DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Toll-7 and nyx

DIOPT Version :9

Sequence 1:	NP_523797.1	Gene:	Toll-7 / 37272	FlyBaseID:	FBgn0034476	Length:	1446	Species:	Drosophila melanogaster
Sequence 2:	XP_031752664.1	Gene:	nyx / 100495354	XenbaseID:	XB-GENE-949924	Length:	468	Species:	Xenopus tropicalis

Alignment Length:	476	Identity:	118/476 - (24%)
Similarity:	179/476 - (37%)	Gaps:	128/476 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   277 LNLAYNNLSELSGEALAGLASLRIVNLSNNHLETLPEGLFAGSKELREIHLQQNELYELPKGLFH 341
            :||..||:..|...|...|..|:.::||:|::..:..|.|.|...|.|:.:..||..
Frog    64 INLDKNNIKFLYERAFGTLPLLKGLSLSHNNISFITPGAFKGLPNLTELKMAHNEYI-------- 120

  Fly   342 RLEQLLVVDLSGNQLTSNHVDNTTFAGLIRLIVLNLAHNALTRIDYRTFKELYFLQILNLRNNSI 406
                             .::...||:.|.:|:.|:||...|..|..|.|.||..|..|....|:.
Frog   121 -----------------RYLHTRTFSVLKKLVKLDLADCNLFNIPDRIFVELPSLHELIFFQNNF 168

  Fly   407 GHIEDNAFLPLYNLHTLNLAENRLHTLDDKLFNGLYVLSKLTLNNNLISVVEPAVFKNCSDLKEL 471
            ..| ..|...:.||..:.|..||:..:.......|..|..|.|.:|.|:|:....|::|..|:.|
Frog   169 RRI-PGAIRGMENLTHIYLESNRIEAVAYNSLQDLINLKYLNLQDNKINVIHDRSFQDCQKLEYL 232

  Fly   472 DLSSNQLNEVPRALQDLAMLRTLDLGENQIRTFDNQSFKNLHQLTGLRLIDNQIGNITVGMFQDL 536
            .|:.|.|||:|               ||        |||.|..|..|.|..|.|.|::...||||
Frog   233 YLNDNLLNELP---------------EN--------SFKGLKCLKMLNLGGNFIRNVSSAWFQDL 274

  Fly   537 PRLSVLNLAKNRIQSIERGSFDKNFELEAIRLDRNFLADINGVFATLVSLLWLNLSENHLVWFDY 601
            ..|.||.|.:|||..||.|:|:                       .|.||:.|:|:.|:|....:
Frog   275 VELEVLYLDRNRISYIEEGAFE-----------------------NLTSLVTLHLNSNNLTTLPF 316

  Fly   602 -AFIP-----------------SNLKWLDIHGNYIEALGNYYKLQEEIRVKT------------- 635
             .|.|                 ..:|||.      :.:.| |||..::....
Frog   317 EVFRPVYFLGRLFLFRNPWECDCRIKWLQ------DWMDN-YKLVRDVPCSAPALVAGMDLSSIL 374

  Fly   636 ---------LDASHNRITEIGPM---SIPNTIE--LLFINNNLI---GNVQPNA-FVDKANLARV 682
                     ||.:....|...|:   .:.:|:|  |..:.:.|:   ||.:.:. ..|.::...:
Frog   375 LKKSQDGVCLDPTDENFTYFVPLPTDGLQSTMETKLSSLISRLLLPKGNYEASGNITDSSDNTTL 439

  Fly   683 DLYANQLSKLQLQQLRVAPVV 703
            ....|..|.|.|.|..:|.::
Frog   440 SDGKNTASSLDLSQKVIAHIL 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-7	NP_523797.1	LRR_8	135..201	CDD:290566
		leucine-rich repeat	136..159	CDD:275380
		leucine-rich repeat	160..190	CDD:275380
		LRR_8	189..259	CDD:290566
		leucine-rich repeat	191..214	CDD:275380
		leucine-rich repeat	215..248	CDD:275380
		LRR_RI	247..501	CDD:238064	60/223 (27%)
		LRR_8	247..308	CDD:290566	11/30 (37%)
		leucine-rich repeat	249..273	CDD:275380
		leucine-rich repeat	274..297	CDD:275380	7/19 (37%)
		LRR_8	297..356	CDD:290566	11/58 (19%)
		leucine-rich repeat	298..321	CDD:275380	7/22 (32%)
		leucine-rich repeat	322..345	CDD:275380	4/22 (18%)
		LRR_8	345..406	CDD:290566	16/60 (27%)
		leucine-rich repeat	346..371	CDD:275380	3/24 (13%)
		leucine-rich repeat	372..395	CDD:275380	10/22 (45%)
		leucine-rich repeat	396..419	CDD:275380	5/22 (23%)
		LRR_8	419..478	CDD:290566	18/58 (31%)
		leucine-rich repeat	420..443	CDD:275380	5/22 (23%)
		leucine-rich repeat	444..467	CDD:275380	8/22 (36%)
		LRR_RI	466..622	CDD:238064	47/173 (27%)
		leucine-rich repeat	468..488	CDD:275380	8/19 (42%)
		LRR_8	491..549	CDD:290566	21/57 (37%)
		leucine-rich repeat	491..514	CDD:275380	6/22 (27%)
		leucine-rich repeat	515..536	CDD:275380	8/20 (40%)
		leucine-rich repeat	539..562	CDD:275380	11/22 (50%)
		leucine-rich repeat	563..585	CDD:275380	1/21 (5%)
		leucine-rich repeat	586..626	CDD:275380	11/57 (19%)
		leucine-rich repeat	627..653	CDD:275380	5/50 (10%)
		LRRCT	716..772	CDD:214507
		LRRNT	796..830	CDD:214470
		leucine-rich repeat	812..829	CDD:275380
		leucine-rich repeat	833..854	CDD:275380
		LRR_8	853..913	CDD:290566
		leucine-rich repeat	855..878	CDD:275380
		LRR_4	878..918	CDD:289563
		leucine-rich repeat	879..902	CDD:275380
		leucine-rich repeat	903..926	CDD:275380
		leucine-rich repeat	927..953	CDD:275380
		TIR	1098..1235	CDD:214587
nyx	XP_031752664.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010