DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-7 and lrrtm4l1

DIOPT Version :9

Sequence 1:	NP_523797.1	Gene:	Toll-7 / 37272	FlyBaseID:	FBgn0034476	Length:	1446	Species:	Drosophila melanogaster
Sequence 2:	NP_001373591.1	Gene:	lrrtm4l1 / 100000724	ZFINID:	ZDB-GENE-080327-15	Length:	571	Species:	Danio rerio

Alignment Length:	501	Identity:	120/501 - (23%)
Similarity:	194/501 - (38%)	Gaps:	147/501 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 SVHCALRLIERQPGLDLQGADGSSQLTIQCSELYLFESTLPVAVFARLQTLEALRLDSC----KL 146
            |:.|.:||    .||          |.:|.|.|.||.|.            |.:...||    |:
Zfish     3 SLACDMRL----AGL----------LLLQASSLLLFSSG------------ERMCPYSCHCEGKI 41

  Fly   147 LQLPNNAFEGLATLKSLRLSTHNSEWGPTRTLELFPDSLGGLKQLTDLDLGDNNLRQLPSGFLCP 211
            :...::||:.:                        |:::.
Zfish    42 VHCESSAFQDV------------------------PENIS------------------------- 57

  Fly   212 VGNLQVLNLTRNRIRTAEQMGFADMNCGAGSGSAGSELQVLDASHNELRSISESWGISRLRRLQH 276
             .:.|.|:|..|.:.|.....||.:|          :|..|...||::..: :|.....:|||:.
Zfish    58 -VSCQGLSLRYNDLHTMLPYQFAHLN----------QLLWLYLDHNQIMFV-DSRAFQGVRRLKE 110

  Fly   277 LNLAYNNLSELSGEALAGLASLRIVNLSNNHLETLPEGLFAGSKELREIHLQQNELYELPKGLFH 341
            |.|:.|.:|:|......|:.:||.::||.|.|:.|..|.|.|.::|:.:||:.|.|..:|...|.
Zfish   111 LILSSNRISQLHNVTFHGVPNLRSLDLSYNKLQELQPGQFYGLRKLQNLHLRSNGLTAIPVRAFL 175

  Fly   342 RLEQLLVVDLSGNQLTSNHVDNTTFAGLIRLIVLNLAHNALTRIDYRTFKELYFLQILNLRNNSI 406
            ....|..:||..|:|  ..:..|.|.||.||:.|:|.||..:||:       :||
Zfish   176 ECRSLEFLDLGYNRL--RVLTRTAFLGLSRLMELHLEHNQFSRIN-------FFL---------- 221

  Fly   407 GHIEDNAFLPLYNLHTLNLAENRLHTLDDKLFNGLYVLSKLTLNNNLISVVEPAVFKNCSDLKEL 471
                   |..|.||..|.|..||:..::..|....|.|.:|.::.|.|.|::|.||:...:|:.|
Zfish   222 -------FPRLANLRALYLQWNRIRAVNQGLPWSWYTLQRLDISGNEIQVLDPVVFQCLPNLQVL 279

  Fly   472 DLSSNQLNEVPR-ALQDLAMLRTLDLGENQ-------------IRTFDNQSFKNL-----HQLTG 517
            :|.||:|..|.: .:.....|.|:.|..|.             ::.|......|:     ..|.|
Zfish   280 NLESNKLANVSQEVVAAWISLTTISLAGNMWDCGPGICPLVVWLKNFRGTKDTNIICSSPKHLQG 344

  Fly   518 LRLIDNQIGNITVGMFQDLPRLSVLNLAKNRIQSIERGSFDKNFEL 563
            .::|:.....|....: ::...|.|.|.          :||.|::|
Zfish   345 EKVIEASKNYIDCDDY-EITAQSPLYLQ----------TFDPNYDL 379

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-7	NP_523797.1	LRR_8	135..201	CDD:290566	7/69 (10%)
		leucine-rich repeat	136..159	CDD:275380	6/26 (23%)
		leucine-rich repeat	160..190	CDD:275380	1/29 (3%)
		LRR_8	189..259	CDD:290566	12/69 (17%)
		leucine-rich repeat	191..214	CDD:275380	0/22 (0%)
		leucine-rich repeat	215..248	CDD:275380	8/32 (25%)
		LRR_RI	247..501	CDD:238064	79/267 (30%)
		LRR_8	247..308	CDD:290566	19/60 (32%)
		leucine-rich repeat	249..273	CDD:275380	5/23 (22%)
		leucine-rich repeat	274..297	CDD:275380	7/22 (32%)
		LRR_8	297..356	CDD:290566	21/58 (36%)
		leucine-rich repeat	298..321	CDD:275380	10/22 (45%)
		leucine-rich repeat	322..345	CDD:275380	7/22 (32%)
		LRR_8	345..406	CDD:290566	19/60 (32%)
		leucine-rich repeat	346..371	CDD:275380	9/24 (38%)
		leucine-rich repeat	372..395	CDD:275380	7/22 (32%)
		leucine-rich repeat	396..419	CDD:275380	3/22 (14%)
		LRR_8	419..478	CDD:290566	21/58 (36%)
		leucine-rich repeat	420..443	CDD:275380	6/22 (27%)
		leucine-rich repeat	444..467	CDD:275380	8/22 (36%)
		LRR_RI	466..622	CDD:238064	24/117 (21%)
		leucine-rich repeat	468..488	CDD:275380	7/20 (35%)
		LRR_8	491..549	CDD:290566	13/75 (17%)
		leucine-rich repeat	491..514	CDD:275380	6/40 (15%)
		leucine-rich repeat	515..536	CDD:275380	4/20 (20%)
		leucine-rich repeat	539..562	CDD:275380	6/22 (27%)
		leucine-rich repeat	563..585	CDD:275380	1/1 (100%)
		leucine-rich repeat	586..626	CDD:275380
		leucine-rich repeat	627..653	CDD:275380
		LRRCT	716..772	CDD:214507
		LRRNT	796..830	CDD:214470
		leucine-rich repeat	812..829	CDD:275380
		leucine-rich repeat	833..854	CDD:275380
		LRR_8	853..913	CDD:290566
		leucine-rich repeat	855..878	CDD:275380
		LRR_4	878..918	CDD:289563
		leucine-rich repeat	879..902	CDD:275380
		leucine-rich repeat	903..926	CDD:275380
		leucine-rich repeat	927..953	CDD:275380
		TIR	1098..1235	CDD:214587
lrrtm4l1	NP_001373591.1	leucine-rich repeat	60..83	CDD:275380	8/32 (25%)
		LRR_8	63..118	CDD:404697	18/65 (28%)
		leucine-rich repeat	84..107	CDD:275380	5/23 (22%)
		LRR_8	106..166	CDD:404697	23/59 (39%)
		leucine-rich repeat	108..131	CDD:275380	7/22 (32%)
		leucine-rich repeat	132..155	CDD:275380	10/22 (45%)
		PPP1R42	153..308	CDD:411060	54/180 (30%)
		leucine-rich repeat	156..179	CDD:275380	7/22 (32%)
		leucine-rich repeat	180..203	CDD:275380	9/24 (38%)
		leucine-rich repeat	204..227	CDD:275380	11/46 (24%)
		leucine-rich repeat	228..251	CDD:275380	6/22 (27%)
		leucine-rich repeat	252..275	CDD:275380	8/22 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100