DRSC/TRiP Functional Genomics Resources

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Protein Alignment Toll-7 and Tlr3

DIOPT Version :9

Sequence 1:NP_523797.1 Gene:Toll-7 / 37272 FlyBaseID:FBgn0034476 Length:1446 Species:Drosophila melanogaster
Sequence 2:NP_001344245.1 Gene:Tlr3 / 142980 MGIID:2156367 Length:905 Species:Mus musculus


Alignment Length:1151 Identity:245/1151 - (21%)
Similarity:415/1151 - (36%) Gaps:342/1151 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   184 SLGGLKQLTDLDLGDNN---------------LRQLPSGFLCPVGNLQVLNLTRNRIRTAEQMGF 233
            |.|||..|..|.:...|               |..:|...   ..|:.|||||.|::|......|
Mouse    11 SFGGLLSLWILLVSSTNQCTVRYNVADCSHLKLTHIPDDL---PSNITVLNLTHNQLRRLPPTNF 72

  Fly   234 ADMNCGAGSGSAGSELQVLDASHNELRSISESWGISRLRRLQHLNLAYNNLSELSGEALAGLASL 298
                      :..|:|.:|||..|.:..: |......|..|:.|||.:|.||::|.:......:|
Mouse    73 ----------TRYSQLAILDAGFNSISKL-EPELCQILPLLKVLNLQHNELSQISDQTFVFCTNL 126

  Fly   299 RIVNLSNNHLETLPEGLFAGSKELREIHLQQNELYELPKGLFHRLEQLLVVDLSGNQLTSNHVDN 363
            ..::|.:|.:..:....|...|.|.::.|..|.|.....|...:||.|..:.|:.|::.:...:.
Mouse   127 TELDLMSNSIHKIKSNPFKNQKNLIKLDLSHNGLSSTKLGTGVQLENLQELLLAKNKILALRSEE 191

  Fly   364 TTFAGLIRLIVLNLAHNALTRID---YRTFKELYFLQILNLRNNSIGHIEDNAFLPLYN--LHTL 423
            ..|.|...|..|:|:.|.|....   ::|..:|:.|.:.|.:.|.  |:.:.....|.|  :..|
Mouse   192 LEFLGNSSLRKLDLSSNPLKEFSPGCFQTIGKLFALLLNNAQLNP--HLTEKLCWELSNTSIQNL 254

  Fly   424 NLAENRLHTLDDKLFNGLYVLSKLTLNNNLISVVEPAVFKNCSDLKELDLSSNQLNEVPR-ALQD 487
            :||.|:|....:..|:||                      ..::|.:||||.|.|::|.. :...
Mouse   255 SLANNQLLATSESTFSGL----------------------KWTNLTQLDLSYNNLHDVGNGSFSY 297

  Fly   488 LAMLRTLDLGENQIRTFDNQSF---KNLHQLTGLRLIDNQI------GNITVGMFQDLPRLSVLN 543
            |..||.|.|..|.|:....:||   .||..|:..|....|.      .||....||.|..|..||
Mouse   298 LPSLRYLSLEYNNIQRLSPRSFYGLSNLRYLSLKRAFTKQSVSLASHPNIDDFSFQWLKYLEYLN 362

  Fly   544 LAKNRIQSIERGSFDKNFELEAIRLDRNFLA---DINGVFATLV--SLLWLNLSENHL------- 596
            :..|.|.|.:..:|.....|:.:.|.:.|.:   ..|..|.:|.  .||.|||::||:       
Mouse   363 MDDNNIPSTKSNTFTGLVSLKYLSLSKTFTSLQTLTNETFVSLAHSPLLTLNLTKNHISKIANGT 427

  Fly   597 -VWFDYAFIPSNLKWLDIHGNYIE---------ALGNYYKLQEEIRVKTLDASHNRITEIGPMS- 650
             .|.      ..|:.||:..|.||         .|.|.:::.         .|:|:..::...| 
Mouse   428 FSWL------GQLRILDLGLNEIEQKLSGQEWRGLRNIFEIY---------LSYNKYLQLSTSSF 477

  Fly   651 --IPNTIELLFINNNLIGNV--QPNAFVDKANLARVDLYANQLSKLQLQQLRVAPVVAPKPLPEF 711
              :| :::.|.:....:.||  .|:.|....||..:||..|.::.:                   
Mouse   478 ALVP-SLQRLMLRRVALKNVDISPSPFRPLRNLTILDLSNNNIANI------------------- 522

  Fly   712 YLGGNPFECDCTMDWLQRINNLTTR--QH---PRVMDMANIECVMPHARGAAVRPLSGLRPQDFL 771
                       ..|.|:.:.||...  ||   .|:...||        .|..|..|.||      
Mouse   523 -----------NEDLLEGLENLEILDFQHNNLARLWKRAN--------PGGPVNFLKGL------ 562

  Fly   772 CRYESHCFALCHCCDFDACDCEMTCPSNCTCYHDQIWSTNVVDCGGQQTTELPRRVPMDSSVVYL 836
                ||    .|..:.:                     :|.:|       |:|            
Mouse   563 ----SH----LHILNLE---------------------SNGLD-------EIP------------ 579

  Fly   837 DGNNFPVLKNHAFIGRKNLRALYVNGSQVAAIQNRTFASLASLQLLHLADNKLRTLHGYEFEQLS 901
                         :|                    .|.:|..|:.::|..|.|..|..:.|:..:
Mouse   580 -------------VG--------------------VFKNLFELKSINLGLNNLNKLEPFIFDDQT 611

  Fly   902 ALRELYLQNNQLTTIENATLAPLAALELIRIDGNRLVTLPIWQMHATHFGTRLKSISLGRNQWSC 966
            :||.|.||.|.:|::|.....|                 |.         ..|.|:.:..|.:.|
Mouse   612 SLRSLNLQKNLITSVEKDVFGP-----------------PF---------QNLNSLDMRFNPFDC 650

  Fly   967 RCQFLQALTSYVADNALIVQDAQDIY-CMAASSGTG-SAALEDSSSNSGSLEKRELDFNATGAAC 1029
            .|:.:....:::......:.:....| |.......| ...|.|:||                  |
Mouse   651 TCESISWFVNWINQTHTNISELSTHYLCNTPHHYYGFPLKLFDTSS------------------C 697

  Fly  1030 TDYYSGGSMLQHGIPESYIPLLAAALALLFLLVVIAMVFAFRESLRIWLFAHYGV-RVFG----- 1088
            .|          ..|...:.:::.::.|:|:|||:.:..   |..||..:.:..| |:.|     
Mouse   698 KD----------SAPFELLFIISTSMLLVFILVVLLIHI---EGWRISFYWNVSVHRILGFKEID 749

  Fly  1089 PRCEESEKLYDAVLLHSAKDSEFVCQHLAAQLETGRPPLRVCLQHRDLAHDATHYQ-LLEATRVS 1152
            .:.|:.|  |.|.::|:.||.::|.:|. :.:|.....|:.||:.||........: ::.:.:.|
Mouse   750 TQAEQFE--YTAYIIHAHKDRDWVWEHF-SPMEEQDQSLKFCLEERDFEAGVLGLEAIVNSIKRS 811

  Fly  1153 RRVVILLTRNFLQTEWARCELRRSVHDALRGRPQKLVIIEEPEVAFEAESDIELLPYLKTSAVHR 1217
            |:::.::|.:.|:....|   |..||.|:             :.|.|...|..:|.:|:....: 
Mouse   812 RKIIFVITHHLLKDPLCR---RFKVHHAV-------------QQAIEQNLDSIILIFLQNIPDY- 859

  Fly  1218 IRRSDRHFWEKLRYALPVDYPTFRGN---NYTLELDHHN--HERVK 1258
                      ||.:||.:....|:.:   |:.::.:..|  |.:::
Mouse   860 ----------KLNHALCLRRGMFKSHCILNWPVQKERINAFHHKLQ 895

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-7NP_523797.1 LRR_8 135..201 CDD:290566 7/31 (23%)
leucine-rich repeat 136..159 CDD:275380
leucine-rich repeat 160..190 CDD:275380 4/5 (80%)
LRR_8 189..259 CDD:290566 20/84 (24%)
leucine-rich repeat 191..214 CDD:275380 5/37 (14%)
leucine-rich repeat 215..248 CDD:275380 8/32 (25%)
LRR_RI 247..501 CDD:238064 68/259 (26%)
LRR_8 247..308 CDD:290566 19/60 (32%)
leucine-rich repeat 249..273 CDD:275380 7/23 (30%)
leucine-rich repeat 274..297 CDD:275380 8/22 (36%)
LRR_8 297..356 CDD:290566 15/58 (26%)
leucine-rich repeat 298..321 CDD:275380 4/22 (18%)
leucine-rich repeat 322..345 CDD:275380 6/22 (27%)
LRR_8 345..406 CDD:290566 15/63 (24%)
leucine-rich repeat 346..371 CDD:275380 5/24 (21%)
leucine-rich repeat 372..395 CDD:275380 7/25 (28%)
leucine-rich repeat 396..419 CDD:275380 5/22 (23%)
LRR_8 419..478 CDD:290566 15/60 (25%)
leucine-rich repeat 420..443 CDD:275380 8/22 (36%)
leucine-rich repeat 444..467 CDD:275380 0/22 (0%)
LRR_RI 466..622 CDD:238064 54/187 (29%)
leucine-rich repeat 468..488 CDD:275380 8/20 (40%)
LRR_8 491..549 CDD:290566 22/66 (33%)
leucine-rich repeat 491..514 CDD:275380 10/25 (40%)
leucine-rich repeat 515..536 CDD:275380 7/26 (27%)
leucine-rich repeat 539..562 CDD:275380 7/22 (32%)
leucine-rich repeat 563..585 CDD:275380 6/26 (23%)
leucine-rich repeat 586..626 CDD:275380 16/56 (29%)
leucine-rich repeat 627..653 CDD:275380 3/28 (11%)
LRRCT 716..772 CDD:214507 14/60 (23%)
LRRNT 796..830 CDD:214470 4/33 (12%)
leucine-rich repeat 812..829 CDD:275380 3/16 (19%)
leucine-rich repeat 833..854 CDD:275380 1/20 (5%)
LRR_8 853..913 CDD:290566 14/59 (24%)
leucine-rich repeat 855..878 CDD:275380 2/22 (9%)
LRR_4 878..918 CDD:289563 13/39 (33%)
leucine-rich repeat 879..902 CDD:275380 6/22 (27%)
leucine-rich repeat 903..926 CDD:275380 9/22 (41%)
leucine-rich repeat 927..953 CDD:275380 1/25 (4%)
TIR 1098..1235 CDD:214587 31/137 (23%)
Tlr3NP_001344245.1 leucine-rich repeat 37..53 CDD:275380 2/18 (11%)
LRR 1 53..74 9/30 (30%)
leucine-rich repeat 54..77 CDD:275380 8/32 (25%)
PLN00113 70..>543 CDD:215061 131/553 (24%)
LRR 2 77..98 6/21 (29%)
leucine-rich repeat 78..101 CDD:275380 7/23 (30%)
LRR 3 101..122 8/20 (40%)
leucine-rich repeat 102..125 CDD:275380 8/22 (36%)
LRR 4 125..146 4/20 (20%)
leucine-rich repeat 126..149 CDD:275380 4/22 (18%)
LRR 5 149..170 5/20 (25%)
leucine-rich repeat 150..199 CDD:275380 12/48 (25%)
LRR 6 173..196 4/22 (18%)
LRR 7 199..220 5/20 (25%)
leucine-rich repeat 200..250 CDD:275380 13/51 (25%)
LRR 8 250..271 6/20 (30%)
leucine-rich repeat 251..276 CDD:275380 8/46 (17%)
LRR 9 276..297 8/20 (40%)
leucine-rich repeat 277..300 CDD:275380 9/22 (41%)
LRR 10 300..321 8/20 (40%)
leucine-rich repeat 301..324 CDD:275380 8/22 (36%)
LRR 11 324..345 5/20 (25%)
leucine-rich repeat 325..381 CDD:275380 16/55 (29%)
LRR 12 357..378 7/20 (35%)
LRR 13 381..401 4/19 (21%)
leucine-rich repeat 382..433 CDD:275380 14/56 (25%)
LRR 14 409..430 7/20 (35%)
LRR 15 433..454 6/20 (30%)
leucine-rich repeat 434..458 CDD:275380 7/23 (30%)
LRR 16 458..479 4/29 (14%)
leucine-rich repeat 459..482 CDD:275380 4/32 (13%)
LRR 17 482..502 4/19 (21%)
leucine-rich repeat 483..508 CDD:275380 5/24 (21%)
PPP1R42 503..>649 CDD:411060 49/296 (17%)
LRR 18 508..529 7/50 (14%)
leucine-rich repeat 509..532 CDD:275380 6/52 (12%)
LRR 19 532..553 7/28 (25%)
leucine-rich repeat 533..564 CDD:275380 11/48 (23%)
LRR 20 564..585 8/97 (8%)
leucine-rich repeat 565..586 CDD:275380 7/93 (8%)
LRR 21 588..609 6/20 (30%)
leucine-rich repeat 589..610 CDD:275378 6/20 (30%)
LRR 22 612..633 8/20 (40%)
leucine-rich repeat 613..637 CDD:275380 10/49 (20%)
LRRCT 646..698 CDD:214507 10/69 (14%)
Tlr3_TMD 699..731 CDD:407816 8/44 (18%)
TIR 756..901 CDD:214587 36/170 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4641
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
32.870

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