DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Toll-7 and lingo1

DIOPT Version :9

Sequence 1:	NP_523797.1	Gene:	Toll-7 / 37272	FlyBaseID:	FBgn0034476	Length:	1446	Species:	Drosophila melanogaster
Sequence 2:	NP_001093719.1	Gene:	lingo1 / 100101739	XenbaseID:	XB-GENE-921957	Length:	606	Species:	Xenopus tropicalis

Alignment Length:	406	Identity:	108/406 - (26%)
Similarity:	177/406 - (43%)	Gaps:	62/406 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   203 QLPSGFLCPVGNLQVLNL---------------TRNRIRTAEQMGFADMNCGAGSGSAGSELQVL 252
            |||| .|||:..:.|.::               .::|.....:..:.|:..|     ..::.::|
Frog     4 QLPS-CLCPILLIVVGSILSGSASGCPQRCDCSPQDRSVLCHRKRYLDVPEG-----IPTDTRLL 62

  Fly   253 DASHNELRSISESWGISRLRRLQHLNLAYNNLSELSGEALAGLASLRIVNLSNNHLETLPEGLFA 317
            |.|.|.::::::. ..|....|:.|.|..|.:|.:...|..||.:||.:.|.:|.|:.:|.|:|.
Frog    63 DLSKNRIKALNQD-EFSAFPYLEELELNENIVSIIEPGAFNGLFNLRSLGLRSNRLKLIPLGVFT 126

  Fly   318 GSKELREIHLQQNELYELPKGLFHRLEQLLVVDLSGNQLTSNHVDNTTFAGLIRLIVLNLAHNAL 382
            |...|.::.:.:|::..|...:|..|..|..:::..|.|.  ::.:..|.||..|..|.|....|
Frog   127 GLSNLTQLDISENKIVILLDDMFQDLYNLKSLEVGDNDLV--YISHRAFRGLNSLEELTLEKCNL 189

  Fly   383 TRIDYRTFKELYFLQILNLRNNSIGHIEDNAFLPLYNLHTLNLAENRLH--TLDDKLFNGLYVLS 445
            |.:.......|:.|..|.||..:|..|.|.:|..||.|..|.:|    |  .||....||||.|
Frog   190 TSVPTEALSHLHGLITLKLRYLNINVIRDYSFKRLYRLKNLEIA----HWPYLDTMTSNGLYGL- 249

  Fly   446 KLTLNNNLISVVEPAVFKNCSDLKELDLSSNQLNEVPR-ALQDLAMLRTLDLGENQIRTFDNQSF 509
                                 :|..|.::.:.|:.:|. |::.|..||.|:|..|.|...:....
Frog   250 ---------------------NLTSLSITHSNLSSIPYVAIRHLVYLRFLNLSYNPITAVEGSML 293

  Fly   510 KNLHQLTGLRLIDNQIGNITVGMFQDLPRLSVLNLAKNRIQSIERGSFDKNFELEAIRLDRNFLA 574
            ..|.:|....|:..|:..:....|:.|..|.|||::.|.:.::|..||.....||.:.||:|.||
Frog   294 YELLRLQEFHLVGGQLSVVEPYAFRGLNHLKVLNVSSNYLSTLEESSFHSVGNLETLILDKNPLA 358

  Fly   575 -DINGVFATLVSLLWL 589
             |..        |||:
Frog   359 CDCR--------LLWI 366

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-7	NP_523797.1	LRR_8	135..201	CDD:290566
		leucine-rich repeat	136..159	CDD:275380
		leucine-rich repeat	160..190	CDD:275380
		LRR_8	189..259	CDD:290566	15/70 (21%)
		leucine-rich repeat	191..214	CDD:275380	7/10 (70%)
		leucine-rich repeat	215..248	CDD:275380	4/47 (9%)
		LRR_RI	247..501	CDD:238064	71/256 (28%)
		LRR_8	247..308	CDD:290566	17/60 (28%)
		leucine-rich repeat	249..273	CDD:275380	5/23 (22%)
		leucine-rich repeat	274..297	CDD:275380	8/22 (36%)
		LRR_8	297..356	CDD:290566	16/58 (28%)
		leucine-rich repeat	298..321	CDD:275380	9/22 (41%)
		leucine-rich repeat	322..345	CDD:275380	5/22 (23%)
		LRR_8	345..406	CDD:290566	16/60 (27%)
		leucine-rich repeat	346..371	CDD:275380	6/24 (25%)
		leucine-rich repeat	372..395	CDD:275380	6/22 (27%)
		leucine-rich repeat	396..419	CDD:275380	9/22 (41%)
		LRR_8	419..478	CDD:290566	13/60 (22%)
		leucine-rich repeat	420..443	CDD:275380	9/24 (38%)
		leucine-rich repeat	444..467	CDD:275380	1/22 (5%)
		LRR_RI	466..622	CDD:238064	37/126 (29%)
		leucine-rich repeat	468..488	CDD:275380	5/20 (25%)
		LRR_8	491..549	CDD:290566	17/57 (30%)
		leucine-rich repeat	491..514	CDD:275380	7/22 (32%)
		leucine-rich repeat	515..536	CDD:275380	4/20 (20%)
		leucine-rich repeat	539..562	CDD:275380	8/22 (36%)
		leucine-rich repeat	563..585	CDD:275380	8/22 (36%)
		leucine-rich repeat	586..626	CDD:275380	3/4 (75%)
		leucine-rich repeat	627..653	CDD:275380
		LRRCT	716..772	CDD:214507
		LRRNT	796..830	CDD:214470
		leucine-rich repeat	812..829	CDD:275380
		leucine-rich repeat	833..854	CDD:275380
		LRR_8	853..913	CDD:290566
		leucine-rich repeat	855..878	CDD:275380
		LRR_4	878..918	CDD:289563
		leucine-rich repeat	879..902	CDD:275380
		leucine-rich repeat	903..926	CDD:275380
		leucine-rich repeat	927..953	CDD:275380
		TIR	1098..1235	CDD:214587
lingo1	NP_001093719.1	LRRNT	27..61	CDD:214470	3/38 (8%)
		LRR 1	58..79		4/21 (19%)
		leucine-rich repeat	59..82	CDD:275380	5/23 (22%)
		PLN00113	62..>381	CDD:215061	97/342 (28%)
		LRR 2	82..103		6/20 (30%)
		leucine-rich repeat	83..106	CDD:275380	8/22 (36%)
		LRR_8	106..165	CDD:338972	16/58 (28%)
		LRR 3	106..127		8/20 (40%)
		leucine-rich repeat	107..130	CDD:275380	9/22 (41%)
		LRR 4	130..151		4/20 (20%)
		leucine-rich repeat	131..154	CDD:275380	5/22 (23%)
		LRR 5	154..175		4/22 (18%)
		leucine-rich repeat	155..178	CDD:275380	6/24 (25%)
		LRR 6	178..199		5/20 (25%)
		leucine-rich repeat	179..250	CDD:275380	27/96 (28%)
		LRR 7	202..223		8/20 (40%)
		leucine-rich repeat	203..226	CDD:275380	9/22 (41%)
		LRR 8	250..271		5/20 (25%)
		leucine-rich repeat	251..274	CDD:275380	6/22 (27%)
		LRR 9	274..295		6/20 (30%)
		leucine-rich repeat	275..298	CDD:275380	7/22 (32%)
		LRR 10	298..319		4/20 (20%)
		leucine-rich repeat	299..322	CDD:275380	5/22 (23%)
		LRR 11	322..343		8/20 (40%)
		leucine-rich repeat	323..343	CDD:275380	8/19 (42%)
		Ig	425..500	CDD:386229
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010