DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Toll-7 and TLR6

DIOPT Version :10

Sequence 1:NP_523797.1 Gene:Toll-7 / 37272 FlyBaseID:FBgn0034476 Length:1446 Species:Drosophila melanogaster
Sequence 2:NP_006059.2 Gene:TLR6 / 10333 HGNCID:16711 Length:796 Species:Homo sapiens


Alignment Length:907 Identity:195/907 - (21%)
Similarity:331/907 - (36%) Gaps:290/907 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   194 LDLGDNNLRQLPSGFLCPVGNLQVLNLTRNRIRTAEQMGFADMNCGAGSGSAGSELQVLDASHNE 258
            ||:..|.:.:|....:..:..|.||.|:.|||:..:...|          ....:|:.||.|||:
Human    57 LDMSQNYIAELQVSDMSFLSELTVLRLSHNRIQLLDLSVF----------KFNQDLEYLDLSHNQ 111

  Fly   259 LRSISESWGISRLRRLQHLNLAYN------------NLSELSGEALAGL---------------- 295
            |:.||    ...:...:||:|::|            |||:|:...|:.:                
Human   112 LQKIS----CHPIVSFRHLDLSFNDFKALPICKEFGNLSQLNFLGLSAMKLQKLDLLPIAHLHLS 172

  Fly   296 ----------------ASLRIVNLSNNHLETLPEGLFA----------GSKELREIHLQQNE--- 331
                            .||:|:|....||...|..|||          |..:|..|.|..:.   
Human   173 YILLDLRNYYIKENETESLQILNAKTLHLVFHPTSLFAIQVNISVNTLGCLQLTNIKLNDDNCQV 237

  Fly   332 ----LYELPKGLFHRLEQLLVVDLSGNQLTSNHVDNTTFAGLIRLI---------VLNLAHNALT 383
                |.||.:|     ..||       ..|.||:: ||:..|:|:.         .||:.:  ||
Human   238 FIKFLSELTRG-----STLL-------NFTLNHIE-TTWKCLVRVFQFLWPKPVEYLNIYN--LT 287

  Fly   384 RIDYRTFKELYFLQILNLRNNSIGHIEDNAFL----PLYNLHT-LNLAENRLHTLDDKLFNGLYV 443
            .|: ...:|.:......|:..:|.||.:..||    .||.:.: :|:   .:.|:.|..|  :::
Human   288 IIE-SIREEDFTYSKTTLKALTIEHITNQVFLFSQTALYTVFSEMNI---MMLTISDTPF--IHM 346

  Fly   444 L-----SKLTLNNNLISVVEPAVFKNCSDLKELDLSSNQLNEVPRALQDLAMLRTLDLGENQIRT 503
            |     |.....|...:|...::|:.||.|.:|:                    ||.|.:|.::.
Human   347 LCPHAPSTFKFLNFTQNVFTDSIFEKCSTLVKLE--------------------TLILQKNGLKD 391

  Fly   504 FDNQSFKNLHQLTGLRLIDNQIGNITVGMFQDLPRLSVLNLAKNRIQSIERGSFDKNFELEAIRL 568
            .    ||     .||             |.:|:|.|.:|:::.|   |:|.|...:|        
Human   392 L----FK-----VGL-------------MTKDMPSLEILDVSWN---SLESGRHKEN-------- 423

  Fly   569 DRNFLADINGVFATLV-SLLWLNLSENHLVWFDYAFIPSNLKWLDIHGNYIEAL-GNYYKLQEEI 631
                        .|.| |::.||||.|.|....:..:|..:|.||:|.|.|::: ....||:   
Human   424 ------------CTWVESIVVLNLSSNMLTDSVFRCLPPRIKVLDLHSNKIKSVPKQVVKLE--- 473

  Fly   632 RVKTLDASHNRITEIGPMSIPNTIELLFINNNLIGNVQPNAFVDKANLARVDLYANQLSKLQLQQ 696
            .::.|:.:.|.:|::......:::.:|.|::|.:.:  |:|          |.:.:      .|:
Human   474 ALQELNVAFNSLTDLPGCGSFSSLSVLIIDHNSVSH--PSA----------DFFQS------CQK 520

  Fly   697 LRVAPVVAPKPLPEFYLGGNPFECDCTM-DWLQRINNLTTRQHPRVMDMANIECVMPHA-RGAAV 759
            :|           ....|.|||:|.|.: ::::.|:.:::.......|  :.:|..|.: ||:  
Human   521 MR-----------SIKAGDNPFQCTCELREFVKNIDQVSSEVLEGWPD--SYKCDYPESYRGS-- 570

  Fly   760 RPLSGLRPQDFLCRYESHCFALCHCCDFDACDCEMTCPSNCTCYHDQIWSTNVVDCGGQQTTELP 824
             ||......:..|    :...|............:|..|.| .|.|..|...:| |...||....
Human   571 -PLKDFHMSELSC----NITLLIVTIGATMLVLAVTVTSLC-IYLDLPWYLRMV-CQWTQTRRRA 628

  Fly   825 RRVPMDSSVVYLDGNNFPVLKNHAFIGRKNLRALYVNGSQVAAIQNRTFASLASLQLLHLADNKL 889
            |.:|::.    |..|    |:.||||......:.:|....|..::..      .:|:        
Human   629 RNIPLEE----LQRN----LQFHAFISYSEHDSAWVKSELVPYLEKE------DIQI-------- 671

  Fly   890 RTLHGYEFEQLSALRELYLQNNQLTTIENA-----TLAP-------------LAALELIRIDGNR 936
             .||...|....::.|     |.:..||.:     .|:|             .|...|.....|.
Human   672 -CLHERNFVPGKSIVE-----NIINCIEKSYKSIFVLSPNFVQSEWCHYELYFAHHNLFHEGSNN 730

  Fly   937 LVTL---PIWQMHATHFGTRLKSISLGRN--QW------------SCRCQFLQALTSYVADN 981
            |:.:   ||.|....:...:||::...|.  ||            :.|..|...||....:|
Human   731 LILILLEPIPQNSIPNKYHKLKALMTQRTYLQWPKEKSKRGLFWANIRAAFNMKLTLVTENN 792

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-7NP_523797.1 LRR 45..473 CDD:443914 84/358 (23%)
leucine-rich repeat 136..159 CDD:275380
leucine-rich repeat 160..190 CDD:275380
leucine-rich repeat 191..214 CDD:275380 4/19 (21%)
leucine-rich repeat 215..248 CDD:275380 8/32 (25%)
leucine-rich repeat 249..273 CDD:275380 9/23 (39%)
leucine-rich repeat 274..297 CDD:275380 9/66 (14%)
leucine-rich repeat 298..321 CDD:275380 10/32 (31%)
leucine-rich repeat 322..345 CDD:275380 7/29 (24%)
leucine-rich repeat 346..371 CDD:275380 8/24 (33%)
LRR 369..>675 CDD:443914 73/326 (22%)
leucine-rich repeat 372..395 CDD:275380 6/31 (19%)
leucine-rich repeat 396..419 CDD:275380 7/26 (27%)
leucine-rich repeat 420..443 CDD:275380 4/23 (17%)
leucine-rich repeat 444..467 CDD:275380 6/27 (22%)
leucine-rich repeat 468..488 CDD:275380 2/19 (11%)
leucine-rich repeat 491..514 CDD:275380 6/22 (27%)
leucine-rich repeat 515..536 CDD:275380 3/20 (15%)
leucine-rich repeat 539..562 CDD:275380 7/22 (32%)
leucine-rich repeat 563..585 CDD:275380 2/22 (9%)
leucine-rich repeat 586..626 CDD:275380 13/40 (33%)
leucine-rich repeat 627..653 CDD:275380 4/25 (16%)
LRRCT 716..772 CDD:214507 13/57 (23%)
LRR <812..>963 CDD:443914 35/173 (20%)
leucine-rich repeat 812..829 CDD:275380 5/16 (31%)
leucine-rich repeat 833..854 CDD:275380 7/20 (35%)
leucine-rich repeat 855..878 CDD:275380 2/22 (9%)
leucine-rich repeat 879..902 CDD:275380 4/22 (18%)
leucine-rich repeat 903..926 CDD:275380 6/40 (15%)
leucine-rich repeat 927..953 CDD:275380 6/28 (21%)
TIR 1098..1235 CDD:214587
TLR6NP_006059.2 leucine-rich repeat 36..53 CDD:275380
leucine-rich repeat 54..77 CDD:275378 4/19 (21%)
LRR 1 54..77 4/19 (21%)
LRR <55..327 CDD:443914 71/299 (24%)
leucine-rich repeat 78..101 CDD:275378 8/32 (25%)
LRR 2 78..101 8/32 (25%)
leucine-rich repeat 102..122 CDD:275378 9/23 (39%)
LRR 3 102..122 9/23 (39%)
leucine-rich repeat 123..147 CDD:275378 6/23 (26%)
LRR 4 123..147 6/23 (26%)
LRR 5 148..168 2/19 (11%)
leucine-rich repeat 148..161 CDD:275378 2/12 (17%)
LRR 6 169..196 3/26 (12%)
leucine-rich repeat 174..196 CDD:275380 3/21 (14%)
LRR 7 197..219 6/21 (29%)
LRR 8 220..250 8/34 (24%)
LRR 249..>531 CDD:443914 85/394 (22%)
LRR 9 251..277 9/33 (27%)
LRR 10 278..303 6/27 (22%)
LRR 11 304..330 8/25 (32%)
LRR 12 331..354 5/27 (19%)
LRR 13 355..378 6/22 (27%)
leucine-rich repeat 379..404 CDD:275380 11/66 (17%)
LRR 14 379..404 11/66 (17%)
leucine-rich repeat 405..429 CDD:275380 9/46 (20%)
LRR 15 405..429 9/46 (20%)
leucine-rich repeat 430..451 CDD:275380 7/20 (35%)
LRR 16 430..450 6/19 (32%)
LRR 17 451..474 8/25 (32%)
leucine-rich repeat 452..474 CDD:275380 8/24 (33%)
leucine-rich repeat 475..497 CDD:275380 3/21 (14%)
LRR 18 475..496 3/20 (15%)
LRR 19 497..520 6/40 (15%)
leucine-rich repeat 499..520 CDD:275380 6/38 (16%)
LRRCT 529..582 CDD:214507 13/57 (23%)
TIR 641..780 CDD:214587 29/158 (18%)
Blue background indicates that the domain is not in the aligned region.

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