DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-7 and lingo4a

DIOPT Version :9

Sequence 1:	NP_523797.1	Gene:	Toll-7 / 37272	FlyBaseID:	FBgn0034476	Length:	1446	Species:	Drosophila melanogaster
Sequence 2:	NP_001076447.1	Gene:	lingo4a / 100005227	ZFINID:	ZDB-GENE-060503-275	Length:	618	Species:	Danio rerio

Alignment Length:	424	Identity:	118/424 - (27%)
Similarity:	191/424 - (45%)	Gaps:	52/424 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   236 MNCGAGSGSAGSE-----LQVLDASHNELRSISESWGISRLRRLQHLNLAYNNLSELSGEALAGL 295
            ::|.:...||..|     .|||:.::|.|:::|.....| ||:|:.|:|:.|.|:.:..||..||
Zfish    55 VDCSSQQLSAVPEGVPDATQVLNLTYNHLKTLSSRQFFS-LRQLRELDLSANMLTVIEVEAFVGL 118

  Fly   296 ASLRIVNLSNNHLETLPEGLFAGSKELREIHLQQNELYELPKGLFHRLEQLLVVDLSGNQLTSNH 360
            .:|..:.||.|.|:.:|.|.|:|...::.:.:.:||:..|...:|..:..|..::.|.|.|.  .
Zfish   119 QNLITLRLSRNRLKIIPVGAFSGLPNVQFLDISENEILVLLDDMFGEMPSLQKLEASENDLV--F 181

  Fly   361 VDNTTFAGLIRLIVLNLAHNALTRIDYRTFKELYFLQILNLRNNSIGHIEDNAFLPLYNLHTLNL 425
            :.|..|:||..|:.|.|....||.:....|..|..||.|......:..:.:|:|..|..|..|::
Zfish   182 ISNRAFSGLPNLLELRLERCNLTTVPSEAFSRLTGLQHLRFCRLGLTALPNNSFRQLQRLQDLHV 246

  Fly   426 AE-NRLHTLDDKLFNGLYVLSKLTLNNNLISVVEPAVFKNCSDLKELDLSSNQLNEVPRA-LQDL 488
            :. ..||||               ..|:||.:          :|..|.||...|:.||.| |..|
Zfish   247 SRCPWLHTL---------------AVNSLIGL----------NLTSLTLSHCNLSAVPYAPLHHL 286

  Fly   489 AMLRTLDLGENQIRTFDNQSFKNLHQLTGLRLIDNQIGNITVGMFQDLPRLSVLNLAKNRIQSIE 553
            ..||.|||..|.|.|..:....:|.:|..|.|:...:.::..|.|::|....:||::.||:.::|
Zfish   287 VYLRYLDLSYNPITTVLSGLLGDLLRLQELHLVSTGLLHVESGAFRNLAFFRLLNVSDNRLVTLE 351

  Fly   554 RGSFDKNFELEAIRLDRNFLA-DINGVFATLVSLLWLNLSENHLVWFDYAFIPSNLKWLDIHGNY 617
            ..:|.....||.:|||.|.|| |..        |||:......|.:..:|  ||.:..:.:.|..
Zfish   352 ESAFHAVGSLEVLRLDGNPLACDCR--------LLWVMRRRLRLRFAGHA--PSCVSPVQVQGRM 406

  Fly   618 IEALGNYYKLQEEIRVKTLDASHNRITEIGPMSI 651
            .:...     :.|: .:|......||....|..:
Zfish   407 FQDFA-----ESEV-ARTFTCRQARILTRKPQDV 434

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-7	NP_523797.1	LRR_8	135..201	CDD:290566
		leucine-rich repeat	136..159	CDD:275380
		leucine-rich repeat	160..190	CDD:275380
		LRR_8	189..259	CDD:290566	8/27 (30%)
		leucine-rich repeat	191..214	CDD:275380
		leucine-rich repeat	215..248	CDD:275380	3/11 (27%)
		LRR_RI	247..501	CDD:238064	78/260 (30%)
		LRR_8	247..308	CDD:290566	23/65 (35%)
		leucine-rich repeat	249..273	CDD:275380	8/23 (35%)
		leucine-rich repeat	274..297	CDD:275380	9/22 (41%)
		LRR_8	297..356	CDD:290566	16/58 (28%)
		leucine-rich repeat	298..321	CDD:275380	9/22 (41%)
		leucine-rich repeat	322..345	CDD:275380	4/22 (18%)
		LRR_8	345..406	CDD:290566	18/60 (30%)
		leucine-rich repeat	346..371	CDD:275380	8/24 (33%)
		leucine-rich repeat	372..395	CDD:275380	7/22 (32%)
		leucine-rich repeat	396..419	CDD:275380	6/22 (27%)
		LRR_8	419..478	CDD:290566	13/59 (22%)
		leucine-rich repeat	420..443	CDD:275380	6/23 (26%)
		leucine-rich repeat	444..467	CDD:275380	3/22 (14%)
		LRR_RI	466..622	CDD:238064	48/157 (31%)
		leucine-rich repeat	468..488	CDD:275380	9/20 (45%)
		LRR_8	491..549	CDD:290566	18/57 (32%)
		leucine-rich repeat	491..514	CDD:275380	9/22 (41%)
		leucine-rich repeat	515..536	CDD:275380	5/20 (25%)
		leucine-rich repeat	539..562	CDD:275380	6/22 (27%)
		leucine-rich repeat	563..585	CDD:275380	9/22 (41%)
		leucine-rich repeat	586..626	CDD:275380	8/39 (21%)
		leucine-rich repeat	627..653	CDD:275380	5/25 (20%)
		LRRCT	716..772	CDD:214507
		LRRNT	796..830	CDD:214470
		leucine-rich repeat	812..829	CDD:275380
		leucine-rich repeat	833..854	CDD:275380
		LRR_8	853..913	CDD:290566
		leucine-rich repeat	855..878	CDD:275380
		LRR_4	878..918	CDD:289563
		leucine-rich repeat	879..902	CDD:275380
		leucine-rich repeat	903..926	CDD:275380
		leucine-rich repeat	927..953	CDD:275380
		TIR	1098..1235	CDD:214587
lingo4a	NP_001076447.1	LRRNT	41..70	CDD:214470	4/14 (29%)
		leucine-rich repeat	52..72	CDD:275380	4/16 (25%)
		leucine-rich repeat	73..96	CDD:275380	8/23 (35%)
		LRR_RI	88..380	CDD:238064	97/327 (30%)
		LRR_8	95..155	CDD:290566	20/59 (34%)
		leucine-rich repeat	97..120	CDD:275380	9/22 (41%)
		leucine-rich repeat	121..144	CDD:275380	9/22 (41%)
		leucine-rich repeat	145..168	CDD:275380	4/22 (18%)
		leucine-rich repeat	169..192	CDD:275380	8/24 (33%)
		LRR_8	191..250	CDD:290566	15/58 (26%)
		leucine-rich repeat	193..216	CDD:275380	7/22 (32%)
		leucine-rich repeat	217..240	CDD:275380	6/22 (27%)
		leucine-rich repeat	241..288	CDD:275380	19/71 (27%)
		LRR_8	264..323	CDD:290566	22/58 (38%)
		leucine-rich repeat	289..310	CDD:275380	8/20 (40%)
		LRR_8	312..371	CDD:290566	18/58 (31%)
		leucine-rich repeat	313..336	CDD:275380	6/22 (27%)
		leucine-rich repeat	337..356	CDD:275380	5/18 (28%)
		I-set	428..512	CDD:254352	1/7 (14%)
		Ig	439..512	CDD:299845
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100