DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-7 and Cd180

DIOPT Version :9

Sequence 1:	NP_523797.1	Gene:	Toll-7 / 37272	FlyBaseID:	FBgn0034476	Length:	1446	Species:	Drosophila melanogaster
Sequence 2:	NP_032559.2	Gene:	Cd180 / 17079	MGIID:	1194924	Length:	661	Species:	Mus musculus

Alignment Length:	695	Identity:	159/695 - (22%)
Similarity:	275/695 - (39%)	Gaps:	156/695 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   136 LEALRLDSCKLLQLPNNAFEGLATLKSLRL-------STHNSEWGPTRTLELFPDSLGGLKQLTD 193
            |.||.|.||:            ||..|.:.       .|:|.|   ...|...|   |.|...|:
Mouse    10 LVALFLASCR------------ATTSSDQKCIEKEVNKTYNCE---NLGLNEIP---GTLPNSTE 56

  Fly   194 -LDLGDNNLRQLPSGFLCPVGNLQVLNLTRNRIRTAEQMGFADMNCGAGSGSAGSELQVLDASHN 257
             |:...|.|..:.:.....:.||..|:|||.:|....:..|...:          .|..|..:.|
Mouse    57 CLEFSFNVLPTIQNTTFSRLINLTFLDLTRCQIYWIHEDTFQSQH----------RLDTLVLTAN 111

  Fly   258 ELRSISESWGISRLRRLQHLNLAYNNLSELSGEALAGLASLRIVNLSNNHLET--LPEGLFAGSK 320
            .|..::|: .:|..:.|:||......:|.:....|....:|..:.|.:||:.:  ||:|.  .::
Mouse   112 PLIFMAET-ALSGPKALKHLFFIQTGISSIDFIPLHNQKTLESLYLGSNHISSIKLPKGF--PTE 173

  Fly   321 ELREIHLQQNELYELPKGLFHRLEQL--LVVDLSGNQLT--------SNHVDNTTFAGLIRLIVL 375
            :|:.:..|.|.::.|.|.....|:|.  |.::|:||.:.        |....:..|.|...|:|:
Mouse   174 KLKVLDFQNNAIHYLSKEDMSSLQQATNLSLNLNGNDIAGIELGAFDSAVFQSLNFGGTQNLLVI 238

  Fly   376 --NLAHNALTRIDYRTFKEL---------------YFLQILNLRNNSIGHIEDNAFLPLYNLHTL 423
              .|.::.:..:...||:::               ..::.:||:.:...:|..|.|.....|..|
Mouse   239 FKGLKNSTIQSLWLGTFEDMDDEDISPAVFEGLCEMSVESINLQKHYFFNISSNTFHCFSGLQEL 303

  Fly   424 NLAENRLHTLDDKLFNGLYVLSKLTLNNNLISVVEPAVFKNCSDLKELDLSSN--QLNEVPRALQ 486
            :|....|..|...|. ||..|.||.|:.|....:......|...|..|.:..|  :|......|:
Mouse   304 DLTATHLSELPSGLV-GLSTLKKLVLSANKFENLCQISASNFPSLTHLSIKGNTKRLELGTGCLE 367

  Fly   487 DLAMLRTLDLGENQIRTFD--NQSFKNLHQLTGLRLIDNQIGNITVGMFQDLPRLSVLNLAKNRI 549
            :|..||.|||..:.|.|.|  |...:||..|..|.|..|:..::....|::.|:|.:|:||..|:
Mouse   368 NLENLRELDLSHDDIETSDCCNLQLRNLSHLQSLNLSYNEPLSLKTEAFKECPQLELLDLAFTRL 432

  Fly   550 QSIERGSFDKNFE-LEAIRLDRNFLADING--VFATLVSLLWLNLSENHLVWFDYAFIPSNLKWL 611
            :..:..|..:|.. |:.:.|..:.| ||:.  :|..|.:|..|||..||       |...|::
Mouse   433 KVKDAQSPFQNLHLLKVLNLSHSLL-DISSEQLFDGLPALQHLNLQGNH-------FPKGNIQ-- 487

  Fly   612 DIHGNYIEALGNYYKLQEEIRVKTLDASHNRITEIGPMSIPNTIELLFINNNLIGNVQPNAFVDK 676
              ..|.::.||.                               :|:|.::...:.::..:||...
Mouse   488 --KTNSLQTLGR-------------------------------LEILVLSFCDLSSIDQHAFTSL 519

  Fly   677 ANLARVDLYANQLSKLQLQQL-------------RVAPVVAPKPLP------EFYLGGNPFECDC 722
            ..:..|||..|:|:...::.|             |:: ::.|..||      ...|..||.:|.|
Mouse   520 KMMNHVDLSHNRLTSSSIEALSHLKGIYLNLASNRIS-IILPSLLPILSQQRTINLRQNPLDCTC 583

  Fly   723 T----MDW----LQRINNL--TTRQHP------RVMDMANIECVM 751
            :    ::|    :|::.:.  |..::|      |:.|: .:.|.|
Mouse   584 SNIYFLEWYKENMQKLEDTEDTLCENPPLLRGVRLSDV-TLSCSM 627

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-7	NP_523797.1	LRR_8	135..201	CDD:290566	19/72 (26%)
		leucine-rich repeat	136..159	CDD:275380	6/22 (27%)
		leucine-rich repeat	160..190	CDD:275380	8/36 (22%)
		LRR_8	189..259	CDD:290566	15/70 (21%)
		leucine-rich repeat	191..214	CDD:275380	4/23 (17%)
		leucine-rich repeat	215..248	CDD:275380	7/32 (22%)
		LRR_RI	247..501	CDD:238064	67/284 (24%)
		LRR_8	247..308	CDD:290566	14/60 (23%)
		leucine-rich repeat	249..273	CDD:275380	6/23 (26%)
		leucine-rich repeat	274..297	CDD:275380	5/22 (23%)
		LRR_8	297..356	CDD:290566	18/62 (29%)
		leucine-rich repeat	298..321	CDD:275380	7/24 (29%)
		leucine-rich repeat	322..345	CDD:275380	6/22 (27%)
		LRR_8	345..406	CDD:290566	15/87 (17%)
		leucine-rich repeat	346..371	CDD:275380	7/34 (21%)
		leucine-rich repeat	372..395	CDD:275380	5/39 (13%)
		leucine-rich repeat	396..419	CDD:275380	5/22 (23%)
		LRR_8	419..478	CDD:290566	17/60 (28%)
		leucine-rich repeat	420..443	CDD:275380	8/22 (36%)
		leucine-rich repeat	444..467	CDD:275380	6/22 (27%)
		LRR_RI	466..622	CDD:238064	46/162 (28%)
		leucine-rich repeat	468..488	CDD:275380	5/21 (24%)
		LRR_8	491..549	CDD:290566	21/59 (36%)
		leucine-rich repeat	491..514	CDD:275380	11/24 (46%)
		leucine-rich repeat	515..536	CDD:275380	5/20 (25%)
		leucine-rich repeat	539..562	CDD:275380	7/22 (32%)
		leucine-rich repeat	563..585	CDD:275380	7/23 (30%)
		leucine-rich repeat	586..626	CDD:275380	11/39 (28%)
		leucine-rich repeat	627..653	CDD:275380	0/25 (0%)
		LRRCT	716..772	CDD:214507	12/52 (23%)
		LRRNT	796..830	CDD:214470
		leucine-rich repeat	812..829	CDD:275380
		leucine-rich repeat	833..854	CDD:275380
		LRR_8	853..913	CDD:290566
		leucine-rich repeat	855..878	CDD:275380
		LRR_4	878..918	CDD:289563
		leucine-rich repeat	879..902	CDD:275380
		leucine-rich repeat	903..926	CDD:275380
		leucine-rich repeat	927..953	CDD:275380
		TIR	1098..1235	CDD:214587
Cd180	NP_032559.2	leucine-rich repeat	38..57	CDD:275380	7/24 (29%)
		LRR 1	54..75		4/20 (20%)
		leucine-rich repeat	58..78	CDD:275380	3/19 (16%)
		LRR 2	78..99		8/20 (40%)
		leucine-rich repeat	79..102	CDD:275380	7/32 (22%)
		LRR 3	102..123		5/21 (24%)
		leucine-rich repeat	103..126	CDD:275380	6/23 (26%)
		LRR 4	126..147		5/20 (25%)
		leucine-rich repeat	127..150	CDD:275380	5/22 (23%)
		LRR 5	150..171		7/22 (32%)
		leucine-rich repeat	151..174	CDD:275380	7/24 (29%)
		LRR 6	174..195		5/20 (25%)
		leucine-rich repeat	175..201	CDD:275380	7/25 (28%)
		LRR 7	201..221		4/19 (21%)
		leucine-rich repeat	224..275	CDD:275380	7/50 (14%)
		LRR 8	275..296		5/20 (25%)
		leucine-rich repeat	276..299	CDD:275380	5/22 (23%)
		LRR 9	299..321		7/22 (32%)
		leucine-rich repeat	300..322	CDD:275380	8/22 (36%)
		LRR_8	321..382	CDD:290566	17/60 (28%)
		LRR 10	322..343		5/20 (25%)
		leucine-rich repeat	323..346	CDD:275380	6/22 (27%)
		LRR_RI	345..>541	CDD:238064	57/238 (24%)
		LRR 11	346..366		4/19 (21%)
		leucine-rich repeat	347..371	CDD:275380	6/23 (26%)
		LRR_8	371..432	CDD:290566	21/60 (35%)
		LRR 12	371..391		9/19 (47%)
		leucine-rich repeat	372..397	CDD:275380	11/24 (46%)
		LRR 13	397..418		5/20 (25%)
		leucine-rich repeat	398..421	CDD:275380	5/22 (23%)
		LRR_8	420..481	CDD:290566	21/68 (31%)
		LRR 14	421..442		6/20 (30%)
		leucine-rich repeat	422..446	CDD:275380	7/23 (30%)
		LRR 15	446..466		5/20 (25%)
		leucine-rich repeat	447..470	CDD:275380	7/23 (30%)
		LRR 16	470..493		9/33 (27%)
		leucine-rich repeat	471..497	CDD:275380	10/36 (28%)
		LRR_8	497..555	CDD:290566	10/88 (11%)
		LRR 17	497..518		4/51 (8%)
		leucine-rich repeat	498..521	CDD:275380	4/22 (18%)
		LRR 18	521..544		6/22 (27%)
		leucine-rich repeat	522..545	CDD:275380	6/22 (27%)
		LRR 19	546..566		4/20 (20%)
		LRRCT	577..626	CDD:214507	10/49 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010