DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8517 and TXNDC5

DIOPT Version :9

Sequence 1:	NP_611446.3	Gene:	CG8517 / 37268	FlyBaseID:	FBgn0034472	Length:	145	Species:	Drosophila melanogaster
Sequence 2:	NP_110437.2	Gene:	TXNDC5 / 81567	HGNCID:	21073	Length:	432	Species:	Homo sapiens

Alignment Length:	119	Identity:	36/119 - (30%)
Similarity:	58/119 - (48%)	Gaps:	5/119 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 KQPIFDVETRKDFEQRVINSDRPVVVDFHASWCCPCKALAPRLENVV--SEQEGRVRLARVDIDE 90
            ||.:::: :..:||..|...|.  .:.|.|.||..||||||..|.:.  .|....|::.:||..:
Human   188 KQGLYEL-SASNFELHVAQGDH--FIKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVDCTQ 249

  Fly    91 HGELALDYNVGSVPSLVVISNGKVVNRMVGLQTSEYLRKWLHKAVPHPPPEDTE 144
            |.||.....|...|:|:...:||.|::..|.:..|.||:::...:.......||
Human   250 HYELCSGNQVRGYPTLLWFRDGKKVDQYKGKRDLESLREYVESQLQRTETGATE 303

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8517	NP_611446.3	Thioredoxin_like	36..135	CDD:412351	32/100 (32%)
TXNDC5	NP_110437.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	40..63
		PDI_a_ERp46	61..164	CDD:239303
		ER_PDI_fam	66..432	CDD:273457	36/119 (30%)
		PDI_a_ERp46	190..290	CDD:239303	32/102 (31%)
		PDI_a_ERp46	323..424	CDD:239303
		Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	429..432
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910