Protein Alignment Toll-7 and LRRC17

DIOPT Version :9

• Sequence 1: NP_523797.1
• Gene: Toll-7 / 37272
• FlyBaseID: FBgn0034476
• Length: 1446
• Species: Drosophila melanogaster
• Sequence 2: NP_001026862.1
• Gene: LRRC17 / 10234
• HGNCID: 16895
• Length: 441
• Species: Homo sapiens
• Alignment Length: 438
• Identity: 109/438 - (24%)
• Similarity: 176/438 - (40%)
• Gaps: 109/438 - (24%)

  Fly   194 LDLGDNNLRQLPSGFLCPVGNLQVLNLTRNRIRTAEQMGFADMNCGAGSGSAGSELQVLDASHNE 258
            ||..:..|..:..|:  |...|.:| |.||:|||.:...|          |...:|:.||...||
Human    65 LDCQERKLVYVLPGW--PQDLLHML-LARNKIRTLKNNMF----------SKFKKLKSLDLQQNE 116

  Fly   259 LRSISESWGISRLRRLQHLNLAYNNLSELSGEALAGLASLRIVNLSNN------HLETL------ 311
            :..| ||.....|.:|..|.|.:|.:..|:.|.......|..:.|.:|      .:|||
Human   117 ISKI-ESEAFFGLNKLTTLLLQHNQIKVLTEEVFIYTPLLSYLRLYDNPWHCTCEIETLISMLQI 180

  Fly   312 PEGLFAG------------SKELREIHLQQ--NELYELPKGLFHRLEQLLVVD----LSGN-QLT 357
            |.....|            :|:||:|..:|  ||         ...|||   |    :||. .:.
Human   181 PRNRNLGNYAKCESPQEQKNKKLRQIKSEQLCNE---------EEKEQL---DPKPQVSGRPPVI 233

  Fly   358 SNHVDNTTFAGLIRLIVLNLAHNALTRIDYRTFKELYFLQILNLRNNSIGHIEDNAFLPLYNLHT 422
            ...||:|            ..||           .::.:|.|:.:...:..:.:|  :| .::..
Human   234 KPEVDST------------FCHN-----------YVFPIQTLDCKRKELKKVPNN--IP-PDIVK 272

  Fly   423 LNLAENRLHTLDDKLFNGLYVLSKLTLNNNLISVVEPAVFKNCSDLKELDLSSNQLNEVP-RALQ 486
            |:|:.|:::.|..|.|..::.|.||.|::|.|..::||.|...:.|:|||||:|.|.... ..|:
Human   273 LDLSYNKINQLRPKEFEDVHELKKLNLSSNGIEFIDPAAFLGLTHLEELDLSNNSLQNFDYGVLE 337

  Fly   487 DLAMLRTLDLGENQIRTFDN--------QSFKNLHQLTGLRLIDNQ------IGNITVGMFQDLP 537
            ||..|:.|.|.:|..|...|        :...|:| ..||.....:      :|......:::.|
Human   338 DLYFLKLLWLRDNPWRCDYNIHYLYYWLKHHYNVH-FNGLECKTPEEYKGWSVGKYIRSYYEECP 401

  Fly   538 RLSVLNLAKNRIQSIERGSFDKNFE-LEAIRLDRNFLADINGVFATLV 584
                    |:::.:... |||::.| .|..:..|:..|....|..|:|
Human   402 --------KDKLPAYPE-SFDQDTEDDEWEKKHRDHTAKKQSVIITIV 440

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Toll-7	NP_523797.1	LRR_8	135..201	CDD:290566	2/6 (33%)
		leucine-rich repeat	136..159	CDD:275380
		leucine-rich repeat	160..190	CDD:275380
		LRR_8	189..259	CDD:290566	19/64 (30%)
		leucine-rich repeat	191..214	CDD:275380	5/19 (26%)
		leucine-rich repeat	215..248	CDD:275380	10/32 (31%)
		LRR_RI	247..501	CDD:238064	75/285 (26%)
		LRR_8	247..308	CDD:290566	18/66 (27%)
		leucine-rich repeat	249..273	CDD:275380	9/23 (39%)
		leucine-rich repeat	274..297	CDD:275380	6/22 (27%)
		LRR_8	297..356	CDD:290566	21/89 (24%)
		leucine-rich repeat	298..321	CDD:275380	8/46 (17%)
		leucine-rich repeat	322..345	CDD:275380	6/24 (25%)
		LRR_8	345..406	CDD:290566	12/65 (18%)
		leucine-rich repeat	346..371	CDD:275380	7/29 (24%)
		leucine-rich repeat	372..395	CDD:275380	2/22 (9%)
		leucine-rich repeat	396..419	CDD:275380	4/22 (18%)
		LRR_8	419..478	CDD:290566	22/58 (38%)
		leucine-rich repeat	420..443	CDD:275380	6/22 (27%)
		leucine-rich repeat	444..467	CDD:275380	9/22 (41%)
		LRR_RI	466..622	CDD:238064	34/135 (25%)
		leucine-rich repeat	468..488	CDD:275380	9/20 (45%)
		LRR_8	491..549	CDD:290566	13/71 (18%)
		leucine-rich repeat	491..514	CDD:275380	7/30 (23%)
		leucine-rich repeat	515..536	CDD:275380	3/26 (12%)
		leucine-rich repeat	539..562	CDD:275380	4/22 (18%)
		leucine-rich repeat	563..585	CDD:275380	6/22 (27%)
		leucine-rich repeat	586..626	CDD:275380
		leucine-rich repeat	627..653	CDD:275380
		LRRCT	716..772	CDD:214507
		LRRNT	796..830	CDD:214470
		leucine-rich repeat	812..829	CDD:275380
		leucine-rich repeat	833..854	CDD:275380
		LRR_8	853..913	CDD:290566
		leucine-rich repeat	855..878	CDD:275380
		LRR_4	878..918	CDD:289563
		leucine-rich repeat	879..902	CDD:275380
		leucine-rich repeat	903..926	CDD:275380
		leucine-rich repeat	927..953	CDD:275380
		TIR	1098..1235	CDD:214587
LRRC17	NP_001026862.1	leucine-rich repeat	63..81	CDD:275380	4/17 (24%)
		LRR 1	82..103		9/31 (29%)
		LRR_8	84..141	CDD:290566	23/68 (34%)
		leucine-rich repeat	84..106	CDD:275380	10/32 (31%)
		LRR_4	105..146	CDD:289563	14/41 (34%)
		LRR 2	106..127		8/21 (38%)
		leucine-rich repeat	107..130	CDD:275380	9/23 (39%)
		LRR 3	130..151		6/20 (30%)
		leucine-rich repeat	131..154	CDD:275380	6/22 (27%)
		leucine-rich repeat	155..244	CDD:275380	24/112 (21%)
		leucine-rich repeat	249..269	CDD:275380	4/22 (18%)
		LRR_RI	<267..>351	CDD:238064	30/84 (36%)
		LRR 4	269..290		6/20 (30%)
		leucine-rich repeat	270..293	CDD:275380	6/22 (27%)
		LRR_8	272..328	CDD:290566	22/55 (40%)
		LRR 5	293..314		9/20 (45%)
		LRR_4	294..332	CDD:289563	17/37 (46%)
		leucine-rich repeat	294..317	CDD:275380	9/22 (41%)
		LRR 6	317..340		10/22 (45%)
		leucine-rich repeat	318..341	CDD:275380	11/22 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010