DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-7 and LOC100485927

DIOPT Version :9

Sequence 1:	NP_523797.1	Gene:	Toll-7 / 37272	FlyBaseID:	FBgn0034476	Length:	1446	Species:	Drosophila melanogaster
Sequence 2:	XP_017946494.1	Gene:	LOC100485927 / 100485927	-ID:	-	Length:	782	Species:	Xenopus tropicalis

Alignment Length:	1013	Identity:	212/1013 - (20%)
Similarity:	356/1013 - (35%)	Gaps:	305/1013 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   284 LSELS-GEALAGLASLRIVNLSNNHLETLPEGLFAGSKELREIHLQQNELYELPKGLFHRLEQLL 347
            ::||| |.......:....:.|:.|.|.:|.|                    ||:
Frog    14 IAELSKGNTDCPCDAAHFCHCSSMHWEAIPSG--------------------LPR---------- 48

  Fly   348 VVDLSGNQLTSNHVDNTTFAGLIRLIVLNLAHNAL---TRIDYRTFKELYFLQILNLRNNSIGHI 409
              |:.|                     |||:.||:   |..|.:.:.:   ||.|.|:.|:|..|
Frog    49 --DVRG---------------------LNLSSNAIQIVTETDLKPYDQ---LQTLLLQYNAIHTI 87

  Fly   410 EDNAFLPLYNLHTLNLAENRLHTLDDKLFNGLYVLSKLT-LNNNLISVVEPAVFKNCSDLKELDL 473
            .|.:|.||.||..|:|:.|.|..|....|..|..|..|. |.|..|::...::|.:.|.|..|..
Frog    88 NDGSFQPLGNLEELDLSYNNLVLLSSVWFRNLNKLKHLNLLGNQYITLGNDSLFASLSSLSSLQF 152

  Fly   474 SSNQLNEVPR-ALQDLAMLRTLDLGENQIRTFDNQSFKNLHQL--TGLRLIDNQIGNITVGMFQD 535
            .:...:.:.: :.:.|..|.||::...|:..::..|...:.|:  |.||:      |:|:
Frog   153 GNQNFDAIQKQSFEGLERLNTLEINAAQLTLYEEGSLGRMKQIYHTILRV------NLTL----- 206

  Fly   536 LPRLSVLNLAKNRIQSIERGSFDKNFELEAIRLDRNFLADINGVFATLVSLLWLNLSENHLVWFD 600
            ||.     |.|:.:.|:..        ||....:.:..||:. .|..|.   :.::.:
Frog   207 LPA-----LLKDLVHSVTL--------LEITDTEFSTPADMQ-AFEVLA---YTSVKQ------- 247

  Fly   601 YAFIPSNLKWLDIHGNYIEALGNYYKLQEEIRVKTLDASHNRITEIGPMSIPNTIELLFINNNLI 665
              ||..|...:|:.|         |:..|.|:      ::..||::           :..|..|:
Frog   248 --FIFRNCTIVDVSG---------YRFVEIIQ------TYRNITDV-----------VMKNCRLL 284

  Fly   666 GNVQPNAFVDKANLARVDLYANQLSKLQLQQLRVAPVVAPKPLPEFYLGGNPFECDCTMDWLQRI 730
            |.     .:|..||.|.             ...|..::                          |
Frog   285 GR-----GLDCPNLKRT-------------TSSVTTII--------------------------I 305

  Fly   731 NNLTTRQHPRVMDMANIECVMPHARGAAV--RPLSGLRPQDFLCRYESHCFALCHCCDFDACDCE 793
            ||:....:....|::::..::|......|  .|:. |.|    |:: |..|......|......:
Frog   306 NNIEVSLYYIFSDLSSLHQIIPQFTYVTVTDSPVY-LIP----CQF-SQSFTSLQYLDVSGGKLD 364

  Fly   794 MTCPSNCTCYHD------QIWSTNVVDCGGQQTTELPRRVPMDSSVVYLDG-----NNFPVLKNH 847
            .|...:..|||:      ::.:.||   .....|.:|:.....|.:.||..     |.|..|...
Frog   365 NTYLGSSVCYHEGGGACPKLQTLNV---SRNLLTSVPKVAQFLSGLNYLTNLDISQNKFSELSTS 426

  Fly   848 AFIGRKNLRALYVNGSQVAAIQNRTFASLASLQLLHLADNKLRTLHGYEFEQLSALRELYLQNNQ 912
            .....|||:.|.::.:|:..|   |.....:||:|.::.|.| |:...|...|:   |||:.||:
Frog   427 KCQWPKNLKYLNISNNQINII---TTCIPPTLQILDVSSNYL-TVFAIEMPNLT---ELYISNNR 484

  Fly   913 LTTI-ENATLAPLAALELIRIDGNRLVTLPIWQMHATHFGTRLKSISLGRNQWSCRCQFLQALTS 976
            |:.: |......|..|.:.|.|.|     ...|.....|..| ..:....|.:.|.||||    .
Frog   485 LSKLPEGMYFTSLVLLSISRNDLN-----GFGQSDLELFSNR-TILDARANNYKCSCQFL----D 539

  Fly   977 YVADNALIVQDAQDIYCMAASSGTGSAALEDSSSNSGSLEKRELDFNATGAACTDYYSGGSMLQH 1041
            ::..|..::....|.|..|:.:......::|:              |.....|           |
Frog   540 FIRSNTAVLVGWPDNYKCASPASVKDVQIQDA--------------NLPPLVC-----------H 579

  Fly  1042 GIPESYIPLLAAALALLFLLVVIAMVFAFRESLRI---------WLFAHYGVRVFGPRCEESEKL 1097
                   ..|...|:.:.|:.::|.:.|....|.:         ||.|.   |.....|:. |..
Frog   580 -------KTLIVTLSCILLIALVAAIVALCHFLHVVWYAKMTWAWLKAK---RKPLKNCDR-EIC 633

  Fly  1098 YDAVLLHSAKDSEFVCQHLAAQLETGRPPLRVCLQHRDLAH-----DATHYQLLEATRVSRRVVI 1157
            :|..:.:|.:|||:|...:..:||.....:::||..||...     |    .:::|...|.:.|.
Frog   634 FDGFVSYSERDSEWVENMMVPKLENATLAMKLCLHKRDFVPGKWIID----NIIDAMEKSYKTVF 694

  Fly  1158 LLTRNFLQTEWARCELRRSVHDALRGRPQKLVIIEEPEVAFEAESDIELL----PYLKTSAVHRI 1218
            :|:.:|:::||.:.||..| |..|                |:..:|..:|    |..|.:...|.
Frog   695 VLSEHFVRSEWCKYELEFS-HFRL----------------FDENNDSAILILLDPIEKETVPKRF 742

  Fly  1219 ------------------RRSDRHFWEKLRYAL-PVDY 1237
                              ......||:.|:.|| |.||
Frog   743 CKLRKLMNTKTYLEWPTDEEQQEVFWDNLKTALQPADY 780

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-7	NP_523797.1	LRR_8	135..201	CDD:290566
		leucine-rich repeat	136..159	CDD:275380
		leucine-rich repeat	160..190	CDD:275380
		LRR_8	189..259	CDD:290566
		leucine-rich repeat	191..214	CDD:275380
		leucine-rich repeat	215..248	CDD:275380
		LRR_RI	247..501	CDD:238064	53/222 (24%)
		LRR_8	247..308	CDD:290566	5/24 (21%)
		leucine-rich repeat	249..273	CDD:275380
		leucine-rich repeat	274..297	CDD:275380	4/13 (31%)
		LRR_8	297..356	CDD:290566	9/58 (16%)
		leucine-rich repeat	298..321	CDD:275380	5/22 (23%)
		leucine-rich repeat	322..345	CDD:275380	2/22 (9%)
		LRR_8	345..406	CDD:290566	14/63 (22%)
		leucine-rich repeat	346..371	CDD:275380	2/24 (8%)
		leucine-rich repeat	372..395	CDD:275380	7/25 (28%)
		leucine-rich repeat	396..419	CDD:275380	11/22 (50%)
		LRR_8	419..478	CDD:290566	18/59 (31%)
		leucine-rich repeat	420..443	CDD:275380	8/22 (36%)
		leucine-rich repeat	444..467	CDD:275380	6/23 (26%)
		LRR_RI	466..622	CDD:238064	31/158 (20%)
		leucine-rich repeat	468..488	CDD:275380	2/20 (10%)
		LRR_8	491..549	CDD:290566	15/59 (25%)
		leucine-rich repeat	491..514	CDD:275380	5/22 (23%)
		leucine-rich repeat	515..536	CDD:275380	5/22 (23%)
		leucine-rich repeat	539..562	CDD:275380	3/22 (14%)
		leucine-rich repeat	563..585	CDD:275380	6/21 (29%)
		leucine-rich repeat	586..626	CDD:275380	5/39 (13%)
		leucine-rich repeat	627..653	CDD:275380	4/25 (16%)
		LRRCT	716..772	CDD:214507	9/57 (16%)
		LRRNT	796..830	CDD:214470	7/39 (18%)
		leucine-rich repeat	812..829	CDD:275380	3/16 (19%)
		leucine-rich repeat	833..854	CDD:275380	5/25 (20%)
		LRR_8	853..913	CDD:290566	20/59 (34%)
		leucine-rich repeat	855..878	CDD:275380	5/22 (23%)
		LRR_4	878..918	CDD:289563	14/40 (35%)
		leucine-rich repeat	879..902	CDD:275380	8/22 (36%)
		leucine-rich repeat	903..926	CDD:275380	8/23 (35%)
		leucine-rich repeat	927..953	CDD:275380	6/25 (24%)
		TIR	1098..1235	CDD:214587	36/164 (22%)
LOC100485927	XP_017946494.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010