DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-7 and tlr6

DIOPT Version :9

Sequence 1:	NP_523797.1	Gene:	Toll-7 / 37272	FlyBaseID:	FBgn0034476	Length:	1446	Species:	Drosophila melanogaster
Sequence 2:	XP_017950845.1	Gene:	tlr6 / 100493946	XenbaseID:	XB-GENE-492949	Length:	842	Species:	Xenopus tropicalis

Alignment Length:	1118	Identity:	191/1118 - (17%)
Similarity:	367/1118 - (32%)	Gaps:	443/1118 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   182 PDSLGGLKQLTDLDLGDNNLRQLPSGFLCPVGNLQVLNLTRNRIRTAEQMGFADMNCGAGSGSAG 246
            |.:|..|  .|.||:..|::..:.:.....:.:|||||.:.|:::......|          ...
Frog    39 PKNLSSL--TTVLDISFNSIATMETSEFNYIFDLQVLNASYNKMKYLNSSIF----------KFN 91

  Fly   247 SELQVLDASHNELRSISESWGISRLRRLQHLNLAYNNLSELSGEALAGLASLRIVNLSNNHLETL 311
            ::||.||.|||.||:||.::.    ..:|||::::||...||  ..:|..::.::.......:.:
Frog    92 TQLQYLDFSHNVLRNISGTFP----SHIQHLDISFNNFQTLS--VCSGFGNMVLLEYLGLGADQI 150

  Fly   312 PEGLFAG--SKELREIHLQQNELYELPKGLFHRLEQLLVVD-----LSGNQLTSNHVDNTTFAGL 369
            .:..|.|  ...|:|:.::.|.|.:...|      .||:::     |....|::....|..|..:
Frog   151 LKSDFEGIVHLHLKEVFIELNSLNDYENG------SLLLLNTKKLTLDFGVLSNEDRYNVLFDAV 209

  Fly   370 IRLIVLNLAHNALTRIDYRTFKELYFLQILNLRNNSIGHIEDNAFLPLYNLHTLNLAENRLHTLD 434
            ....||.|:|                ||..|:      ||:...::       .|:.:|
Frog   210 NTTSVLELSH----------------LQRWNI------HIDPKKYI-------FNIVQN------ 239

  Fly   435 DKLFNGLYVLSKLTLNNNLISVVEPAVFKNCSDLKELDLSSNQLN----EVPRALQDL--AMLRT 493
                      ||:|                       ||:...:|    .:..|||.:  :.:.|
Frog   240 ----------SKVT-----------------------DLTMRHVNVEWKMIVLALQYIWHSSVET 271

  Fly   494 LDLGENQIRTFDNQSFKNL-------HQLTGLRLIDNQIGNITVGMFQDLPRLSVLNLAKNRIQS 551
            |        ||.:.|.|.|       :..|.::.::.|  .:.||:||
Frog   272 L--------TFYDFSLKGLIAKTSFDYSNTSVKAVNVQ--GVNVGVFQ----------------- 309

  Fly   552 IERGSFDK--------NFELEAIRLDRNFLADINGVFATLVSLLW-LNLSENHLVWFDYAFIPSN 607
                 ||:        |..:|.:.|:          ||:|:.::. ||.|
Frog   310 -----FDQSSVYRVFSNMNIENLTLN----------FASLLFMVCPLNSS--------------- 344

  Fly   608 LKWLDIHGNYIEALGNYYKLQEEIRVKTLDASHNRITEIGPMSIPNTIELLFINNNLIGNVQPNA 672
                                    ..:::|.|||.:|:                         :.
Frog   345 ------------------------TFQSIDFSHNALTD-------------------------DL 360

  Fly   673 FVD---KANLARVDLYANQLSKLQLQQLRVAPVVAPKPLPEFYLGGNPFECDCTMDWLQRINNLT 734
            |.|   ..||.|:.|..|:|.|:    .:::.:....|               ::::|...:||.
Frog   361 FKDCFTLINLKRLKLRKNKLEKI----YKLSAMTENMP---------------SLEYLDASHNLL 406

  Fly   735 TRQHPRVMDMANIECVMPHARGAAVRPLSGLRPQDFLCRYESHCFALCHCCDFDACDCEMTCPSN 799
            .                                                   :|..||.
Frog   407 A---------------------------------------------------YDEEDCH------ 414

  Fly   800 CTCYHDQIWSTNVVD---CGGQQTTELPRRVPMDSSVVYLDGNNFPVLKNHAFIGRKNLRALYVN 861
                    ||.|:|:   .....|..:.:.:|:...::.|:.|:.    .|...|
Frog   415 --------WSQNIVELNLASNFLTASIFKCLPISIKILILESNDI----THVPSG---------- 457

  Fly   862 GSQVAAIQNRTFASLASLQLLHLADNKLRTLHGYEFEQLSALRELYLQNNQLTTIENATLAPLAA 926
                               :.||.|                |.||.|..|:|..:.:.  :.:::
Frog   458 -------------------VTHLDD----------------LVELNLSFNRLGDLPDC--SNISS 485

  Fly   927 LELIRIDGNRLVTLPIWQMHATHFGTRLKSISLGRNQWSCRCQFLQALTSYVADNALIVQDAQDI 991
            |.|:.::||:::...|..:.:.   :|:|.||.|:|.:.|.|:..:.:.........::...:..
Frog   486 LSLLGVEGNQILYPSIESIESC---SRVKHISAGQNPFQCNCELRRFINQEKEAPGTLIGWPEAY 547

  Fly   992 YCMAASSGTGSAALEDSSSNSGSLEKRELDFNATGAACTDYYSGGSMLQHGIPESYIPLLAAALA 1056
            .|            :......|::.|   ||..:...|..:.             .||::
Frog   548 VC------------KYPDHLRGTMLK---DFYISEITCNVFI-------------LIPVI----- 579

  Fly  1057 LLFLLVVIAMVFAFRESL-------RIWLFAHYGVRV----FGPRCEESEKLYDAVLLHSAKDSE 1110
            :|.:::.||::....:.|       .||.:.....|.    .|.:..:.:..::|.:.:|..|:.
Frog   580 ILPIIISIALIIGLCKYLDGPWFLKMIWQYTRTKQRTRTSKQGYQSLQRDFDFNAFISYSEHDAS 644

  Fly  1111 FVCQHLAAQLETGRPPLRVCLQHRDLAHDATHYQ-LLEATRVSRRVVILLTRNFLQTEWARCELR 1174
            :|.......:|.....:|:|...|:.....:..: ::.....|.:.:.:|:.||:|:||...||.
Frog   645 WVKNIFLPSIERSNDCIRICQHERNFIPGKSIIENIINCIEKSYKSIFILSPNFVQSEWCHYELY 709

  Fly  1175 RSVHDALRGRPQKLVIIEEPEVAFEAESDIELLP-YLKTSAVHRIR-------------RSDRH- 1224
            .:.|.........|::|.           :|.:| ||..|..::::             ...:|
Frog   710 FAHHKLYTENNDNLILIL-----------LEPIPQYLIPSKYYKLKTLMAQRTYLEWPSEKSKHG 763

  Fly  1225 -FWEKLRYALPVD 1236
             ||..||.|:.:|
Frog   764 LFWANLRAAISID 776

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-7	NP_523797.1	LRR_8	135..201	CDD:290566	7/18 (39%)
		leucine-rich repeat	136..159	CDD:275380
		leucine-rich repeat	160..190	CDD:275380	3/7 (43%)
		LRR_8	189..259	CDD:290566	18/69 (26%)
		leucine-rich repeat	191..214	CDD:275380	4/22 (18%)
		leucine-rich repeat	215..248	CDD:275380	7/32 (22%)
		LRR_RI	247..501	CDD:238064	54/266 (20%)
		LRR_8	247..308	CDD:290566	19/60 (32%)
		leucine-rich repeat	249..273	CDD:275380	11/23 (48%)
		leucine-rich repeat	274..297	CDD:275380	8/22 (36%)
		LRR_8	297..356	CDD:290566	10/65 (15%)
		leucine-rich repeat	298..321	CDD:275380	2/24 (8%)
		leucine-rich repeat	322..345	CDD:275380	5/22 (23%)
		LRR_8	345..406	CDD:290566	13/65 (20%)
		leucine-rich repeat	346..371	CDD:275380	6/29 (21%)
		leucine-rich repeat	372..395	CDD:275380	4/22 (18%)
		leucine-rich repeat	396..419	CDD:275380	5/22 (23%)
		LRR_8	419..478	CDD:290566	7/58 (12%)
		leucine-rich repeat	420..443	CDD:275380	2/22 (9%)
		leucine-rich repeat	444..467	CDD:275380	3/22 (14%)
		LRR_RI	466..622	CDD:238064	30/177 (17%)
		leucine-rich repeat	468..488	CDD:275380	6/23 (26%)
		LRR_8	491..549	CDD:290566	13/64 (20%)
		leucine-rich repeat	491..514	CDD:275380	7/29 (24%)
		leucine-rich repeat	515..536	CDD:275380	6/20 (30%)
		leucine-rich repeat	539..562	CDD:275380	3/30 (10%)
		leucine-rich repeat	563..585	CDD:275380	5/21 (24%)
		leucine-rich repeat	586..626	CDD:275380	3/40 (8%)
		leucine-rich repeat	627..653	CDD:275380	5/25 (20%)
		LRRCT	716..772	CDD:214507	3/55 (5%)
		LRRNT	796..830	CDD:214470	6/36 (17%)
		leucine-rich repeat	812..829	CDD:275380	2/19 (11%)
		leucine-rich repeat	833..854	CDD:275380	4/20 (20%)
		LRR_8	853..913	CDD:290566	8/59 (14%)
		leucine-rich repeat	855..878	CDD:275380	0/22 (0%)
		LRR_4	878..918	CDD:289563	9/39 (23%)
		leucine-rich repeat	879..902	CDD:275380	3/22 (14%)
		leucine-rich repeat	903..926	CDD:275380	6/22 (27%)
		leucine-rich repeat	927..953	CDD:275380	5/25 (20%)
		TIR	1098..1235	CDD:214587	31/153 (20%)
tlr6	XP_017950845.1	leucine-rich repeat	46..69	CDD:275378	4/22 (18%)
		LRR_8	70..125	CDD:404697	22/68 (32%)
		leucine-rich repeat	70..93	CDD:275378	7/32 (22%)
		leucine-rich repeat	94..114	CDD:275378	11/23 (48%)
		leucine-rich repeat	115..139	CDD:275378	8/25 (32%)
		LRR_RI	311..>478	CDD:423007	50/373 (13%)
		leucine-rich repeat	347..369	CDD:275380	7/46 (15%)
		leucine-rich repeat	370..395	CDD:275380	7/43 (16%)
		leucine-rich repeat	396..418	CDD:275380	8/86 (9%)
		leucine-rich repeat	419..440	CDD:275380	3/20 (15%)
		leucine-rich repeat	441..463	CDD:275380	6/54 (11%)
		leucine-rich repeat	464..485	CDD:275380	6/22 (27%)
		leucine-rich repeat	486..509	CDD:275380	5/25 (20%)
		LRRCT	518..570	CDD:214507	8/66 (12%)
		TIR	632..775	CDD:214587	31/153 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X221
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920