DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sm and heph

DIOPT Version :9

Sequence 1:NP_001246428.1 Gene:sm / 37254 FlyBaseID:FBgn0003435 Length:552 Species:Drosophila melanogaster
Sequence 2:NP_001247399.1 Gene:heph / 48571 FlyBaseID:FBgn0011224 Length:898 Species:Drosophila melanogaster


Alignment Length:526 Identity:126/526 - (23%)
Similarity:205/526 - (38%) Gaps:130/526 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 EGPQNKKIRT--GVQQPGE----------NDVHMHARSTPQQNQQQA-LMNKSNDDLRRKRPETT 77
            :|..|....:  .||.|..          |....:|.|:...|.... |.|.|..:.........
  Fly   449 QGHNNSTAHSDYSVQSPASGSPLPLSAAANATSNNANSSSDSNSAMGILQNTSAVNAGGNTNAAG 513

  Fly    78 RPNHILLFTIINPFYPITVDVLHKICHPHGQVLRIVIF-KKNGVQAMVEFDNLDAATRARENLNG 141
            .||.:|...:.:..||:::|:||:|...:|:||:||.| |.|..||::::.:.::|..|:..|:|
  Fly   514 GPNTVLRVIVESLMYPVSLDILHQIFQRYGKVLKIVTFTKNNSFQALIQYPDANSAQHAKSLLDG 578

  Fly   142 ADIYAGCCTLKIDYAKPEKLNV-YKNEPDTSWDYT-------------LSTVKEIGNGRSPLLQE 192
            .:||.|||||:||.:|...||| |.|  |.|.|:|             :.|...:.|....||  
  Fly   579 QNIYNGCCTLRIDNSKLTALNVKYNN--DKSRDFTNPALPPGEPGVDIMPTAGGLMNTNDLLL-- 639

  Fly   193 PLYVATLSTPQQHVSHQHHHHLRQQQQQQHQQQAPQQQPHPQHLHHQQQLVAPAQSHNLYQFKEP 257
               :|....|...|:.                                                 
  Fly   640 ---IAARQRPSLSVNG------------------------------------------------- 652

  Fly   258 PLLGPGAAFPPF----GAP---EYHTTTPENWKGAAIHPTGLMKEPAGVVPGRNAPVAFTPQGQA 315
              ||.....|||    |.|   .|:...| |....::..:|.::..|             |..:.
  Fly   653 --LGAPGVLPPFALGLGTPLTGGYNNALP-NLAAFSLANSGALQTTA-------------PAMRG 701

  Fly   316 QGAVMMVYGLDHDTSNTDKLFNLVCLYGNVARIKFLKTKEGTAMVQMGDAVAVERCVQHLNNIPV 380
            ...|::|..|:.:....|.||.|..:||:|.|:|.|..|:.:|::||.:.......:.||:.:.:
  Fly   702 YSNVLLVSNLNEEMVTPDALFTLFGVYGDVQRVKILYNKKDSALIQMAEPQQAYLAMSHLDKLRL 766

  Fly   381 GTGGKIQIAFSKQNFLSEVINPFLLP-DHSPS---FKEYTGSKNNRFLSPAQASKNRIQPPSKIL 441
             .|..|::..||...:.       || :..|.   .::|:.:..:||..|...:...|.|||..|
  Fly   767 -WGKPIRVMASKHQAVQ-------LPKEGQPDAGLTRDYSQNPLHRFKKPGSKNYQNIYPPSATL 823

  Fly   442 HFFNTPPGLTEDQLIGIFNIKDVPATSVRLFPLKTERSSSGLIEFSNISQAVLAIMK-------- 498
            |..|.|...:||.:...|........:.:.||   :.....|::..::.:||||::|        
  Fly   824 HLSNIPSSCSEDDIKEAFTSNSFEVKAFKFFP---KDRKMALLQLLSVEEAVLALIKMHNHQLSE 885

  Fly   499 CNHLPI 504
            .|||.:
  Fly   886 SNHLRV 891

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
smNP_001246428.1 RRM2_hnRNPL_like 80..165 CDD:241138 35/86 (41%)
RRM3_hnRNPL_like 319..390 CDD:240870 21/70 (30%)
RRM4_hnRNPL_like 437..519 CDD:240873 20/76 (26%)
hephNP_001247399.1 hnRNP-L_PTB 366..898 CDD:273733 126/526 (24%)
RRM1_PTBP1_like 368..448 CDD:241132
RRM2_PTBP1_like 516..611 CDD:241137 40/96 (42%)
RRM3_PTBP1_like 705..778 CDD:240869 22/73 (30%)
RRM4_PTBP1_like 822..897 CDD:240871 18/73 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45452972
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D107699at50557
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
32.850

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