DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sm and Hnrnpll

DIOPT Version :9

Sequence 1:	NP_001246428.1	Gene:	sm / 37254	FlyBaseID:	FBgn0003435	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	NP_659051.3	Gene:	Hnrnpll / 72692	MGIID:	1919942	Length:	591	Species:	Mus musculus

Alignment Length:	593	Identity:	198/593 - (33%)
Similarity:	275/593 - (46%)	Gaps:	160/593 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 NGASNGSGASGAGGGGATIVVTEGPQNKKIRTGVQQPGENDVH-------MHARS---------- 51
            :|...|||....|.||       ||::..:.|    .|....|       :|.|.
Mouse    88 DGDEGGSGGDEGGSGG-------GPRSMPLST----EGGGSHHKVSVSPVVHVRGLCESVVEADL 141

  Fly    52 ---------------TPQQNQ---------------------------QQALMNKSNDDLRRKRP 74
                           .|.:.|                           |||..|.|... |..||
Mouse   142 VEALEKFGTICYVMMMPFKRQALVEFENIDSAKECVTFAADVPVYIAGQQAFFNYSTSK-RITRP 205

  Fly    75 ETTRP----NHILLFTIINPFYPITVDVLHKICHPHGQVLRIVIFKKNGVQAMVEFDNLDAATRA 135
            ..|..    |.:||.:|.||.||||||||:.:|:|.|:|.||||||:||:||||||:::..|.:|
Mouse   206 GNTDDPSGGNKVLLLSIQNPLYPITVDVLYTVCNPVGKVQRIVIFKRNGIQAMVEFESVLCAQKA 270

  Fly   136 RENLNGADIYAGCCTLKIDYAKPEKLNVYKNEPDTSWDYTLSTVKEIGNGRSPLLQEPLYVATLS 200
            :..|||||||||||||||:||:|.:|||.:|:.| |||||           .|.|.
Mouse   271 KAALNGADIYAGCCTLKIEYARPTRLNVIRNDND-SWDYT-----------KPYLG--------- 314

  Fly   201 TPQQHVSHQHHHHLRQQQQQQHQQQAPQQQPHPQHLHHQQQLVAPAQSHNLYQFKEPPLLGPGAA 265
                          |:.:.:..|:||.... ||....|.                     |.|:.
Mouse   315 --------------RRDRGKGRQRQAILGD-HPSSFRHD---------------------GYGSH 343

  Fly   266 FPPFGAPEYH----TTTPENWKGAAIHPTGLMKEPAGVVPGRNAPVAFTPQGQAQGAVMMVYGLD 326
            .|....|..:    ..|||           |:..|   :|  .|..::...|...|:|:||.||.
Mouse   344 GPLLPLPSRYRMGSRDTPE-----------LVAYP---LP--QASSSYMHGGSPSGSVVMVSGLH 392

  Fly   327 HDTSNTDKLFNLVCLYGNVARIKFLKTKEGTAMVQMGDAVAVERCVQHLNNIPVGTGGKIQIAFS 391
            ....|..::|||.|||||:.::||:||..|||:|:|||..||||.|.||||:.: .|.::.:..|
Mouse   393 QLKMNCSRVFNLFCLYGNIEKVKFMKTIPGTALVEMGDEYAVERAVTHLNNVKL-FGKRLNVCVS 456

  Fly   392 KQNFL--SEVINPFLLPDHSPSFKEYTGSKNNRFLSPAQASKNRIQPPSKILHFFNTPPGLTEDQ 454
            ||:.:  |::   |.|.|.:.|:|::..||||||.|..|||||.|||||.:||::|.|..:||:.
Mouse   457 KQHSVVPSQI---FELEDGTSSYKDFAMSKNNRFTSAGQASKNIIQPPSCVLHYYNVPLCVTEET 518

  Fly   455 LIGIFNIKDV-PATSVRLFPLK-TERSSSGLIEFSNISQAVLAIMKCNHLPIEGKGTKFPFIMKL 517
            ...:.|..:| |....::|..| :.::.|||:|:...:.||.|:...||..|.......|:.:||
Mouse   519 FTKLCNDHEVLPFIKYKVFDAKASAKTLSGLLEWKCKTDAVEALTALNHYQIRVPNGSNPYTLKL 583

  Fly   518 CFSSSKSM 525
            |||:|..:
Mouse   584 CFSTSSHL 591

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sm	NP_001246428.1	RRM2_hnRNPL_like	80..165	CDD:241138	55/84 (65%)
		RRM3_hnRNPL_like	319..390	CDD:240870	35/70 (50%)
		RRM4_hnRNPL_like	437..519	CDD:240873	26/83 (31%)
Hnrnpll	NP_659051.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..120		11/42 (26%)
		RRM1_hnRPLL	122..205	CDD:241225	10/83 (12%)
		hnRNP-L_PTB	123..590	CDD:273733	186/544 (34%)
		RRM2_hnRPLL	214..309	CDD:241230	60/95 (63%)
		RRM3_hnRPLL	385..455	CDD:241144	35/70 (50%)
		RRM4_hnRPLL	501..585	CDD:241149	26/83 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839750
Domainoid	1	1.000	117	1.000	Domainoid score	I5889
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	297	1.000	Inparanoid score	I2705
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48602
OrthoDB	1	1.010	-	-		D1545178at2759
OrthoFinder	1	1.000	-	-		FOG0002729
OrthoInspector	1	1.000	-	-		otm44061
orthoMCL	1	0.900	-	-		OOG6_104479
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1821
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.810