DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-7 and Tlr7

DIOPT Version :9

Sequence 1:	NP_523797.1	Gene:	Toll-7 / 37272	FlyBaseID:	FBgn0034476	Length:	1446	Species:	Drosophila melanogaster
Sequence 2:	NP_001277687.1	Gene:	Tlr7 / 170743	MGIID:	2176882	Length:	1053	Species:	Mus musculus

Alignment Length:	1170	Identity:	258/1170 - (22%)
Similarity:	434/1170 - (37%)	Gaps:	308/1170 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   194 LDLGDNNLRQLPSGFLCPVGNLQVLNLTRNRIRTAEQMGFADMNCGAGSGSAGSELQVLDASHNE 258
            :|..|.:|.::|.|.  |. |...|.||.|.|.:.....|
Mouse    52 VDCTDKHLTEIPEGI--PT-NTTNLTLTINHIPSISPDSF------------------------- 88

  Fly   259 LRSISESWGISRLRRLQHLNLAYNNLSELSGEALAGLASLRIVNLSNNHLETLPEGLFAGSKELR 323
                      .||..|:.::|..|.:..|.|..         .|:....|:..| |.|:|..:|:
Mouse    89 ----------RRLNHLEEIDLRCNCVPVLLGSK---------ANVCTKRLQIRP-GSFSGLSDLK 133

  Fly   324 EIHLQQNELYELPKGLFHRLEQLLVVDLSGNQLTSNHVDNTTFAGLIRLIVLNLAHNALTR---- 384
            .::|..|:|.|:|:.|   ...|.::.|..|.:.|...:|.|  .|:.:..|.|..|...|
Mouse   134 ALYLDGNQLLEIPQDL---PSSLHLLSLEANNIFSITKENLT--ELVNIETLYLGQNCYYRNPCN 193

  Fly   385 IDYRTFKELYF----LQILNLR---------------------NNSIGHIEDNAFLPLYNLHTLN 424
            :.|...|:.:.    |::|:|:                     ||.|..|::|.|..|..|..|:
Mouse   194 VSYSIEKDAFLVMRNLKVLSLKDNNVTAVPTTLPPNLLELYLYNNIIKKIQENDFNNLNELQVLD 258

  Fly   425 LAEN--------------------RLHTLDDKLFNGLYVLSKLTLNNNLISVVEPAVFKNCSDLK 469
            |:.|                    ::|   |..||.|..|..|.|::|.:..|.|..|||..:|:
Mouse   259 LSGNCPRCYNVPYPCTPCENNSPLQIH---DNAFNSLTELKVLRLHSNSLQHVPPTWFKNMRNLQ 320

  Fly   470 ELDLSSNQL-NEVPRA--LQDLAMLRTLDLGEN-QIRTFD-----NQSFKNLHQLTGLRL---ID 522
            |||||.|.| .|:..|  |..|..|..||...| :::.:.     ..|..:|..|..||:   :.
Mouse   321 ELDLSQNYLAREIEEAKFLHFLPNLVELDFSFNYELQVYHASITLPHSLSSLENLKILRVKGYVF 385

  Fly   523 NQIGNITVGMFQDLPRLSVLNLAKNRIQSIERGSFDKNFELEAIRLDRNFLADINGVFATLVSLL 587
            .::.|.::.:...||||.||:|..|.|:                      :||:| :|....:|.
Mouse   386 KELKNSSLSVLHKLPRLEVLDLGTNFIK----------------------IADLN-IFKHFENLK 427

  Fly   588 WLNLSENHL----VWFDYAFIPSNLKWLDIHG-NYIEALGNYYKLQEEIRV-------------- 633
            .::||.|.:    ...:..|.|:....:|.|| ..:||| :|::..|..|.
Mouse   428 LIDLSVNKISPSEESREVGFCPNAQTSVDRHGPQVLEAL-HYFRYDEYARSCRFKNKEPPSFLPL 491

  Fly   634 --------KTLDASHNRITEIGPMSIPNT--IELLFINNNLIGN---------VQPNAFVDKANL 679
                    :|||.|.|.|..|.|....:.  ::.|.::.|.||.         ::...::|.:|
Mouse   492 NADCHIYGQTLDLSRNNIFFIKPSDFQHLSFLKCLNLSGNTIGQTLNGSELWPLRELRYLDFSN- 555

  Fly   680 ARVD-LYANQLSKLQLQQLRVAPVVAPKPLPEFYLGGNPFECDCTMDWLQRINNLTTRQHPRVMD 743
            .|:| ||:....  :||.|.|..:.:         ..:.|:.    :.:..:.|.|.:.  |::|
Mouse   556 NRLDLLYSTAFE--ELQSLEVLDLSS---------NSHYFQA----EGITHMLNFTKKL--RLLD 603

  Fly   744 --MANIECVMPHARGAAVRPLSGLRPQDFLCRYESHCFALCHCCDFDACDCEMTCPSNCTCYHDQ 806
              |.|...:...|  :.......||..:|   ..:|...|....|....|           :...
Mouse   604 KLMMNDNDISTSA--SRTMESDSLRILEF---RGNHLDVLWRAGDNRYLD-----------FFKN 652

  Fly   807 IWSTNVVDCGGQQTTELPRRVPMDSSVVYLDG-----NNFPVLKN---HAFIGR----KNLRALY 859
            :::..|:|........||..|        .:|     .|..:.||   ..|..|    |:|..|.
Mouse   653 LFNLEVLDISRNSLNSLPPEV--------FEGMPPNLKNLSLAKNGLKSFFWDRLQLLKHLEILD 709

  Fly   860 VNGSQVAAIQNRTFASLASLQLLHLADNKLRTLHGYEFEQLSALRELYLQNNQLTTIENATLAPL 924
            ::.:|:..:..|......||..|.|..|::|.|..|..|....||.|.:.:|::..|:. |..|.
Mouse   710 LSHNQLTKVPERLANCSKSLTTLILKHNQIRQLTKYFLEDALQLRYLDISSNKIQVIQK-TSFPE 773

  Fly   925 AALELIRIDGNRLVTLPIWQMHATHFGTRLKSISLGRNQWSCRCQFLQALTSYVADNALIVQDAQ 989
            ..|                        ..|:.:.|..|::.|.|..:..:......:..|...|.
Mouse   774 NVL------------------------NNLEMLVLHHNRFLCNCDAVWFVWWVNHTDVTIPYLAT 814

  Fly   990 DIYCMAASSGTGSAALEDSSSNSGSLEKRELDFNATGAACTDYYSGGSMLQHGIPESYIPLLAAA 1054
            |:.|:...:..|.:.:      |..|...|||..                      :.|....:.
Mouse   815 DVTCVGPGAHKGQSVI------SLDLYTCELDLT----------------------NLILFSVSI 851

  Fly  1055 LALLFLLVVIAMVFAFRESLRIW----LFAHYGVRVFG-PRCEESEKLYDAVLLHSAKDS---EF 1111
            .::|||:||:.....|     .|    ::..:..::.| ...:..|..|||.:::..|:|   |:
Mouse   852 SSVLFLMVVMTTSHLF-----FWDMWYIYYFWKAKIKGYQHLQSMESCYDAFIVYDTKNSAVTEW 911

  Fly  1112 VCQHLAAQLETGRPP-LRVCLQHRD-LAHDATHYQLLEATRVSRRVVILLTRNFLQTEWARCELR 1174
            |.|.|.|:||..|.. ..:||:.|| |........|.::.::|::.|.::|:.:.:||..:....
Mouse   912 VLQELVAKLEDPREKHFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTQKYAKTESFKMAFY 976

  Fly  1175 RSVHDALRGRPQKLVIIEEPEVAFEAESDIELLPYLKTSAVHRIRRSDR---HFWEKLRYALPVD 1236
            .| |..|......::|:...|...:....::|...|..|:|.....:.:   :||:.|:.||..|
Mouse   977 LS-HQRLLDEKVDVIILIFLEKPLQKSKFLQLRKRLCRSSVLEWPANPQAHPYFWQCLKNALTTD 1040

Fly 1237 1236
Mouse 1041 1040

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-7	NP_523797.1	LRR_8	135..201	CDD:290566	2/6 (33%)
		leucine-rich repeat	136..159	CDD:275380
		leucine-rich repeat	160..190	CDD:275380
		LRR_8	189..259	CDD:290566	13/64 (20%)
		leucine-rich repeat	191..214	CDD:275380	6/19 (32%)
		leucine-rich repeat	215..248	CDD:275380	6/32 (19%)
		LRR_RI	247..501	CDD:238064	77/306 (25%)
		LRR_8	247..308	CDD:290566	8/60 (13%)
		leucine-rich repeat	249..273	CDD:275380	2/23 (9%)
		leucine-rich repeat	274..297	CDD:275380	5/22 (23%)
		LRR_8	297..356	CDD:290566	16/58 (28%)
		leucine-rich repeat	298..321	CDD:275380	6/22 (27%)
		leucine-rich repeat	322..345	CDD:275380	7/22 (32%)
		LRR_8	345..406	CDD:290566	18/89 (20%)
		leucine-rich repeat	346..371	CDD:275380	7/24 (29%)
		leucine-rich repeat	372..395	CDD:275380	6/26 (23%)
		leucine-rich repeat	396..419	CDD:275380	10/43 (23%)
		LRR_8	419..478	CDD:290566	25/78 (32%)
		leucine-rich repeat	420..443	CDD:275380	9/42 (21%)
		leucine-rich repeat	444..467	CDD:275380	9/22 (41%)
		LRR_RI	466..622	CDD:238064	46/172 (27%)
		leucine-rich repeat	468..488	CDD:275380	11/22 (50%)
		LRR_8	491..549	CDD:290566	18/66 (27%)
		leucine-rich repeat	491..514	CDD:275380	6/28 (21%)
		leucine-rich repeat	515..536	CDD:275380	4/23 (17%)
		leucine-rich repeat	539..562	CDD:275380	6/22 (27%)
		leucine-rich repeat	563..585	CDD:275380	4/21 (19%)
		leucine-rich repeat	586..626	CDD:275380	13/44 (30%)
		leucine-rich repeat	627..653	CDD:275380	10/47 (21%)
		LRRCT	716..772	CDD:214507	11/57 (19%)
		LRRNT	796..830	CDD:214470	5/33 (15%)
		leucine-rich repeat	812..829	CDD:275380	5/16 (31%)
		leucine-rich repeat	833..854	CDD:275380	6/32 (19%)
		LRR_8	853..913	CDD:290566	18/59 (31%)
		leucine-rich repeat	855..878	CDD:275380	4/22 (18%)
		LRR_4	878..918	CDD:289563	14/39 (36%)
		leucine-rich repeat	879..902	CDD:275380	8/22 (36%)
		leucine-rich repeat	903..926	CDD:275380	7/22 (32%)
		leucine-rich repeat	927..953	CDD:275380	1/25 (4%)
		TIR	1098..1235	CDD:214587	38/144 (26%)
Tlr7	NP_001277687.1	PRK15370	<35..>246	CDD:185268	53/246 (22%)
		leucine-rich repeat	51..72	CDD:275380	7/22 (32%)
		leucine-rich repeat	73..93	CDD:275380	8/54 (15%)
		leucine-rich repeat	94..131	CDD:275380	11/46 (24%)
		leucine-rich repeat	132..155	CDD:275380	8/25 (32%)
		PLN00113	177..>789	CDD:215061	157/705 (22%)
		leucine-rich repeat	177..208	CDD:275380	6/30 (20%)
		leucine-rich repeat	209..229	CDD:275380	3/19 (16%)
		leucine-rich repeat	230..253	CDD:275380	7/22 (32%)
		leucine-rich repeat	254..294	CDD:275380	9/42 (21%)
		leucine-rich repeat	295..318	CDD:275380	9/22 (41%)
		leucine-rich repeat	319..344	CDD:275380	12/24 (50%)
		leucine-rich repeat	345..401	CDD:275380	11/55 (20%)
		leucine-rich repeat	402..425	CDD:275380	10/45 (22%)
		leucine-rich repeat	500..522	CDD:275380	8/21 (38%)
		leucine-rich repeat	523..547	CDD:275380	4/23 (17%)
		leucine-rich repeat	548..571	CDD:275380	7/25 (28%)
		leucine-rich repeat	572..601	CDD:275380	5/43 (12%)
		leucine-rich repeat	602..624	CDD:275380	4/23 (17%)
		leucine-rich repeat	625..655	CDD:275380	7/43 (16%)
		leucine-rich repeat	656..680	CDD:275380	6/31 (19%)
		leucine-rich repeat	681..704	CDD:275380	5/22 (23%)
		leucine-rich repeat	705..728	CDD:275380	4/22 (18%)
		leucine-rich repeat	753..778	CDD:275380	8/49 (16%)
		PCC	757..>841	CDD:188093	19/114 (17%)
		TIR	894..1039	CDD:214587	38/145 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.780