DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-7 and lingo2

DIOPT Version :9

Sequence 1:	NP_523797.1	Gene:	Toll-7 / 37272	FlyBaseID:	FBgn0034476	Length:	1446	Species:	Drosophila melanogaster
Sequence 2:	XP_004910881.1	Gene:	lingo2 / 100490134	XenbaseID:	XB-GENE-922286	Length:	612	Species:	Xenopus tropicalis

Alignment Length:	398	Identity:	102/398 - (25%)
Similarity:	178/398 - (44%)	Gaps:	62/398 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   248 ELQVLDASHNELRSISESWGISRLRRLQHLNLAYNNLSELSGEALAGLASLRIVNLSNNHLETLP 312
            |.::||.|.|:|:|::....:| ...|:.::|:.|.:|.:...|...|.:||.::|..|.|:.:|
Frog    62 ETKILDLSKNKLKSVNPVDFVS-YPLLEDIDLSDNIISNVEPGAFNSLFNLRSLSLKGNRLKLVP 125

  Fly   313 EGLFAGSKELREIHLQQNELYELPKGLFHRLEQLLVVDLSGNQLTSNHVDNTTFAGLIRLIVLNL 377
            .|:|.|...|.::.:.:|::..|...:|..|..|..:::..|:|.  ::.:..|:||:.|..|.|
Frog   126 LGVFTGLSNLTKLDISENKIVILLDYMFQDLHSLKSLEVGDNELV--YISHRAFSGLVSLEQLTL 188

  Fly   378 AHNALTRIDYRTFKELYFLQILNLRNNSIGHIEDNAFLPLYNLHTLNLAENRLHTLDDKLFNGLY 442
            ....||.:.......|:.|..|:|:..:|..:...||..|::|..|.::...|  ||....|.||
Frog   189 EKCNLTAVPTDALSHLHNLYSLHLKYLNINVLPPFAFKRLFHLKILEISYWPL--LDLVPANSLY 251

  Fly   443 VLSKLTLNNNLISVVEPAVFKNCSDLKELDLSSNQLNEVP-RALQDLAMLRTLDLGENQIRTFDN 506
            .|                      :|..|.:::..|:.:| .||:.|..|..|:|..|.|...|.
Frog   252 GL----------------------NLTFLSITNTNLSTIPYHALKHLIYLTHLNLSYNPIGIIDT 294

  Fly   507 QSFKNLHQLTGLRLIDNQIGNITVGMFQDLPRLSVLNLAKNRIQSIERGSFDKNFELEAIRLDRN 571
            ..|.:|.:|..|.|:..|:..|....||.|..|.:||:::|.::::|..:|.....||.:.:|.|
Frog   295 GVFSDLVRLQELHLVGAQLRTIEPHAFQGLRFLRLLNVSQNLLETLEENAFQSPKALEVLCIDDN 359

  Fly   572 -FLADINGVFATLVSLLWLNLSENHLVWF----DYAFIPSNLKWLDIHGNYIEALGNYYKLQEEI 631
             .:.|..        |:|: |..:.::.|    .....|.:||                    |.
Frog   360 PLVCDCR--------LIWM-LQRHPMLHFGGQQPMCSSPDSLK--------------------ES 395

  Fly   632 RVKTLDAS 639
            ..|.|||:
Frog   396 SYKVLDAA 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-7	NP_523797.1	LRR_8	135..201	CDD:290566
		leucine-rich repeat	136..159	CDD:275380
		leucine-rich repeat	160..190	CDD:275380
		LRR_8	189..259	CDD:290566	5/10 (50%)
		leucine-rich repeat	191..214	CDD:275380
		leucine-rich repeat	215..248	CDD:275380	102/398 (26%)
		LRR_RI	247..501	CDD:238064	67/253 (26%)
		LRR_8	247..308	CDD:290566	18/59 (31%)
		leucine-rich repeat	249..273	CDD:275380	7/23 (30%)
		leucine-rich repeat	274..297	CDD:275380	6/22 (27%)
		LRR_8	297..356	CDD:290566	16/58 (28%)
		leucine-rich repeat	298..321	CDD:275380	9/22 (41%)
		leucine-rich repeat	322..345	CDD:275380	5/22 (23%)
		LRR_8	345..406	CDD:290566	15/60 (25%)
		leucine-rich repeat	346..371	CDD:275380	6/24 (25%)
		leucine-rich repeat	372..395	CDD:275380	6/22 (27%)
		leucine-rich repeat	396..419	CDD:275380	7/22 (32%)
		LRR_8	419..478	CDD:290566	11/58 (19%)
		leucine-rich repeat	420..443	CDD:275380	7/22 (32%)
		leucine-rich repeat	444..467	CDD:275380	1/22 (5%)
		LRR_RI	466..622	CDD:238064	41/161 (25%)
		leucine-rich repeat	468..488	CDD:275380	6/20 (30%)
		LRR_8	491..549	CDD:290566	20/57 (35%)
		leucine-rich repeat	491..514	CDD:275380	8/22 (36%)
		leucine-rich repeat	515..536	CDD:275380	7/20 (35%)
		leucine-rich repeat	539..562	CDD:275380	6/22 (27%)
		leucine-rich repeat	563..585	CDD:275380	5/22 (23%)
		leucine-rich repeat	586..626	CDD:275380	7/43 (16%)
		leucine-rich repeat	627..653	CDD:275380	5/13 (38%)
		LRRCT	716..772	CDD:214507
		LRRNT	796..830	CDD:214470
		leucine-rich repeat	812..829	CDD:275380
		leucine-rich repeat	833..854	CDD:275380
		LRR_8	853..913	CDD:290566
		leucine-rich repeat	855..878	CDD:275380
		LRR_4	878..918	CDD:289563
		leucine-rich repeat	879..902	CDD:275380
		leucine-rich repeat	903..926	CDD:275380
		leucine-rich repeat	927..953	CDD:275380
		TIR	1098..1235	CDD:214587
lingo2	XP_004910881.1	LRRNT	31..64	CDD:214470	1/1 (100%)
		leucine-rich repeat	43..61	CDD:275380
		leucine-rich repeat	63..86	CDD:275380	7/23 (30%)
		internalin_A	<66..>285	CDD:380193	64/245 (26%)
		leucine-rich repeat	87..110	CDD:275380	6/22 (27%)
		leucine-rich repeat	111..134	CDD:275380	9/22 (41%)
		leucine-rich repeat	135..158	CDD:275380	5/22 (23%)
		leucine-rich repeat	159..182	CDD:275380	6/24 (25%)
		leucine-rich repeat	183..206	CDD:275380	6/22 (27%)
		leucine-rich repeat	207..254	CDD:275380	16/70 (23%)
		leucine-rich repeat	255..278	CDD:275380	7/22 (32%)
		LRR_8	279..337	CDD:338972	20/57 (35%)
		leucine-rich repeat	279..302	CDD:275380	8/22 (36%)
		leucine-rich repeat	303..326	CDD:275380	8/22 (36%)
		leucine-rich repeat	327..347	CDD:275380	6/19 (32%)
		TPKR_C2	359..402	CDD:387596	12/71 (17%)
		Ig	429..504	CDD:386229
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100