:.:..:
 Worm   566 ANLKSVSLSNNGITIMNADQIPNSLESLDVSNNRLAKLGKTALAAKSQLRRLNLKGNLLTVVATE 630

  Fly   696 QLRVAPVVAPKPLPEFYLGGNPFECDCTMDWLQRINNLTTRQHPRVM--DMANIECVMPHARGAA 758
            .::|...|.|..:.   :..||..|||.|.|      :.....|:|:  |.....|  .||....
 Worm   631 SMKVVEAVHPLKVE---ISENPLICDCQMGW------MIGGAKPKVLIQDSETASC--SHAVDGH 684

  Fly   759 VRPLSGLRPQDFLCRYESHCFALCHCCDFDACDCEMTCPSNCTCYHDQIWSTNVVDCGGQQTTEL 823
            ...:..|..:|.||.|:|.|...|.||.:..|||:..||:||.|:.|..::.|:|.|.| .::.:
 Worm   685 QIQIQSLSKKDLLCPYKSVCEPECICCQYGNCDCKSVCPANCRCFRDDQFNINIVRCHG-NSSMV 748

  Fly   824 PRR------VPMDSSVVYLDGNNFPVLKNHAFIGRKNLRALYVNGSQVAAIQNRTFASLASLQLL 882
            |:|      :|:.::.:.|.|...|.|:.|:||||..|:.|::||:.:.:||.:.|.:|.:|:.|
 Worm   749 PKREFVVSELPVSATEIILSGVTLPQLRTHSFIGRLRLQRLHINGTGLRSIQPKAFHTLPALKTL 813

  Fly   883 HLADNKLRTLHGYEFEQLSALRELYLQNNQLTTIENATLAPLAALELIRIDGNRLVTLPIWQMHA 947
            .|:||.|.:|.|.||.:...:.:|:|..|:.:|:.......|..|:.:.:..|.|..:|    ..
 Worm   814 DLSDNSLISLSGEEFLKCGEVSQLFLNGNRFSTLSRGIFEKLPNLKYLTLHNNSLEDIP----QV 874

  Fly   948 THFGTRLKSISLGRNQWSCRC-----QFLQ-----ALTSYVADNAL--------IVQDAQDIYC- 993
            .| .|.|..|||..|...|.|     |.|.     ....:...||.        :|.|...:.| 
 Worm   875 LH-STALSKISLSSNPLRCDCSGGSQQHLHHRRDPKAHPFWEHNAAEWFSLHRHLVVDFPKVECW 938

  Fly   994 ---MAASSGTGSAALEDSSSNSGS------LEKRELDFNATGAACTDYYSG--GSMLQHGIPESY 1047
               ..|.....:..|.....|.|:      :|:...|:|:|  .|..:.||  |...|:.|  .:
 Worm   939 ENVTKAFLTNDTTVLSAYPPNMGNDVFVMPIEEFLRDYNST--ICVPFSSGFFGQDPQNSI--LF 999

  Fly  1048 IPLLAAALALLFLLVVIAMVFAFRESLRIWLFAHYGV-----RVFGPRCEESE---------KLY 1098
            :.:..:...||.:||::|:.| .|:|       |..:     :.....|..|.         ..|
 Worm  1000 VIITISIAVLLCVLVILAISF-IRKS-------HDAINQRRYKASSLNCSTSAGSSPLPVPLLSY 1056

  Fly  1099 DAVLLHSAKDSEFVCQHLAAQLETGRPPLRVCLQHRD------LAHDATHYQLLEATRVSRRVVI 1157
            .|.:.:|.||.:.|...|...||.  ...::||.|||      ..| |...:|:.....|:.:::
 Worm  1057 HAFVSYSKKDEKMVIDQLCRPLED--EDYQLCLLHRDGPTYCSNLH-AISDELIAQMDSSQCLIL 1118

  Fly  1158 LLTRNFLQTEWARCELRRSVHDALRGRPQKLVIIEEPEVAFEAESDIELLPYLKTSAVHRIRRSD 1222
            :||::||:.||...:::.|.....:.|.::::.:....|......| ||...|:...  ||....
 Worm  1119 VLTKHFLENEWKTLQIKTSHQLFAKNRAKRVIAVLGDGVDANLLDD-ELGQILRKHT--RIEMRS 1180

  Fly  1223 RHFWEKLRYALPVDYP 1238
            ..||..|..:||...|
 Worm  1181 HLFWTLLHSSLPSRLP 1196

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-7NP_523797.1 LRR_8 135..201 CDD:290566 17/65 (26%)
leucine-rich repeat 136..159 CDD:275380 7/22 (32%)
leucine-rich repeat 160..190 CDD:275380 7/29 (24%)
LRR_8 189..259 CDD:290566 18/69 (26%)
leucine-rich repeat 191..214 CDD:275380 6/22 (27%)
leucine-rich repeat 215..248 CDD:275380 8/32 (25%)
LRR_RI 247..501 CDD:238064 74/272 (27%)
LRR_8 247..308 CDD:290566 23/79 (29%)
leucine-rich repeat 249..273 CDD:275380 8/24 (33%)
leucine-rich repeat 274..297 CDD:275380 8/36 (22%)
LRR_8 297..356 CDD:290566 18/62 (29%)
leucine-rich repeat 298..321 CDD:275380 8/26 (31%)
leucine-rich repeat 322..345 CDD:275380 4/22 (18%)
LRR_8 345..406 CDD:290566 12/60 (20%)
leucine-rich repeat 346..371 CDD:275380 7/24 (29%)
leucine-rich repeat 372..395 CDD:275380 2/22 (9%)
leucine-rich repeat 396..419 CDD:275380 5/22 (23%)
LRR_8 419..478 CDD:290566 20/58 (34%)
leucine-rich repeat 420..443 CDD:275380 7/22 (32%)
leucine-rich repeat 444..467 CDD:275380 6/22 (27%)
LRR_RI 466..622 CDD:238064 42/155 (27%)
leucine-rich repeat 468..488 CDD:275380 11/19 (58%)
LRR_8 491..549 CDD:290566 16/57 (28%)
leucine-rich repeat 491..514 CDD:275380 5/22 (23%)
leucine-rich repeat 515..536 CDD:275380 6/20 (30%)
leucine-rich repeat 539..562 CDD:275380 5/22 (23%)
leucine-rich repeat 563..585 CDD:275380 3/21 (14%)
leucine-rich repeat 586..626 CDD:275380 11/39 (28%)
leucine-rich repeat 627..653 CDD:275380 6/25 (24%)
LRRCT 716..772 CDD:214507 15/57 (26%)
LRRNT 796..830 CDD:214470 13/39 (33%)
leucine-rich repeat 812..829 CDD:275380 5/22 (23%)
leucine-rich repeat 833..854 CDD:275380 9/20 (45%)
LRR_8 853..913 CDD:290566 21/59 (36%)
leucine-rich repeat 855..878 CDD:275380 8/22 (36%)
LRR_4 878..918 CDD:289563 14/39 (36%)
leucine-rich repeat 879..902 CDD:275380 10/22 (45%)
leucine-rich repeat 903..926 CDD:275380 5/22 (23%)
leucine-rich repeat 927..953 CDD:275380 5/25 (20%)
TIR 1098..1235 CDD:214587 37/142 (26%)
tol-1NP_001020983.1 leucine-rich repeat 71..95 CDD:275380 8/35 (23%)
leucine-rich repeat 96..119 CDD:275380 7/22 (32%)
leucine-rich repeat 120..171 CDD:275380 13/53 (25%)
leucine-rich repeat 172..195 CDD:275380 8/32 (25%)
leucine-rich repeat 196..283 CDD:275380 26/90 (29%)
leucine-rich repeat 219..240 CDD:275378 5/23 (22%)
leucine-rich repeat 241..258 CDD:275378 5/16 (31%)
LRR 265..600 CDD:227223 94/362 (26%)
leucine-rich repeat 287..306 CDD:275380 3/18 (17%)
leucine-rich repeat 307..331 CDD:275380 7/29 (24%)
leucine-rich repeat 332..355 CDD:275380 7/41 (17%)
leucine-rich repeat 356..379 CDD:275380 7/22 (32%)
leucine-rich repeat 380..395 CDD:275380 4/14 (29%)
leucine-rich repeat 403..425 CDD:275380 11/21 (52%)
leucine-rich repeat 426..449 CDD:275380 5/22 (23%)
leucine-rich repeat 450..473 CDD:275380 7/22 (32%)
leucine-rich repeat 474..497 CDD:275380 5/22 (23%)
leucine-rich repeat 498..520 CDD:275380 3/21 (14%)
leucine-rich repeat 543..567 CDD:275380 5/23 (22%)
leucine-rich repeat 568..589 CDD:275380 7/20 (35%)
leucine-rich repeat 590..613 CDD:275380 6/22 (27%)
leucine-rich repeat 614..633 CDD:275380 5/18 (28%)
leucine-rich repeat 763..785 CDD:275378 9/21 (43%)
LRR_8 785..844 CDD:338972 21/58 (36%)
leucine-rich repeat 786..809 CDD:275378 8/22 (36%)
LRR_9 <806..>890 CDD:373143 27/88 (31%)
leucine-rich repeat 810..833 CDD:275378 10/22 (45%)
leucine-rich repeat 834..857 CDD:275378 5/22 (23%)
leucine-rich repeat 858..879 CDD:275378 5/25 (20%)
leucine-rich repeat 880..892 CDD:275378 5/11 (45%)
TIR_2 1056..1194 CDD:390066 38/143 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 132 1.000 Domainoid score I3176
eggNOG 1 0.900 - - E2759_KOG4641
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H134358
Inparanoid 1 1.050 370 1.000 Inparanoid score I1230
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG28754
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 1 1.000 - - FOG0006722
OrthoInspector 1 1.000 - - otm14097
orthoMCL 1 0.900 - - OOG6_104126
Panther 1 1.100 - - O PTHR24373
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X221
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1514.840

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