DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-7 and tlr9

DIOPT Version :9

Sequence 1:	NP_523797.1	Gene:	Toll-7 / 37272	FlyBaseID:	FBgn0034476	Length:	1446	Species:	Drosophila melanogaster
Sequence 2:	XP_017948709.2	Gene:	tlr9 / 100494387	XenbaseID:	XB-GENE-486908	Length:	1035	Species:	Xenopus tropicalis

Alignment Length:	1217	Identity:	266/1217 - (21%)
Similarity:	463/1217 - (38%)	Gaps:	326/1217 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 DGSSQLTIQCSELYLFESTLPVAVFARLQTLEALRLDSCKLLQLPNNAFEGLATLKSLRLSTH-- 168
            |.::..|:.|.|..|..  :|..|...::..: |.::..:|  |.|:.|.|:..|..|.||.:
Frog    44 DFNNASTVICRERQLIH--VPHIVSQSVKVFD-LAINEIRL--LANSTFSGVPNLVILNLSDNCQ 103

  Fly   169 NSEWGPTR---TLELFPDSLGGLKQLTDLDLGDNNLRQLPSGFLCPV-GNLQVLNLTRNRIRTAE 229
            .|...|.:   .|.:.|.:|..||.||:|||..|:|..:|     |: .|::.|||..|:|.
Frog   104 PSNLRPYKEICRLIIEPHALVSLKSLTNLDLSGNSLTSIP-----PLPENIKFLNLNLNQIH--- 160

  Fly   230 QMGFADMNCGAGSGSAGSELQVLDASHNELRSISESWGISRLRRLQHLNLAYNNLSELSGEALAG 294
                                            :...|..|||..::.:.|.||.......|..
Frog   161 --------------------------------MISGWEFSRLNNVKMIRLGYNCFYSKQCEPF-- 191

  Fly   295 LASLRIVNLSNNHLETLPEGLFAGSKELREIHLQQNELYELPKGLFHRLEQLLVVDLSGNQLTSN 359
                        ||.   :..|..::.|.|:.|..|.:...|:.|   ...:.::|||.|:::.
Frog   192 ------------HLS---DSAFINNEFLEELALSFNNITSFPQNL---PSSIRILDLSENKISK- 237

  Fly   360 HVDNTTFAGLIRLIVLNLAHNALTRIDYRTFKELYFLQILNLRNNSIGHIEDNAFLPLYNLHTLN 424
             :|......|..|..|:|..|. .|.|: ..:..|     ..:|||...:....|..|:.|..||
Frog   238 -IDREDLCNLNNLHSLDLQWNC-QRCDH-ALQACY-----PCKNNSALLLVPGVFDCLHKLSYLN 294

  Fly   425 LAENRLHTLDDKLFNGLYVLSKLTLNNNLISVVEPAVFKNCSDLKELDLSSNQLNEVPRALQDLA 489
            |..|.||||...||:.|..||.|.|::|.:::.....|...:::|||:|..|        .:..:
Frog   295 LRGNSLHTLHSSLFSSLTNLSHLVLSDNFLNLETETFFSALTNVKELNLDFN--------FKPYS 351

  Fly   490 MLRTLDLGENQIRTFDNQSFKNLHQLTGLRLIDNQIGNITVGMFQD-------LPRLSVLNLAKN 547
            |...|.|..|..|      .|:|.::|            .||.|.:       :|.||:.||.:
Frog   352 MYERLVLNSNVAR------MKSLERIT------------IVGYFFNVLDEEGIMPLLSLPNLRE- 397

  Fly   548 RIQSIERGSFDKNFELEAIRLDRNFLADIN-GVFATLVSLLWLNLSENHLVWFDYAFIPSNLKWL 611
                              |.|..||:..:| .:..|...|.:::||||.:.:.::.
Frog   398 ------------------ISLRTNFILKVNLSMLFTHKPLRFISLSENLISFEEHK--------- 435

  Fly   612 DIHGNYIEALGNYYKLQEEIRVKTLDASH--NRITEIGPMSIP------NTIELLFINNNLIGNV 668
              ||..:......:....::....:| ||  .:..|.|.:..|      ::::|.|   |.||::
Frog   436 --HGQKLAMHPPLFDRGNQVDGGWMD-SHCGPKQVEAGEVEYPGCWQYNHSVDLSF---NNIGSI 494

  Fly   669 QPNAFVDKANLARVDL---YANQ-LSKLQLQQLRVAPVVAPKPLPEFYLGGNPFECDCTMDWLQR 729
            .|:.|:....:..:::   |.|| |:..|...|        |.|....|..|.|:    |.:.:.
Frog   495 YPDEFLGMDEIECLNMSYNYINQRLNGTQFGHL--------KSLRHLDLSHNRFD----MYYYKA 547

  Fly   730 INNLTTRQHPR--VMDMANIECVMPHARGAAVRPLSGLRPQDFLCRYESHCFALCHCCDFDACDC 792
            ::.|     ||  ::::|:.:                         |:.....:.|..||
Frog   548 LSEL-----PRLKILNLAHND-------------------------YQFMMKGVNHRLDF----- 577

  Fly   793 EMTCPSNCTCYHDQIWSTNVVDCGGQQTTELP---------RRVPMDSSVVYLDGNNFPVLKNHA 848
                ..|.|...:...:.|.:  |.:.|.||.         |...:.||..|  |.:..:   :.
Frog   578 ----LENLTSLVELNLNNNFI--GLRITRELKSHSLETLRFRNNELGSSWQY--GKDTYL---NM 631

  Fly   849 FIGRKNLRALYVNGSQVAAIQNRTFASL-ASLQLLHLADNKLRTLHGYEFEQLSALRELYLQNNQ 912
            |...::|:.|.::.:|:..|.|.....| .|||.|:|:.|||.|.:..:...|..|..|.|..|.
Frog   632 FTNLRSLKILDISYNQLPVIPNEVLEKLPESLQKLNLSHNKLYTFNWAKTAHLGNLAILDLGFNA 696

  Fly   913 LTTIE-NATLAPLAALEL---------------------IRIDGNRLVTLPIWQMHAT----HFG 951
            ||.:. |.|.:.:|.|.|                     :.:..|.:.|:     |.|    :|.
Frog   697 LTKLRANLTESNIAFLNLTYNKINSLDKDFFDSFSELKQLILSNNLIKTI-----HITSFPINFL 756

  Fly   952 TRLKSISLGRNQWSCRCQFLQALTSYVADNALIVQDAQDIYCMAASSGTGSAALEDSSSNSGSLE 1016
            ..|.|:.:..|.:.|.|:....:|..:.....:...:..:.|.:..|..|.:.|        |::
Frog   757 QNLDSLDVSGNPFQCTCKAYWFITFLMETEVTVDHLSTGMKCDSPDSLRGRSLL--------SMD 813

  Fly  1017 KRELDFNATGAACTDYYSGGSMLQHGIPESYIPLLAAALALLFLLVVIAMVFAFRESLRIWLFAH 1081
            .:         :|.:.|            .::..:.:::.::||:|:..:...|..:|  |...|
Frog   814 PQ---------SCQELY------------GHVCFIWSSILVIFLMVIPTIWNLFFWNL--WYAGH 855

  Fly  1082 YGV---RVFGPRCEESEKLYDAVLLHSAKDS---EFVCQHLAAQLET-GRPPLRVCLQHRD-LAH 1138
            ..|   |.:....::|.:.:||.:..:.|:|   ::|...|..|||: .|....:||:.|| :|.
Frog   856 LIVATLRSYTKLHDKSTEHFDAFIAFNTKNSSVRDWVYNELLVQLESPERGGFTLCLEERDWIAG 920

  Fly  1139 DATHYQLLEATRVSRRVVILLTRNFLQTEWARCELRRSVHDALRGRPQKLVIIEEPEVAFEA-ES 1202
            .::...|.::...|::.:.::||     ||..|.|.|   .|.....|:|:..::..||... :.
Frog   921 RSSIENLYDSIYRSKKTIFIITR-----EWFNCGLLR---HAFFMSNQRLLDEKKDVVALVVLDH 977

  Fly  1203 DIELLPYLKTSAVHRIR-------------RSDRHFWEKLRYALPVD 1236
            .:::..|..|    |.|             ::..|||..||..:..|
Frog   978 KMKMSQYFLT----RKRLCPKSFLNWPCNPKAHSHFWHMLRIYIRQD 1020

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-7	NP_523797.1	LRR_8	135..201	CDD:290566	23/70 (33%)
		leucine-rich repeat	136..159	CDD:275380	6/22 (27%)
		leucine-rich repeat	160..190	CDD:275380	10/34 (29%)
		LRR_8	189..259	CDD:290566	16/70 (23%)
		leucine-rich repeat	191..214	CDD:275380	9/23 (39%)
		leucine-rich repeat	215..248	CDD:275380	5/32 (16%)
		LRR_RI	247..501	CDD:238064	62/253 (25%)
		LRR_8	247..308	CDD:290566	8/60 (13%)
		leucine-rich repeat	249..273	CDD:275380	4/23 (17%)
		leucine-rich repeat	274..297	CDD:275380	4/22 (18%)
		LRR_8	297..356	CDD:290566	13/58 (22%)
		leucine-rich repeat	298..321	CDD:275380	3/22 (14%)
		leucine-rich repeat	322..345	CDD:275380	6/22 (27%)
		LRR_8	345..406	CDD:290566	15/60 (25%)
		leucine-rich repeat	346..371	CDD:275380	6/24 (25%)
		leucine-rich repeat	372..395	CDD:275380	6/22 (27%)
		leucine-rich repeat	396..419	CDD:275380	5/22 (23%)
		LRR_8	419..478	CDD:290566	23/58 (40%)
		leucine-rich repeat	420..443	CDD:275380	12/22 (55%)
		leucine-rich repeat	444..467	CDD:275380	6/22 (27%)
		LRR_RI	466..622	CDD:238064	34/163 (21%)
		leucine-rich repeat	468..488	CDD:275380	5/19 (26%)
		LRR_8	491..549	CDD:290566	15/64 (23%)
		leucine-rich repeat	491..514	CDD:275380	6/22 (27%)
		leucine-rich repeat	515..536	CDD:275380	4/27 (15%)
		leucine-rich repeat	539..562	CDD:275380	4/22 (18%)
		leucine-rich repeat	563..585	CDD:275380	6/22 (27%)
		leucine-rich repeat	586..626	CDD:275380	7/39 (18%)
		leucine-rich repeat	627..653	CDD:275380	6/33 (18%)
		LRRCT	716..772	CDD:214507	7/57 (12%)
		LRRNT	796..830	CDD:214470	8/42 (19%)
		leucine-rich repeat	812..829	CDD:275380	5/25 (20%)
		leucine-rich repeat	833..854	CDD:275380	3/20 (15%)
		LRR_8	853..913	CDD:290566	20/60 (33%)
		leucine-rich repeat	855..878	CDD:275380	6/23 (26%)
		LRR_4	878..918	CDD:289563	16/40 (40%)
		leucine-rich repeat	879..902	CDD:275380	9/22 (41%)
		leucine-rich repeat	903..926	CDD:275380	8/23 (35%)
		leucine-rich repeat	927..953	CDD:275380	7/50 (14%)
		TIR	1098..1235	CDD:214587	38/155 (25%)
tlr9	XP_017948709.2	leucine-rich repeat	69..92	CDD:275380	6/25 (24%)
		PLN00113	82..>592	CDD:215061	152/689 (22%)
		leucine-rich repeat	93..128	CDD:275380	10/34 (29%)
		leucine-rich repeat	129..148	CDD:275380	9/23 (39%)
		leucine-rich repeat	149..172	CDD:275380	9/57 (16%)
		leucine-rich repeat	173..203	CDD:275380	7/46 (15%)
		leucine-rich repeat	204..224	CDD:275380	6/22 (27%)
		leucine-rich repeat	225..248	CDD:275380	6/24 (25%)
		leucine-rich repeat	249..289	CDD:275380	12/46 (26%)
		leucine-rich repeat	290..311	CDD:275380	11/20 (55%)
		leucine-rich repeat	314..337	CDD:275380	6/22 (27%)
		leucine-rich repeat	353..394	CDD:275380	13/58 (22%)
		leucine-rich repeat	395..418	CDD:275380	7/41 (17%)
		leucine-rich repeat	482..504	CDD:275380	7/24 (29%)
		leucine-rich repeat	505..529	CDD:275380	6/31 (19%)
		leucine-rich repeat	530..553	CDD:275380	6/31 (19%)
		inl_like_NEAT_1	<534..>767	CDD:411101	59/287 (21%)
		leucine-rich repeat	554..583	CDD:275380	6/62 (10%)
		leucine-rich repeat	584..637	CDD:275380	11/59 (19%)
		leucine-rich repeat	607..629	CDD:275380	5/23 (22%)
		leucine-rich repeat	638..662	CDD:275380	6/23 (26%)
		leucine-rich repeat	663..686	CDD:275380	9/22 (41%)
		leucine-rich repeat	687..708	CDD:275380	8/20 (40%)
		leucine-rich repeat	709..732	CDD:275380	3/22 (14%)
		leucine-rich repeat	733..751	CDD:275380	4/22 (18%)
		PCC	738..>821	CDD:188093	17/104 (16%)
		TIR_2	875..1017	CDD:419986	38/153 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920