DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-7 and Chadl

DIOPT Version :9

Sequence 1:	NP_523797.1	Gene:	Toll-7 / 37272	FlyBaseID:	FBgn0034476	Length:	1446	Species:	Drosophila melanogaster
Sequence 2:	XP_038936217.1	Gene:	Chadl / 100910434	RGDID:	6504353	Length:	747	Species:	Rattus norvegicus

Alignment Length:	694	Identity:	170/694 - (24%)
Similarity:	260/694 - (37%)	Gaps:	191/694 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   478 LNEVPRALQDLAMLRTLDLGENQIRTFDNQSFKNLHQLTGLRLIDNQIGNITVGMFQDLPRLSVL 542
            |.|||..:.:|.  :.|||..|.::.....:|::|..||.|.|...|:..:..|.|:.|.||..|
  Rat    57 LTEVPDTIPELT--QRLDLQGNMLKVIPPAAFQDLPYLTHLDLQHCQVEQVAEGAFRGLGRLLFL 119

  Fly   543 NLAKNRIQSIERGSFDKNFELEAIRLDRNFLADIN-GVFATLVSLLWLNLSENHLV--------- 597
            |||.||:.|:.:.:.|....|..:.|:||.|.::. |.|..|.||..|||:.|.||
  Rat   120 NLASNRLSSLPQEALDGLGSLRRLELERNMLEELRPGTFGALGSLATLNLAHNALVYLPAMAFQG 184

  Fly   598 -----WFD-------------YAFIPSNLKWLDIHGNYIEALGNYYKLQEEIRVKTLDASHNRIT 644
                 |..             .|.:|. |:.|.:|.|.::||.. ..|.:...:..|:..||.:|
  Rat   185 LMRTRWLQLSHNALSVLAPEALAGLPV-LRRLSLHHNELQALPG-AALSQARSLARLELGHNPLT 247

  Fly   645 EIGP---MSIPNTIELLFINNNL--IGNVQPNAFVDKANLARVDLYANQLSKLQLQQLRVAPVVA 704
            ..|.   :::|...||...:.:|  :|   |.||.....|..:||..|||:.|       .|:..
  Rat   248 YTGEEDGLALPGLRELALDHGSLQALG---PRAFAHCPRLHTLDLRGNQLTTL-------PPLQV 302

  Fly   705 PKPLPEFYLGGNPFECDC----TMDWL--QRINNLTTRQHPRVMDMANIECVMPHARGAAVRPLS 763
            |..|....|.|||..|.|    .::||  .|:.:....:.||            ..||   ..|.
  Rat   303 PGQLRRLRLQGNPLWCACHARPLLEWLVRARVRSDGACRGPR------------RLRG---ETLD 352

  Fly   764 GLRPQDFLCRYESHCFALCHCCDFDACDCE----------------------MTCPSNCTCYHDQ 806
            .|||.|..             |..||.:.|                      ..||..|.|
  Rat   353 TLRPSDLR-------------CPGDAAEDEDEDRPAGPRSPPRSLHEEARWATPCPPACVC---- 400

  Fly   807 IWSTNVVDCGGQQTTELPRRVPMDSSVVYLDGNNFPVLKNHAFIGRKNLRALYVNGSQVAAIQNR 871
            :..|....|.|:....:||..|.|:.::.|..|:||.:...||.|.::|.:|::....:|.::..
  Rat   401 VGETRHSACDGRGLQAVPRGFPNDTQLLDLRRNHFPSVPRAAFPGLRHLVSLHLQHCGIAELEPG 465

  Fly   872 TFASLASLQLLHLADNKLRTLH----------GYEF----------------------------- 897
            ..|.|..|..|:|::|:|..|.          ||.:
  Rat   466 ALAGLDGLVYLYLSNNQLSGLSAAALEGAPNLGYLYLEHNRFLRIPGAALRALPRLFSLHLQDNA 530

  Fly   898 -EQLS--------ALRELYLQNNQLTTIENATLAPLAALELIRIDGNRLVTLPIWQMHATHFGTR 953
             ::|:        |||.|||..|.:|.:....|.|...||.:.:|.|:|..:|...:...   ..
  Rat   531 VDRLAPGDLAGARALRGLYLSGNHITQVSPGALGPARELEKLHLDRNQLRQVPTGALEGL---PA 592

  Fly   954 LKSISLGRNQWSCRCQFLQALTSYVADNAL--IVQDAQDIYCMAASSGTGSAALEDSSSNSGSLE 1016
            ||.:.|.||.:..           :.|.|.  :.:..|.::       ..|:.||..|..:
  Rat   593 LKELQLSRNPFRA-----------LHDGAFQPVGRSLQQLF-------LNSSDLEQISPRA---- 635

  Fly  1017 KRELDFNATGAACTDYYSGGSMLQHGIPESYIPLLAAALALLFL 1060
                 |:..|......|...:.|| .:|   .|:..:.|.|:.|
  Rat   636 -----FSGLGKGLQGLYLQQNQLQ-SLP---APMWLSGLELIDL 670

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-7	NP_523797.1	LRR_8	135..201	CDD:290566
		leucine-rich repeat	136..159	CDD:275380
		leucine-rich repeat	160..190	CDD:275380
		LRR_8	189..259	CDD:290566
		leucine-rich repeat	191..214	CDD:275380
		leucine-rich repeat	215..248	CDD:275380
		LRR_RI	247..501	CDD:238064	9/22 (41%)
		LRR_8	247..308	CDD:290566
		leucine-rich repeat	249..273	CDD:275380
		leucine-rich repeat	274..297	CDD:275380
		LRR_8	297..356	CDD:290566
		leucine-rich repeat	298..321	CDD:275380
		leucine-rich repeat	322..345	CDD:275380
		LRR_8	345..406	CDD:290566
		leucine-rich repeat	346..371	CDD:275380
		leucine-rich repeat	372..395	CDD:275380
		leucine-rich repeat	396..419	CDD:275380
		LRR_8	419..478	CDD:290566	170/694 (24%)
		leucine-rich repeat	420..443	CDD:275380
		leucine-rich repeat	444..467	CDD:275380
		LRR_RI	466..622	CDD:238064	53/171 (31%)
		leucine-rich repeat	468..488	CDD:275380	4/9 (44%)
		LRR_8	491..549	CDD:290566	21/57 (37%)
		leucine-rich repeat	491..514	CDD:275380	6/22 (27%)
		leucine-rich repeat	515..536	CDD:275380	7/20 (35%)
		leucine-rich repeat	539..562	CDD:275380	9/22 (41%)
		leucine-rich repeat	563..585	CDD:275380	8/22 (36%)
		leucine-rich repeat	586..626	CDD:275380	16/66 (24%)
		leucine-rich repeat	627..653	CDD:275380	6/28 (21%)
		LRRCT	716..772	CDD:214507	16/61 (26%)
		LRRNT	796..830	CDD:214470	10/33 (30%)
		leucine-rich repeat	812..829	CDD:275380	4/16 (25%)
		leucine-rich repeat	833..854	CDD:275380	7/20 (35%)
		LRR_8	853..913	CDD:290566	21/107 (20%)
		leucine-rich repeat	855..878	CDD:275380	5/22 (23%)
		LRR_4	878..918	CDD:289563	17/87 (20%)
		leucine-rich repeat	879..902	CDD:275380	9/70 (13%)
		leucine-rich repeat	903..926	CDD:275380	9/22 (41%)
		leucine-rich repeat	927..953	CDD:275380	6/25 (24%)
		TIR	1098..1235	CDD:214587
Chadl	XP_038936217.1	PLN00113	30..>555	CDD:215061	139/543 (26%)
		leucine-rich repeat	48..66	CDD:275380	4/8 (50%)
		leucine-rich repeat	68..91	CDD:275380	6/24 (25%)
		leucine-rich repeat	92..115	CDD:275380	8/22 (36%)
		leucine-rich repeat	116..139	CDD:275380	9/22 (41%)
		leucine-rich repeat	140..163	CDD:275380	8/22 (36%)
		leucine-rich repeat	164..187	CDD:275380	7/22 (32%)
		leucine-rich repeat	188..211	CDD:275380	2/22 (9%)
		leucine-rich repeat	212..235	CDD:275380	7/23 (30%)
		leucine-rich repeat	236..259	CDD:275380	5/22 (23%)
		leucine-rich repeat	260..283	CDD:275380	7/25 (28%)
		leucine-rich repeat	306..345	CDD:275380	12/50 (24%)
		leucine-rich repeat	425..448	CDD:275380	7/22 (32%)
		PPP1R42	446..603	CDD:411060	35/159 (22%)
		leucine-rich repeat	449..472	CDD:275380	5/22 (23%)
		leucine-rich repeat	473..496	CDD:275380	6/22 (27%)
		leucine-rich repeat	497..520	CDD:275380	2/22 (9%)
		leucine-rich repeat	521..544	CDD:275380	1/22 (5%)
		leucine-rich repeat	545..568	CDD:275380	9/22 (41%)
		leucine-rich repeat	569..592	CDD:275380	6/25 (24%)
		LRR_8	591..653	CDD:404697	15/88 (17%)
		leucine-rich repeat	593..617	CDD:275380	7/34 (21%)
		leucine-rich repeat	618..641	CDD:275380	6/38 (16%)
		leucine-rich repeat	643..665	CDD:275380	5/25 (20%)
		leucine-rich repeat	666..677	CDD:275378	2/5 (40%)
		LRRCT	673..721	CDD:214507
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010