DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment isopeptidase-T-3 and UBAC1

DIOPT Version :9

Sequence 1:	NP_001261098.1	Gene:	isopeptidase-T-3 / 37261	FlyBaseID:	FBgn0028372	Length:	561	Species:	Drosophila melanogaster
Sequence 2:	NP_057256.2	Gene:	UBAC1 / 10422	HGNCID:	30221	Length:	405	Species:	Homo sapiens

Alignment Length:	368	Identity:	100/368 - (27%)
Similarity:	172/368 - (46%)	Gaps:	49/368 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   197 DDPDSIQLFAPDVRHLNPRYRLYRAEYFGGE--LNEGDTLAQLKVRNNETFILSPRR--NTLPQT 257
            :||.||           ..::|..|   ..|  |::..|:.:..:::.:..:|..:|  :.||:.
Human    53 EDPKSI-----------THHKLIHA---ASERVLSDARTILEENIQDQDVLLLIKKRAPSPLPKM 103

  Fly   258 V------SRIREVPGPNEQLVESATRYVPVNCNQLPTIDINEIFQQSNI---QYDVRKVLISLAQ 313
            .      .:.::...|:::.:..||.       .||:.:::....|:|:   |.::||:|:||.:
Human   104 ADVSAEEKKKQDQKAPDKEAILRATA-------NLPSYNMDRAAVQTNMRDFQTELRKILVSLIE 161

  Fly   314 ASAAVIGAGPYAPRLIAMLKQRLINRRNQQAD--TLQCLVDMGFKRELAAFALKAHNGIYSTTME 376
            .:..::...|.|..|.......|....:::.|  .|:.|.:|||....|..||:.::......||
Human   162 VAQKLLALNPDAVELFKKANAMLDEDEDERVDEAALRQLTEMGFPENRATKALQLNHMSVPQAME 226

  Fly   377 WLIQNQNE---------ENPQEPPGMNMQHSLSSISPSTIVTNNETIENTAALIEIVRIYSHRDS 432
            |||::..:         :.|.|..|.....|.::...|  .|:.|..:....:.:.:|  ..|:.
Human   227 WLIEHAEDPTIDTPLPGQAPPEAEGATAAASEAAAGAS--ATDEEARDELTEIFKKIR--RKREF 287

  Fly   433 PPSDEIVESLTEMGFEETAVLAALKKTGNNKASACEWLCDNRSGSVIELREGLAPDSPILKVILE 497
            ......|.||.||||:|..|:.||:...|.:.:|||||..:|..|..||.:|:.||||:.:.||:
Human   288 RADARAVISLMEMGFDEKEVIDALRVNNNQQNAACEWLLGDRKPSPEELDKGIDPDSPLFQAILD 352

  Fly   498 MPQVQMTLSNPKTFLAFLGILENEHAIRVWRGDNDTTSVITHI 540
            .|.||:.|:||||.|||..:|||......|..|.:|..|:..|
Human   353 NPVVQLGLTNPKTLLAFEDMLENPLNSTQWMNDPETGPVMLQI 395

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
isopeptidase-T-3	NP_001261098.1	UBA_like_SF	345..384	CDD:304366	14/40 (35%)
isopeptidase-T-3	NP_001261098.1	UBA2_KPC2	434..472	CDD:270489	17/37 (46%)
UBAC1	NP_057256.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	101..120		1/18 (6%)
		UBA1_KPC2	195..232	CDD:270488	13/36 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	235..271		7/37 (19%)
		UBA2_KPC2	290..327	CDD:270489	17/36 (47%)
		STI1	353..392	CDD:128966	17/38 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	57	1.000	Domainoid score	I10937
eggNOG	1	0.900	-	-		E1_28IDF
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H9409
Inparanoid	1	1.050	128	1.000	Inparanoid score	I4684
Isobase	1	0.950	-	0	Normalized mean entropy	S7838
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1163759at2759
OrthoFinder	1	1.000	-	-		FOG0006086
OrthoInspector	1	1.000	-	-		oto91133
orthoMCL	1	0.900	-	-		OOG6_108746
Panther	1	1.100	-	-	LDO	PTHR46738
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4908
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.810