Protein Alignment Toll-7 and Lrrn3

DIOPT Version :9

• Sequence 1: NP_523797.1
• Gene: Toll-7 / 37272
• FlyBaseID: FBgn0034476
• Length: 1446
• Species: Drosophila melanogaster
• Sequence 2: NP_001258637.1
• Gene: Lrrn3 / 16981
• MGIID: 106036
• Length: 707
• Species: Mus musculus
• Alignment Length: 423
• Identity: 113/423 - (26%)
• Similarity: 176/423 - (41%)
• Gaps: 85/423 - (20%)

  Fly   397 QILNLRNNSIGHIEDNAFLPLYNLHTLNLAENRLHTLDDKLFNGLYVLSKLTLNNNLISVVEPAV 461
            |||.|:.|:|..||.:...|: ||..|:|::                       |||.||....|
Mouse    72 QILLLQTNNIARIEHSTDFPV-NLTGLDLSQ-----------------------NNLSSVTNINV 112

  Fly   462 FKNCSDLKELDLSSNQLNEVP-RALQDLAMLRTLDLGENQIRTFDNQSFKNLHQLTGLRLIDNQI 525
            .| .|.|..:.|..|:|.|:| :.|..|:.|:.|.:..|.:.|....:|..||.|..|.|..|::
Mouse   113 QK-MSQLLSVYLEENKLTELPEKCLYGLSNLQELYVNHNLLSTISPGAFIGLHNLLRLHLNSNRL 176

  Fly   526 GNITVGMFQDLPRLSVLNLAKNRIQSIERGSFDKNFELEAIRLDRNFLADIN------GVFATLV 584
            ..|....|..||.|.:|.|..|.|..|:    |.||: ..::|....:|.||      ...|.|.
Mouse   177 QMINSQWFDALPNLEILMLGDNPIIRIK----DMNFQ-PLVKLRSLVIAGINLTEIPDDALAGLE 236

  Fly   585 SLLWLNLSENHLVWFDYAFIPS-------NLKWLDIHGNYIEAL--GNYYKLQEEIRVKTLDASH 640
            :|..::..:|.|     :.:|.       |||:||::.|.|..:  |::..:   :.:|.|..::
Mouse   237 NLESISFYDNRL-----SKVPQVALQKAVNLKFLDLNKNPINRIRRGDFSNM---LHLKELGINN 293

  Fly   641 -NRITEIGPMSIPNTIELLFI---NNNLIGNVQPNAFVDKANLARVDLYANQLSKLQLQQLRVAP 701
             ..:..|..:::.|..:|..|   ||..:..:.||||.....|..:.|..|.||.|....:...|
Mouse   294 MPELVSIDSLAVDNLPDLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNTNALSALYHGTIESLP 358

  Fly   702 VVAPKPLPEFYLGGNPFECDCTMDWLQRINNLTTRQHPRVMDMANIECV-MPHARGAAVR----- 760
                 .|.|..:..||..|||.:.|:.     ..:.:.|.|:..::.|| .|..:|..||
Mouse   359 -----NLKEISIHSNPIRCDCVIRWIN-----MNKTNIRFMEPDSLFCVDPPEFQGQNVRQVHFR 413

  Fly   761 -------PLSGLRPQDFL--CRYESHCFALCHC 784
                   ||  :.|:.|.  ...|:..:...||
Mouse   414 DMMEICLPL--IAPESFPSDLDVEADSYVSLHC 444

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Toll-7	NP_523797.1	LRR_8	135..201	CDD:290566
		leucine-rich repeat	136..159	CDD:275380
		leucine-rich repeat	160..190	CDD:275380
		LRR_8	189..259	CDD:290566
		leucine-rich repeat	191..214	CDD:275380
		leucine-rich repeat	215..248	CDD:275380
		LRR_RI	247..501	CDD:238064	32/104 (31%)
		LRR_8	247..308	CDD:290566
		leucine-rich repeat	249..273	CDD:275380
		leucine-rich repeat	274..297	CDD:275380
		LRR_8	297..356	CDD:290566
		leucine-rich repeat	298..321	CDD:275380
		leucine-rich repeat	322..345	CDD:275380
		LRR_8	345..406	CDD:290566	5/8 (63%)
		leucine-rich repeat	346..371	CDD:275380
		leucine-rich repeat	372..395	CDD:275380
		leucine-rich repeat	396..419	CDD:275380	9/21 (43%)
		LRR_8	419..478	CDD:290566	15/58 (26%)
		leucine-rich repeat	420..443	CDD:275380	3/22 (14%)
		leucine-rich repeat	444..467	CDD:275380	7/22 (32%)
		LRR_RI	466..622	CDD:238064	50/171 (29%)
		leucine-rich repeat	468..488	CDD:275380	7/20 (35%)
		LRR_8	491..549	CDD:290566	19/57 (33%)
		leucine-rich repeat	491..514	CDD:275380	6/22 (27%)
		leucine-rich repeat	515..536	CDD:275380	6/20 (30%)
		leucine-rich repeat	539..562	CDD:275380	8/22 (36%)
		leucine-rich repeat	563..585	CDD:275380	6/27 (22%)
		leucine-rich repeat	586..626	CDD:275380	12/48 (25%)
		leucine-rich repeat	627..653	CDD:275380	3/26 (12%)
		LRRCT	716..772	CDD:214507	18/70 (26%)
		LRRNT	796..830	CDD:214470
		leucine-rich repeat	812..829	CDD:275380
		leucine-rich repeat	833..854	CDD:275380
		LRR_8	853..913	CDD:290566
		leucine-rich repeat	855..878	CDD:275380
		LRR_4	878..918	CDD:289563
		leucine-rich repeat	879..902	CDD:275380
		leucine-rich repeat	903..926	CDD:275380
		leucine-rich repeat	927..953	CDD:275380
		TIR	1098..1235	CDD:214587
Lrrn3	NP_001258637.1	LRRNT	28..72	CDD:214470	113/423 (27%)
		LRR 1	70..91		8/18 (44%)
		leucine-rich repeat	72..93	CDD:275380	9/21 (43%)
		LRR_8	93..152	CDD:290566	23/82 (28%)
		LRR 2	93..114		10/43 (23%)
		leucine-rich repeat	94..117	CDD:275380	10/46 (22%)
		LRR 3	117..138		7/20 (35%)
		leucine-rich repeat	118..141	CDD:275380	8/22 (36%)
		LRR	139..160	CDD:197688	5/20 (25%)
		LRR 4	141..162		5/20 (25%)
		leucine-rich repeat	142..165	CDD:275380	6/22 (27%)
		LRR 5	165..186		6/20 (30%)
		leucine-rich repeat	166..189	CDD:275380	7/22 (32%)
		LRR_8	173..221	CDD:290566	15/52 (29%)
		LRR 6	189..210		9/25 (36%)
		leucine-rich repeat	190..213	CDD:275380	9/27 (33%)
		LRR_8	213..272	CDD:290566	16/63 (25%)
		LRR 7	213..234		4/20 (20%)
		leucine-rich repeat	214..237	CDD:275380	6/22 (27%)
		LRR 8	237..258		4/25 (16%)
		leucine-rich repeat	238..261	CDD:275380	4/27 (15%)
		LRR 9	261..282		8/20 (40%)
		leucine-rich repeat	262..285	CDD:275380	7/25 (28%)
		LRR 10	285..304		3/18 (17%)
		leucine-rich repeat	286..310	CDD:275380	4/23 (17%)
		LRR 11	310..332		8/21 (38%)
		LRR_8	311..370	CDD:290566	18/63 (29%)
		leucine-rich repeat	311..333	CDD:275380	8/21 (38%)
		LRR 12	335..358		6/22 (27%)
		leucine-rich repeat	336..359	CDD:275380	7/27 (26%)
		LRRCT	368..419	CDD:214507	14/55 (25%)
		I-set	429..513	CDD:254352	3/16 (19%)
		Ig	440..513	CDD:299845	2/5 (40%)
		fn3	526..593	CDD:278470

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010