DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-7 and LRRC15

DIOPT Version :9

Sequence 1:	NP_523797.1	Gene:	Toll-7 / 37272	FlyBaseID:	FBgn0034476	Length:	1446	Species:	Drosophila melanogaster
Sequence 2:	NP_001128529.2	Gene:	LRRC15 / 131578	HGNCID:	20818	Length:	587	Species:	Homo sapiens

Alignment Length:	350	Identity:	122/350 - (34%)
Similarity:	171/350 - (48%)	Gaps:	8/350 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   249 LQVLDASHNELRSISESWGISRLRRLQHLNLAYNNLSELSGEALAGLASLRIVNLSNNHLETLPE 313
            ||:|:....||.. |....||.|..|:   :..|.||.::..|...|.|||.::|:||.|:.||.
Human    64 LQILNTHITELNE-SPFLNISALIALR---IEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPI 124

  Fly   314 GLFAGSKELREIHLQQNELYELPKGLFHRLEQLLVVDLSGNQLTSNHVDNTTFAGLIRLIVLNLA 378
            |||.|...|..:.|..|:|.::....|.:...|..:.|.||.|  .::.:..|..|:.|..|||.
Human   125 GLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHL--EYIPDGAFDHLVGLTKLNLG 187

  Fly   379 HNALTRIDYRTFKELYFLQILNLRNNSIGHIEDNAFLPLYNLHTLNLAENRLHTLDDKLFNGLYV 443
            .|:||.|..|.|:.|..||:|.|..|.:..|....|..|.||..|.|.:|::..|...||:..:.
Human   188 KNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHN 252

  Fly   444 LSKLTLNNNLISVVEPAVFKNCSDLKELDLSSNQLNEV-PRALQDLAMLRTLDLGENQIRTFDNQ 507
            |.:|.|:||.||.:.|:||.....|..|.|..|.|.|: |.....:..||.|.|.:|.|.:..:.
Human   253 LQRLYLSNNHISQLPPSVFMQLPQLNRLTLFGNSLKELSPGIFGPMPNLRELWLYDNHISSLPDN 317

  Fly   508 SFKNLHQLTGLRLIDNQIGNITVGMFQDLPRLSVLNLAKNRIQSIERGSFDKNFELEAIRLDRNF 572
            .|.||.||..|.|..|||..|:.|.|..|..|..|:|..|.:|.::...|.....|:.|.|..|.
Human   318 VFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNR 382

  Fly   573 LADING-VFATLVSLLWLNLSENHL 596
            |..:.| :||.:..|:.:.|..|.|
Human   383 LRQLPGNIFANVNGLMAIQLQNNQL 407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-7	NP_523797.1	LRR_8	135..201	CDD:290566
		leucine-rich repeat	136..159	CDD:275380
		leucine-rich repeat	160..190	CDD:275380
		LRR_8	189..259	CDD:290566	3/9 (33%)
		leucine-rich repeat	191..214	CDD:275380
		leucine-rich repeat	215..248	CDD:275380
		LRR_RI	247..501	CDD:238064	89/252 (35%)
		LRR_8	247..308	CDD:290566	21/58 (36%)
		leucine-rich repeat	249..273	CDD:275380	9/23 (39%)
		leucine-rich repeat	274..297	CDD:275380	6/22 (27%)
		LRR_8	297..356	CDD:290566	22/58 (38%)
		leucine-rich repeat	298..321	CDD:275380	12/22 (55%)
		leucine-rich repeat	322..345	CDD:275380	5/22 (23%)
		LRR_8	345..406	CDD:290566	23/60 (38%)
		leucine-rich repeat	346..371	CDD:275380	7/24 (29%)
		leucine-rich repeat	372..395	CDD:275380	11/22 (50%)
		leucine-rich repeat	396..419	CDD:275380	8/22 (36%)
		LRR_8	419..478	CDD:290566	22/58 (38%)
		leucine-rich repeat	420..443	CDD:275380	7/22 (32%)
		leucine-rich repeat	444..467	CDD:275380	10/22 (45%)
		LRR_RI	466..622	CDD:238064	44/132 (33%)
		leucine-rich repeat	468..488	CDD:275380	7/20 (35%)
		LRR_8	491..549	CDD:290566	24/57 (42%)
		leucine-rich repeat	491..514	CDD:275380	9/22 (41%)
		leucine-rich repeat	515..536	CDD:275380	9/20 (45%)
		leucine-rich repeat	539..562	CDD:275380	6/22 (27%)
		leucine-rich repeat	563..585	CDD:275380	8/22 (36%)
		leucine-rich repeat	586..626	CDD:275380	3/10 (30%)
		leucine-rich repeat	627..653	CDD:275380
		LRRCT	716..772	CDD:214507
		LRRNT	796..830	CDD:214470
		leucine-rich repeat	812..829	CDD:275380
		leucine-rich repeat	833..854	CDD:275380
		LRR_8	853..913	CDD:290566
		leucine-rich repeat	855..878	CDD:275380
		LRR_4	878..918	CDD:289563
		leucine-rich repeat	879..902	CDD:275380
		leucine-rich repeat	903..926	CDD:275380
		leucine-rich repeat	927..953	CDD:275380
		TIR	1098..1235	CDD:214587
LRRC15	NP_001128529.2	LRR_8	60..119	CDD:290566	21/58 (36%)
		LRR_RI	63..309	CDD:238064	88/250 (35%)
		LRR_8	88..167	CDD:290566	28/81 (35%)
		leucine-rich repeat	88..108	CDD:275380	6/22 (27%)
		leucine-rich repeat	109..156	CDD:275380	17/46 (37%)
		leucine-rich repeat	157..180	CDD:275380	7/24 (29%)
		LRR_8	180..239	CDD:290566	24/58 (41%)
		leucine-rich repeat	181..204	CDD:275380	11/22 (50%)
		leucine-rich repeat	205..228	CDD:275380	8/22 (36%)
		LRR_8	228..287	CDD:290566	22/58 (38%)
		leucine-rich repeat	229..252	CDD:275380	7/22 (32%)
		leucine-rich repeat	253..276	CDD:275380	10/22 (45%)
		leucine-rich repeat	277..300	CDD:275380	7/22 (32%)
		LRR_8	299..359	CDD:290566	24/59 (41%)
		LRR_4	299..340	CDD:289563	17/40 (43%)
		leucine-rich repeat	301..324	CDD:275380	9/22 (41%)
		LRR_4	324..364	CDD:289563	16/39 (41%)
		leucine-rich repeat	325..348	CDD:275380	10/22 (45%)
		leucine-rich repeat	349..370	CDD:275380	6/20 (30%)
		LRR_8	372..430	CDD:290566	11/35 (31%)
		leucine-rich repeat	373..393	CDD:275380	7/19 (37%)
		leucine-rich repeat	397..418	CDD:275380	3/10 (30%)
		TPKR_C2	429..>468	CDD:301599
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8435
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.010