DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Toll-7 and Tlr8

DIOPT Version :9

Sequence 1:NP_523797.1 Gene:Toll-7 / 37272 FlyBaseID:FBgn0034476 Length:1446 Species:Drosophila melanogaster
Sequence 2:NP_573475.2 Gene:Tlr8 / 170744 MGIID:2176887 Length:1032 Species:Mus musculus


Alignment Length:751 Identity:192/751 - (25%)
Similarity:321/751 - (42%) Gaps:151/751 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    95 ERQPGLDL-QGA----DGSSQLTIQCSELYLFESTLPVAVFARLQTLEALRLDSCKLLQLPNNAF 154
            |.:.|::: :||    ...:.|.::.::||...:.||       ::|:.|.|....:.|:..|..
Mouse   105 ENKNGMNITEGALLSLRNLTVLLLEDNQLYTIPAGLP-------ESLKELSLIQNNIFQVTKNNT 162

  Fly   155 EGLATLKSLRLSTHNSEWGPTRTLELFPDSLGGLKQLTDLDLGDNNL----RQLPSG----FLCP 211
            .||..|:.|.|. .|..:...:|.::...:...|..|..|.|..|||    .:|||.    ||  
Mouse   163 FGLRNLERLYLG-WNCYFKCNQTFKVEDGAFKNLIHLKVLSLSFNNLFYVPPKLPSSLRKLFL-- 224

  Fly   212 VGNLQVLNLTRNRIRTAEQMGFADMN---------------CGAGSG--------SAGSELQVLD 253
             .|.:::|:|:...:..|.:...|::               |...|.        .:.::|..|:
Mouse   225 -SNAKIMNITQEDFKGLENLTLLDLSGNCPRCYNAPFPCTPCKENSSIHIHPLAFQSLTQLLYLN 288

  Fly   254 ASHNELRSISESWGISRLRRLQHLNLAYNNLSE--LSGEALAGLASLRIVNLSNNHLETLPEGLF 316
            .|...||:|..:| ...|..|:.|:|.:|.|.:  .||..|..|.||:|::||.|         |
Mouse   289 LSSTSLRTIPSTW-FENLSNLKELHLEFNYLVQEIASGAFLTKLPSLQILDLSFN---------F 343

  Fly   317 AGSKELREIHLQQNELYELPKGLFHRLEQLLVVDLSG---NQLTSNHVDNTTFAGLIRLIVLNLA 378
            ...:.|:.|::..|         |.:|..|..:.|.|   .:|...|.::  ...|..|..:||.
Mouse   344 QYKEYLQFINISSN---------FSKLRSLKKLHLRGYVFRELKKKHFEH--LQSLPNLATINLG 397

  Fly   379 HNALTRIDYRTFKELYFLQILNLRNNSIGHIEDNAFLPLYNLHTLNLAENRLH---TLDDKLFN- 439
            .|.:.:||::.|:....|.::.|..|.|..:.|......:        .|||.   :.||..|: 
Mouse   398 INFIEKIDFKAFQNFSKLDVIYLSGNRIASVLDGTDYSSW--------RNRLRKPLSTDDDEFDP 454

  Fly   440 --GLYVLSK---------------LTLNNNLISVVEPAVFKNCSDLKELDLSSNQLNEVPRALQD 487
              ..|..:|               |:|||  |.::..:.|:...|:..|:||.|...:|....:.
Mouse   455 HVNFYHSTKPLIKPQCTAYGKALDLSLNN--IFIIGKSQFEGFQDIACLNLSFNANTQVFNGTEF 517

  Fly   488 LAM--LRTLDLGENQIRTFDNQSFKNLHQLTGLRLIDN----QIGNIT--VGMFQDLPRLSVLNL 544
            .:|  ::.|||..|::...||.:|.:||.|..|.|..|    .|..:|  :|..|:|..|.||||
Mouse   518 SSMPHIKYLDLTNNRLDFDDNNAFSDLHDLEVLDLSHNAHYFSIAGVTHRLGFIQNLINLRVLNL 582

  Fly   545 AKNRIQSIERGSFDKNFELEAI-----RLDRNFLADIN---GVFATLVSLLWLNLSENHLVWF-D 600
            :.|.|.::...|..|:..|:.:     ||||.:.|:..   .:|.:|.:|:.|:||.|:|... :
Mouse   583 SHNGIYTLTEESELKSISLKELVFSGNRLDRLWNANDGKYWSIFKSLQNLIRLDLSYNNLQQIPN 647

  Fly   601 YAF--IPSNLKWLDIHGNYIEALGNYYKLQEEIRVKTLDASHNRITEIGPMSIPN-------TIE 656
            .||  :|.:|:.|.|.||.:... |:..||....:..||.|.|.:     ..:||       ::|
Mouse   648 GAFLNLPQSLQELLISGNKLRFF-NWTLLQYFPHLHLLDLSRNEL-----YFLPNCLSKFAHSLE 706

  Fly   657 LLFINNNLIGNVQPNAFVDKA-NLARVDLYANQLSKLQLQQLRVAPVVAPKPLPEFYLGGNPFEC 720
            .|.:::|...:: |:.|:.:| ||..:||..|.:..:....|:..   ....|....|.||.|:|
Mouse   707 TLLLSHNHFSHL-PSGFLSEARNLVHLDLSFNTIKMINKSSLQTK---MKTNLSILELHGNYFDC 767

  Fly   721 DCTM----DWLQRINNLTTRQHPRVMDMANIECVMP 752
            .|.:    .||....|:|      :..:.|:.|..|
Mouse   768 TCDISDFRSWLDENLNIT------IPKLVNVICSNP 797

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-7NP_523797.1 LRR_8 135..201 CDD:290566 17/65 (26%)
leucine-rich repeat 136..159 CDD:275380 7/22 (32%)
leucine-rich repeat 160..190 CDD:275380 6/29 (21%)
LRR_8 189..259 CDD:290566 21/100 (21%)
leucine-rich repeat 191..214 CDD:275380 11/30 (37%)
leucine-rich repeat 215..248 CDD:275380 6/55 (11%)
LRR_RI 247..501 CDD:238064 72/281 (26%)
LRR_8 247..308 CDD:290566 23/62 (37%)
leucine-rich repeat 249..273 CDD:275380 8/23 (35%)
leucine-rich repeat 274..297 CDD:275380 9/24 (38%)
LRR_8 297..356 CDD:290566 15/61 (25%)
leucine-rich repeat 298..321 CDD:275380 6/22 (27%)
leucine-rich repeat 322..345 CDD:275380 5/22 (23%)
LRR_8 345..406 CDD:290566 16/63 (25%)
leucine-rich repeat 346..371 CDD:275380 6/27 (22%)
leucine-rich repeat 372..395 CDD:275380 7/22 (32%)
leucine-rich repeat 396..419 CDD:275380 5/22 (23%)
LRR_8 419..478 CDD:290566 19/79 (24%)
leucine-rich repeat 420..443 CDD:275380 6/28 (21%)
leucine-rich repeat 444..467 CDD:275380 7/37 (19%)
LRR_RI 466..622 CDD:238064 56/174 (32%)
leucine-rich repeat 468..488 CDD:275380 5/19 (26%)
LRR_8 491..549 CDD:290566 24/63 (38%)
leucine-rich repeat 491..514 CDD:275380 8/22 (36%)
leucine-rich repeat 515..536 CDD:275380 8/26 (31%)
leucine-rich repeat 539..562 CDD:275380 9/22 (41%)
leucine-rich repeat 563..585 CDD:275380 8/29 (28%)
leucine-rich repeat 586..626 CDD:275380 15/42 (36%)
leucine-rich repeat 627..653 CDD:275380 6/25 (24%)
LRRCT 716..772 CDD:214507 11/41 (27%)
LRRNT 796..830 CDD:214470
leucine-rich repeat 812..829 CDD:275380
leucine-rich repeat 833..854 CDD:275380
LRR_8 853..913 CDD:290566
leucine-rich repeat 855..878 CDD:275380
LRR_4 878..918 CDD:289563
leucine-rich repeat 879..902 CDD:275380
leucine-rich repeat 903..926 CDD:275380
leucine-rich repeat 927..953 CDD:275380
TIR 1098..1235 CDD:214587
Tlr8NP_573475.2 LRR_RI 32..252 CDD:238064 38/157 (24%)
LRR 1 41..61
LRR 2 62..85
LRR_8 65..133 CDD:290566 5/27 (19%)
leucine-rich repeat 65..88 CDD:275380
LRR 3 87..109 1/3 (33%)
leucine-rich repeat 89..122 CDD:275380 4/16 (25%)
LRR 4 120..143 5/29 (17%)
leucine-rich repeat 123..143 CDD:275380 5/26 (19%)
leucine-rich repeat 144..167 CDD:275380 7/22 (32%)
LRR 5 145..165 4/19 (21%)
LRR_8 166..251 CDD:290566 22/88 (25%)
LRR 6 166..194 5/28 (18%)
leucine-rich repeat 168..197 CDD:275380 6/29 (21%)
LRR 7 195..218 9/22 (41%)
leucine-rich repeat 198..218 CDD:275380 8/19 (42%)
leucine-rich repeat 219..242 CDD:275380 5/25 (20%)
LRR 8 220..239 5/21 (24%)
LRR 9 240..267 3/26 (12%)
leucine-rich repeat 243..283 CDD:275380 3/39 (8%)
LRR_RI <277..>428 CDD:238064 46/171 (27%)
LRR 10 281..304 7/23 (30%)
LRR_8 282..342 CDD:290566 22/60 (37%)
leucine-rich repeat 284..307 CDD:275380 8/23 (35%)
LRR 11 306..329 7/22 (32%)
leucine-rich repeat 308..327 CDD:275380 7/18 (39%)
LRR 12 331..360 12/46 (26%)
leucine-rich repeat 334..363 CDD:275380 11/46 (24%)
LRR 13 361..384 6/22 (27%)
LRR_8 362..425 CDD:290566 16/64 (25%)
leucine-rich repeat 364..390 CDD:275380 6/27 (22%)
LRR 14 388..411 8/22 (36%)
leucine-rich repeat 391..414 CDD:275380 7/22 (32%)
LRR 15 413..436 5/22 (23%)
leucine-rich repeat 465..497 CDD:275380 6/33 (18%)
LRR 16 471..494 6/24 (25%)
LRR_8 475..533 CDD:290566 17/59 (29%)
leucine-rich repeat 501..522 CDD:275380 6/20 (30%)
LRR 17 520..543 8/22 (36%)
LRR_8 521..587 CDD:290566 24/65 (37%)
leucine-rich repeat 523..546 CDD:275380 8/22 (36%)
LRR 18 545..572 8/26 (31%)
LRR_RI 546..765 CDD:238064 65/228 (29%)
leucine-rich repeat 547..576 CDD:275380 9/28 (32%)
LRR 19 574..598 9/23 (39%)
leucine-rich repeat 577..600 CDD:275380 9/22 (41%)
LRR_8 600..667 CDD:290566 22/66 (33%)
LRR 20 600..621 6/20 (30%)
leucine-rich repeat 601..631 CDD:275380 8/29 (28%)
LRR 21 629..652 9/22 (41%)
leucine-rich repeat 632..656 CDD:275380 9/23 (39%)
LRR 22 654..677 8/23 (35%)
leucine-rich repeat 657..680 CDD:275380 8/23 (35%)
LRR 23 678..701 6/27 (22%)
LRR_8 679..737 CDD:290566 16/63 (25%)
leucine-rich repeat 681..704 CDD:275380 6/27 (22%)
LRR 24 702..725 5/23 (22%)
leucine-rich repeat 705..728 CDD:275380 6/23 (26%)
LRR 25 727..749 6/21 (29%)
leucine-rich repeat 729..748 CDD:275380 4/18 (22%)
LRR 26 752..776 7/23 (30%)
TIR 871..1007 CDD:214587
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4641
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.820

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