DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-7 and lrrn1-like

DIOPT Version :9

Sequence 1:	NP_523797.1	Gene:	Toll-7 / 37272	FlyBaseID:	FBgn0034476	Length:	1446	Species:	Drosophila melanogaster
Sequence 2:	NP_001106456.1	Gene:	lrrn1-like / 100127637	XenbaseID:	XB-GENE-492890	Length:	738	Species:	Xenopus tropicalis

Alignment Length:	647	Identity:	154/647 - (23%)
Similarity:	246/647 - (38%)	Gaps:	150/647 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   248 ELQVLDASHNELRSISESWGISRLRRLQHLNLAYNNLSELSGEALAGLASLRIVNLSNNHLETLP 312
            |.:.:|.:...|..|.|:....    :|.|.|..|.:|.|:.| |..|::|..::||.||.:::.
Frog    58 EAKTVDCNDLLLTHIPENLSTD----IQVLLLQSNKISHLTWE-LQELSNLTELDLSQNHFQSID 117

  Fly   313 EGLFAGSKELREIHLQQNELYELPKGLFHRLEQLLVVDLSGNQLTSNHVDNTTFAGLIRLIVLNL 377
            :...:...:|..::|::|:|.|||......|..|..:.::.||:  :::....|:||.||:.|:|
Frog   118 DLGVSNLSQLITLYLEENQLRELPDYSLKDLGSLEELYINHNQI--SYIGPRAFSGLGRLLRLHL 180

  Fly   378 AHNALTRIDYRTFKELYFLQILNLRNNSIGHIEDNAFLPLYNLHTLNLAENRLHTLDDKLFNGLY 442
            ..|.|..||.|.|::|..|:||.:..|.:..::...|.||..||:|.||...|..:.:..|.||.
Frog   181 NANRLEIIDPRWFEDLPNLEILMVGENPVTALQSLNFQPLGRLHSLVLAGMELEHIPENAFQGLD 245

  Fly   443 VLSKLTLNNNLISVVEPAVFKNCSDLKELDLSSNQLNEV-------------------------- 481
            .|..|:..:|.::.|.....||...||.|||:.|.:.|:
Frog   246 YLESLSFFDNRLTEVPKEALKNLKLLKFLDLNKNPIPEIRGGDFTGMEHLEELSLNSMEELERVE 310

  Fly   482 PRALQDLAMLRTLDLGEN-QIRTFDNQSF-KNLHQLTGLRLIDNQIGNITVGMFQDLPRLSVLNL 544
            ..|.|||..|..|::..| ::...|.::| .||..|..|.|.:|::..:.:.:||.||.|..::|
Frog   311 AEAFQDLPELIKLEMCNNPRLSYLDPEAFSSNLGALKTLLLNNNRLAMVPLKIFQALPGLLEISL 375

  Fly   545 AKNRIQSIERGSFDKNFELEAIRLDRNFLAD---ING-VFATLVSLLWLN----LSENHLV--WF 599
            ..|.|:...:..:....:|..|........:   ::| :|..:....|||    |.:.||:  .|
Frog   376 YSNPIRCDCQNCWKGLSKLRLIEAQATLCINPPLVSGHLFQEIQGQAWLNRCPPLIDTHLIPPQF 440

  Fly   600 DYA-FIPSNLK------------WLDIHGNYIEALGNYYKLQEEIRVKTLDA------------- 638
            ..| ..|..|.            |:..||..:.......|:.....::..||
Frog   441 QIARHQPVKLSCQASGHPKPEIYWMTPHGERVTGTNGRVKINAGGSLEITDAVEEDSGSYTCQMW 505

  Fly   639 ------------SHNRITEIGPMSIPNTIELLFINNNLIGN-------------VQPNAFV---- 674
                        |.||..|      |..:.||.:...:..|             |.||..|
Frog   506 NSDGTDSKSVFVSINRTQE------PEAMSLLMVTKKVHSNFAVVEWKMLSGSGVSPNVLVPFQW 564

  Fly   675 DKANL----------ARVDLYANQLSKLQLQQ-------LRVAPVVAPKPLPEFYLGGNPFECDC 722
            ..|.:          |:|.|...:.:...||.       |.|:.|..|..
Frog   565 SSATMRIHNPHISYTAKVPLEVQEYNLTHLQPSTKYEVCLTVSSVSQPSQ--------------- 614

  Fly   723 TMDWLQRINNLTTRQHPRVMDMANIECVMPHARGAAVRPLSGLRPQDFLCRYESHCFALCHC 784
                 |...|:|||.  ....||.:...:..|..||:..|...     ||......:..|||
Frog   615 -----QSCLNITTRD--ASFSMAVVGRPVSIALSAALGSLVAA-----LCMAALIIYIGCHC 664

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-7	NP_523797.1	LRR_8	135..201	CDD:290566
		leucine-rich repeat	136..159	CDD:275380
		leucine-rich repeat	160..190	CDD:275380
		LRR_8	189..259	CDD:290566	2/10 (20%)
		leucine-rich repeat	191..214	CDD:275380
		leucine-rich repeat	215..248	CDD:275380	154/647 (24%)
		LRR_RI	247..501	CDD:238064	80/279 (29%)
		LRR_8	247..308	CDD:290566	18/59 (31%)
		leucine-rich repeat	249..273	CDD:275380	4/23 (17%)
		leucine-rich repeat	274..297	CDD:275380	9/22 (41%)
		LRR_8	297..356	CDD:290566	15/58 (26%)
		leucine-rich repeat	298..321	CDD:275380	5/22 (23%)
		leucine-rich repeat	322..345	CDD:275380	8/22 (36%)
		LRR_8	345..406	CDD:290566	21/60 (35%)
		leucine-rich repeat	346..371	CDD:275380	6/24 (25%)
		leucine-rich repeat	372..395	CDD:275380	10/22 (45%)
		leucine-rich repeat	396..419	CDD:275380	7/22 (32%)
		LRR_8	419..478	CDD:290566	21/58 (36%)
		leucine-rich repeat	420..443	CDD:275380	9/22 (41%)
		leucine-rich repeat	444..467	CDD:275380	6/22 (27%)
		LRR_RI	466..622	CDD:238064	47/206 (23%)
		leucine-rich repeat	468..488	CDD:275380	9/45 (20%)
		LRR_8	491..549	CDD:290566	18/59 (31%)
		leucine-rich repeat	491..514	CDD:275380	7/24 (29%)
		leucine-rich repeat	515..536	CDD:275380	6/20 (30%)
		leucine-rich repeat	539..562	CDD:275380	4/22 (18%)
		leucine-rich repeat	563..585	CDD:275380	4/25 (16%)
		leucine-rich repeat	586..626	CDD:275380	13/58 (22%)
		leucine-rich repeat	627..653	CDD:275380	6/50 (12%)
		LRRCT	716..772	CDD:214507	11/55 (20%)
		LRRNT	796..830	CDD:214470
		leucine-rich repeat	812..829	CDD:275380
		leucine-rich repeat	833..854	CDD:275380
		LRR_8	853..913	CDD:290566
		leucine-rich repeat	855..878	CDD:275380
		LRR_4	878..918	CDD:289563
		leucine-rich repeat	879..902	CDD:275380
		leucine-rich repeat	903..926	CDD:275380
		leucine-rich repeat	927..953	CDD:275380
		TIR	1098..1235	CDD:214587
lrrn1-like	NP_001106456.1	NEL	<52..>262	CDD:330839	64/210 (30%)
		leucine-rich repeat	60..79	CDD:275380	4/18 (22%)
		leucine-rich repeat	80..102	CDD:275380	9/22 (41%)
		LRR_8	101..161	CDD:316378	15/59 (25%)
		leucine-rich repeat	103..126	CDD:275380	5/22 (23%)
		leucine-rich repeat	127..150	CDD:275380	8/22 (36%)
		leucine-rich repeat	151..174	CDD:275380	6/24 (25%)
		leucine-rich repeat	175..198	CDD:275380	10/22 (45%)
		leucine-rich repeat	199..222	CDD:275380	7/22 (32%)
		leucine-rich repeat	223..246	CDD:275380	9/22 (41%)
		leucine-rich repeat	247..294	CDD:275380	13/46 (28%)
		LRR_8	294..356	CDD:316378	15/61 (25%)
		leucine-rich repeat	295..319	CDD:275380	4/23 (17%)
		leucine-rich repeat	320..345	CDD:275380	7/24 (29%)
		leucine-rich repeat	346..367	CDD:275380	6/20 (30%)
		PCC	351..>412	CDD:188093	12/60 (20%)
		leucine-rich repeat	370..382	CDD:275378	4/11 (36%)
		Ig	448..515	CDD:319273	7/66 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910