DRSC/TRiP Functional Genomics Resources

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Protein Alignment Toll-7 and ELFN2

DIOPT Version :9

Sequence 1:NP_523797.1 Gene:Toll-7 / 37272 FlyBaseID:FBgn0034476 Length:1446 Species:Drosophila melanogaster
Sequence 2:NP_443138.2 Gene:ELFN2 / 114794 HGNCID:29396 Length:820 Species:Homo sapiens


Alignment Length:194 Identity:59/194 - (30%)
Similarity:81/194 - (41%) Gaps:34/194 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly   360 HVDNTTFAGLIRLIVLNLAHNALTRIDYRTFKELYFLQILNLRNNSIGHIEDNAFLPLYNLHTLN 424
            |:::|...       |.|..|.|..:.|.:......|..|||..|.|.:|||.|||...:|..|.
Human    52 HINSTVHD-------LRLNENKLKAVLYSSLNRFGNLTDLNLTKNEISYIEDGAFLGQSSLQVLQ 109

  Fly   425 LAENRLHTLDDKLFNGLYVLSKLTLNNNLISVVEPAVFKNCSDLKELDLSSNQLNEVPRALQDLA 489
            |..|:|..|.:.:..|:..|..|.:.:|||.||.|..|..|..|..:|||||:|:.:        
Human   110 LGYNKLSNLTEGMLRGMSRLQFLFVQHNLIEVVTPTAFSECPSLISIDLSSNRLSRL-------- 166

  Fly   490 MLRTLDLGENQIRTFDNQSFKNLHQLTGLRLIDNQIGNITVGMFQDLPRLSVL-NLAKN--RIQ 550
                           |..:|.:|..|....|..|.. |....:|..|..|.|. |:.||  |:|
Human   167 ---------------DGATFASLASLMVCELAGNPF-NCECDLFGFLAWLVVFNNVTKNYDRLQ 214

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-7NP_523797.1 LRR_8 135..201 CDD:290566
leucine-rich repeat 136..159 CDD:275380
leucine-rich repeat 160..190 CDD:275380
LRR_8 189..259 CDD:290566
leucine-rich repeat 191..214 CDD:275380
leucine-rich repeat 215..248 CDD:275380
LRR_RI 247..501 CDD:238064 43/140 (31%)
LRR_8 247..308 CDD:290566
leucine-rich repeat 249..273 CDD:275380
leucine-rich repeat 274..297 CDD:275380
LRR_8 297..356 CDD:290566
leucine-rich repeat 298..321 CDD:275380
leucine-rich repeat 322..345 CDD:275380
LRR_8 345..406 CDD:290566 12/45 (27%)
leucine-rich repeat 346..371 CDD:275380 2/10 (20%)
leucine-rich repeat 372..395 CDD:275380 5/22 (23%)
leucine-rich repeat 396..419 CDD:275380 12/22 (55%)
LRR_8 419..478 CDD:290566 23/58 (40%)
leucine-rich repeat 420..443 CDD:275380 7/22 (32%)
leucine-rich repeat 444..467 CDD:275380 10/22 (45%)
LRR_RI 466..622 CDD:238064 23/88 (26%)
leucine-rich repeat 468..488 CDD:275380 7/19 (37%)
LRR_8 491..549 CDD:290566 14/60 (23%)
leucine-rich repeat 491..514 CDD:275380 3/22 (14%)
leucine-rich repeat 515..536 CDD:275380 5/20 (25%)
leucine-rich repeat 539..562 CDD:275380 7/15 (47%)
leucine-rich repeat 563..585 CDD:275380
leucine-rich repeat 586..626 CDD:275380
leucine-rich repeat 627..653 CDD:275380
LRRCT 716..772 CDD:214507
LRRNT 796..830 CDD:214470
leucine-rich repeat 812..829 CDD:275380
leucine-rich repeat 833..854 CDD:275380
LRR_8 853..913 CDD:290566
leucine-rich repeat 855..878 CDD:275380
LRR_4 878..918 CDD:289563
leucine-rich repeat 879..902 CDD:275380
leucine-rich repeat 903..926 CDD:275380
leucine-rich repeat 927..953 CDD:275380
TIR 1098..1235 CDD:214587
ELFN2NP_443138.2 LRR 1 56..77 6/27 (22%)
leucine-rich repeat 60..80 CDD:275378 5/19 (26%)
LRR_8 80..139 CDD:316378 22/58 (38%)
LRR 2 80..101 11/20 (55%)
leucine-rich repeat 81..104 CDD:275378 12/22 (55%)
LRR 3 104..125 6/20 (30%)
leucine-rich repeat 105..128 CDD:275378 7/22 (32%)
LRR_8 127..187 CDD:316378 23/82 (28%)
LRR 4 128..149 9/20 (45%)
leucine-rich repeat 129..152 CDD:275378 10/22 (45%)
LRR 5 152..173 9/43 (21%)
leucine-rich repeat 153..166 CDD:275378 7/12 (58%)
PCC 157..>227 CDD:188093 22/82 (27%)
leucine-rich repeat 200..226 CDD:275380 7/15 (47%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 250..294
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 508..527
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 589..612
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 654..677
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24373
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.100

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