DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-7 and tlr20.4

DIOPT Version :9

Sequence 1:	NP_523797.1	Gene:	Toll-7 / 37272	FlyBaseID:	FBgn0034476	Length:	1446	Species:	Drosophila melanogaster
Sequence 2:	XP_009303038.2	Gene:	tlr20.4 / 100005571	ZFINID:	ZDB-GENE-071002-1	Length:	951	Species:	Danio rerio

Alignment Length:	1239	Identity:	263/1239 - (21%)
Similarity:	431/1239 - (34%)	Gaps:	430/1239 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 CSWSYNGTSSVHCALRLIERQPGL--DLQGA----DGSSQLTIQCSELYLFESTLPVAVFARLQT 135
            |..:.||....| ...:.|...||  .||..    ||.|            :..|....|:...:
Zfish    47 CPGNINGADCKH-VTDIKEDLRGLPSSLQSVCIQMDGGS------------DGVLAPNSFSSFAS 98

  Fly   136 LEALRLDSCKLLQLPNNAFEGLATLKSLRLSTHNSEWGPTRTLELFPDSLGGLKQLTDLDLGDNN 200
            |:.|.:..| ..|:|..||.||..:.||.:|:.|||    :..|:..|
Zfish    99 LKQLTIAGC-FSQIPPEAFNGLTNVTSLSISSSNSE----KCCEVALD----------------- 141

  Fly   201 LRQLPSGFLCPVGNLQVLNLTRNRIRTAEQMGFADMNCGAGSGSAGSELQVLDASHNELRSISES 265
            ..:|||             |||..|      .:.|::.        .:|.|.|.
Zfish   142 FSRLPS-------------LTRLFI------SYYDLSL--------FKLNVFDK----------- 168

  Fly   266 WGISRLRRLQHLNLAYNNLSELSGEALAGLASLRIVNLSNNHLETLPEGLFAGSKELREIHLQQN 330
              |..|..|...|:..||:||:    |..||::                     |.|::.:|.
Zfish   169 --IPHLEELHLGNVCLNNISEV----LCRLANV---------------------KSLKQFNLD-- 204

  Fly   331 ELYELPKGLFHRLEQLLVVDLSGNQLTSN-HVDNTT-FAGLIRLIVLNLAHNALTRIDY------ 387
                   |:.|:|:.            || .|.||: .:....:..:||   .||::::
Zfish   205 -------GVLHKLQH------------SNCSVFNTSNISTEFNIEKVNL---TLTKVEHVDEGAL 247

  Fly   388 RTFKELYFLQILNLRNNSIGH---IEDNAFLPLYNLHTLNLAENRLHTLDDKLFNGLYVLSKLTL 449
            :||.:|:|.|..      :.|   :.|.:.:.::.:.||:...:.|:..|..:...||.:.::.:
Zfish   248 KTFGKLFFFQFF------VSHTDFLRDLSLIGVHKIRTLDFKVDVLNVDDLCVAAKLYSVERMFV 306

  Fly   450 NNNLISV-VEPAVFKNCSDLKELDLSSNQLNEVPRALQDLAMLRTLDLGENQIRTFDNQSFKNLH 513
            :..:|:: |.|.   |.||..|..:|....|::...:.||..:.:|           .|.|.||.
Zfish   307 SYEMINLSVTPT---NMSDGCEYIMSIALSNDISVKIVDLLDVYSL-----------FQIFSNLT 357

  Fly   514 QLTGLR---LIDNQIGNITVGMFQDLPRLSVLNLAKNRIQSIERGSFDKNFELEAIRLDRNFLAD 575
            .:| ::   |..|...::.....|.:.:|||:.|..|||..|
Zfish   358 TVT-IQYHILRSNDFLSLCASFPQAVKQLSVMILKNNRIDKI----------------------- 398

  Fly   576 INGVFATLVSLLWLNLSENHL-VWFDYAFIPSN-LKWLDIHGNYIEALGNY-YKLQEEIRVKTLD 637
            ::..|...|:|..|.|..:.: |:.|:|||..| ||.|::|.|.|.::..: :....|:||  ||
Zfish   399 VSHQFMCFVNLKTLKLVMSKISVFEDFAFIGLNKLKELNLHSNKISSIHRHTFSGLHELRV--LD 461

  Fly   638 ASHNRITEIGPMSIPNTIELLFINNNLIG--NVQPNAFVDKANLARVDLYANQLSKLQLQQLRVA 700
            ...|.|..|.|.|..:...|   ::.|:|  |..||.               .|.||.|..:
Zfish   462 LQENPIIYIEPKSFGHFTNL---SSLLLGDLNFPPNM---------------SLIKLHLSDI--- 505

  Fly   701 PVVAPKPLPEFYLGGNPFECDCTMDWLQRINNLTTRQHPRVMDMANIECVMPHARGAAVRPLSGL 765
                        .||.|             :||:.                       |...|||
Zfish   506 ------------FGGIP-------------SNLSN-----------------------VFISSGL 522

  Fly   766 RPQDFLCRYESHCFALCHCCDFDACDCEMTCPSNCTC-----YHDQIWSTNVVDCGGQQTTELPR 825
            ||.                        .:...||.|.     .|.:.....|.||.....|
Zfish   523 RPM------------------------HLVIGSNTTLNNGLNLHIKGQYVIVEDCNSLLLT---- 559

  Fly   826 RVPMDSSVVYLDGNNFPVLKNHAFIGRKNLRALYVNGSQVAAIQNRTFASLASL----QLLHLAD 886
                  |||.|......::..:.|||:      ||........|:....::..|    ||:||..
Zfish   560 ------SVVTLQIQAAYMICENEFIGK------YVPSVVSLEFQSMFADNIGDLSVINQLVHLKT 612

  Fly   887 NKLRTLH-------GYEFEQLSALRELYLQNNQLTTIENATLAPLAAL-ELIRIDGNRLVTLPIW 943
            .||..:.       |..|..|:.|.::.|.|.::..::.:....|.|| .|:.|....:..:..:
Zfish   613 LKLENIDLTNQPNTGIMFHNLTKLEKMILMNCKIFFLDKSVTKDLKALTSLVLIPKEAVNIIQNF 677

  Fly   944 QMHATHFGTRLKSISLGRNQWSCRCQFLQALTSYVADNALIV-----QDAQDIYCMAASSGTGSA 1003
            ....||    ||.:........|.|.... |.|::.||..:.     ...:|:.|:....
Zfish   678 MEQPTH----LKYLHFQCLDLYCSCDNTW-LVSWIRDNGKVEVVMSNPSMEDLRCLTDDE----- 732

  Fly  1004 ALEDSSSNSGSLEKRELDFNATGAACTDYYSGGSMLQHGIPESYIPLLAAALALLFLLVVIAMVF 1068
             ::..:..|.:.|...:|.:....:|:..:                      ..:|::||:...|
Zfish   733 -VDHLNFISYAKENCSIDLDFVFFSCSSVF----------------------LCIFIVVVLMYKF 774

  Fly  1069 A--------------FRESLRIWLFAHYGVRVFGPRCEESEKLYDAVLLHSAKDSEFVCQHLAAQ 1119
            .              |||:||:              .|:.:..|||.:.:|.||..:|.:.|...
Zfish   775 VGQYFKPFYHIASGWFREALRM--------------KEKQQYRYDAFVSYSGKDEHWVIEELLPN 825

  Fly  1120 LETGRPP-LRVCLQHRD--LAHDATHYQLLEATRVSRRVVILLTRNFLQTEWARCELRRSVHDAL 1181
            ||...|| ||:||..||  |.||... .:.::...|||.:.|::||:|.:.|...|::.:.:
Zfish   826 LEQRGPPFLRLCLHSRDFQLGHDIVE-NITDSIYASRRTLCLVSRNYLNSNWCSVEMQLATY--- 886

  Fly  1182 RGRPQKLVIIEEPEVAFEAESDIELLPYLKT------SAVHRIRR-------------SDRH--F 1225
                 :|.:         ...||.:|.:|:|      |:.||:.|             .:.|  |
Zfish   887 -----RLQV---------EHRDILILVFLETIPSRLLSSHHRLARLVKTRTYLDWPQEPEMHEAF 937

  Fly  1226 WEKL 1229
            |::|
Zfish   938 WDRL 941

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-7	NP_523797.1	LRR_8	135..201	CDD:290566	17/65 (26%)
		leucine-rich repeat	136..159	CDD:275380	9/22 (41%)
		leucine-rich repeat	160..190	CDD:275380	8/29 (28%)
		LRR_8	189..259	CDD:290566	11/69 (16%)
		leucine-rich repeat	191..214	CDD:275380	3/22 (14%)
		leucine-rich repeat	215..248	CDD:275380	5/32 (16%)
		LRR_RI	247..501	CDD:238064	54/265 (20%)
		LRR_8	247..308	CDD:290566	14/60 (23%)
		leucine-rich repeat	249..273	CDD:275380	5/23 (22%)
		leucine-rich repeat	274..297	CDD:275380	8/22 (36%)
		LRR_8	297..356	CDD:290566	6/58 (10%)
		leucine-rich repeat	298..321	CDD:275380	0/22 (0%)
		leucine-rich repeat	322..345	CDD:275380	5/22 (23%)
		LRR_8	345..406	CDD:290566	14/68 (21%)
		leucine-rich repeat	346..371	CDD:275380	5/26 (19%)
		leucine-rich repeat	372..395	CDD:275380	7/28 (25%)
		leucine-rich repeat	396..419	CDD:275380	3/25 (12%)
		LRR_8	419..478	CDD:290566	14/59 (24%)
		leucine-rich repeat	420..443	CDD:275380	5/22 (23%)
		leucine-rich repeat	444..467	CDD:275380	4/23 (17%)
		LRR_RI	466..622	CDD:238064	41/160 (26%)
		leucine-rich repeat	468..488	CDD:275380	3/19 (16%)
		LRR_8	491..549	CDD:290566	14/60 (23%)
		leucine-rich repeat	491..514	CDD:275380	5/22 (23%)
		leucine-rich repeat	515..536	CDD:275380	4/23 (17%)
		leucine-rich repeat	539..562	CDD:275380	8/22 (36%)
		leucine-rich repeat	563..585	CDD:275380	1/21 (5%)
		leucine-rich repeat	586..626	CDD:275380	15/42 (36%)
		leucine-rich repeat	627..653	CDD:275380	10/25 (40%)
		LRRCT	716..772	CDD:214507	9/55 (16%)
		LRRNT	796..830	CDD:214470	8/38 (21%)
		leucine-rich repeat	812..829	CDD:275380	4/16 (25%)
		leucine-rich repeat	833..854	CDD:275380	6/20 (30%)
		LRR_8	853..913	CDD:290566	16/70 (23%)
		leucine-rich repeat	855..878	CDD:275380	3/22 (14%)
		LRR_4	878..918	CDD:289563	13/50 (26%)
		leucine-rich repeat	879..902	CDD:275380	10/33 (30%)
		leucine-rich repeat	903..926	CDD:275380	4/22 (18%)
		leucine-rich repeat	927..953	CDD:275380	5/26 (19%)
		TIR	1098..1235	CDD:214587	44/156 (28%)
tlr20.4	XP_009303038.2	leucine-rich repeat	99..121	CDD:275380	9/22 (41%)
		leucine-rich repeat	148..171	CDD:275380	9/49 (18%)
		leucine-rich repeat	172..197	CDD:275380	10/49 (20%)
		leucine-rich repeat	229..265	CDD:275380	10/44 (23%)
		leucine-rich repeat	385..408	CDD:275378	9/45 (20%)
		LRR_8	408..467	CDD:316378	21/60 (35%)
		leucine-rich repeat	409..432	CDD:275378	8/22 (36%)
		PLN00113	<427..>516	CDD:331614	34/159 (21%)
		leucine-rich repeat	433..456	CDD:275378	6/22 (27%)
		leucine-rich repeat	457..480	CDD:275378	9/24 (38%)
		leucine-rich repeat	541..584	CDD:275380	14/58 (24%)
		leucine-rich repeat	585..609	CDD:275380	4/23 (17%)
		leucine-rich repeat	610..635	CDD:275380	6/24 (25%)
		leucine-rich repeat	636..659	CDD:275380	4/22 (18%)
		TIR	803..941	CDD:214587	43/155 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920