DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sm and hnrnpl

DIOPT Version :9

Sequence 1:	NP_001246428.1	Gene:	sm / 37254	FlyBaseID:	FBgn0003435	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	NP_957393.1	Gene:	hnrnpl / 394074	ZFINID:	ZDB-GENE-040426-710	Length:	536	Species:	Danio rerio

Alignment Length:	541	Identity:	202/541 - (37%)
Similarity:	279/541 - (51%)	Gaps:	109/541 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 NGASNGSGASGAGGGGATIVVTEGPQNKKIRTGVQQPGENDVHMHAR-STPQQNQQQALMNKSND 67
            |||||                           .|.....|.:::..| |....:..|.:...::.
Zfish    87 NGASN---------------------------AVTYANNNQIYIAGRPSYINYSTSQKISRPTDS 124

  Fly    68 DLRRKRPETTRPNHILLFTIINPFYPITVDVLHKICHPHGQVLRIVIFKKNGVQAMVEFDNLDAA 132
            |      :|...|::||.||:||.||||.|||:.||:..|.|.|||||:|||||||||||::.:|
Zfish   125 D------DTRSVNNVLLLTIMNPIYPITSDVLYTICNNCGPVQRIVIFRKNGVQAMVEFDSVQSA 183

  Fly   133 TRARENLNGADIYAGCCTLKIDYAKPEKLNVYKNEPDTSWDYT---LSTVKEIGNGRSPLLQEPL 194
            .||:.:|||||||:|||||||:||||.:|||:||:.|| ||||   ||......:|.....|:|
Zfish   184 QRAKASLNGADIYSGCCTLKIEYAKPTRLNVFKNDQDT-WDYTNPNLSGQDADADGNWNNSQDP- 246

  Fly   195 YVATLSTPQQHVSHQHHHHLRQQQQQQHQQQAPQQQPHPQHLH-HQQQLVAPAQSHNLYQFKE-- 256
                .:.|.           ::|:|.......|.:...||..: |......|......|:.:.
Zfish   247 ----NANPN-----------KRQRQPALLGDHPPEYGSPQGGYGHYDDTYGPPPPPPHYEGRRMG 296

  Fly   257 PPLLGPGAAFPPFGAPEY-HTTTPENWKGAAIHPTGLMKEPAGVVPGRNAPVAFTPQGQAQGAVM 320
            || :|.|...|.:|..:| |...|                     |..||        .|...|:
Zfish   297 PP-IGRGRGVPRYGGAQYGHGPPP---------------------PDYNA--------HADSPVV 331

  Fly   321 MVYGLDHDTSNTDKLFNLVCLYGNVARIKFLKTKEGTAMVQMGDAVAVERCVQHLNNIPVGTGGK 385
            ||||||....|.|::||:.||||||.|:||:|:|.|.|||:|||..||:|.|.||||..: .|.|
Zfish   332 MVYGLDPVKINADRVFNIFCLYGNVERVKFMKSKPGAAMVEMGDCYAVDRAVSHLNNTML-FGQK 395

  Fly   386 IQIAFSKQNFLSEVINP---FLLPDHSPSFKEYTGSKNNRFLSPAQASKNRIQPPSKILHFFNTP 447
            :.:..|||    :.|.|   :.|.|.|.|||::.|.:||||.:..||:|||||.||.:|||||:.
Zfish   396 LNVCVSKQ----QAIMPGQSYQLEDGSCSFKDFHGYRNNRFTTSEQAAKNRIQQPSNVLHFFNSQ 456

  Fly   448 PGLTEDQLIGIFN-------IKDVPATSVRLFPLKTERSSSGLIEFSNISQAVLAIMKCNHLPIE 505
            |    |..:..|:       ||.  ..||:||..|.:||||||:|:.:::.|:.|:...||..::
Zfish   457 P----DSSVEAFSEICEELGIKS--PVSVKLFTGKVDRSSSGLLEWESVNDAMEALALMNHYQMK 515

  Fly   506 GKGTKFPFIMKLCFSSSKSMN 526
            .....:|:.:|||||:::..|
Zfish   516 NPSGPYPYTLKLCFSTAQHAN 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sm	NP_001246428.1	RRM2_hnRNPL_like	80..165	CDD:241138	58/84 (69%)
		RRM3_hnRNPL_like	319..390	CDD:240870	39/70 (56%)
		RRM4_hnRNPL_like	437..519	CDD:240873	31/88 (35%)
hnrnpl	NP_957393.1	hnRNP-L_PTB	39..534	CDD:273733	201/537 (37%)
		RRM1_hnRNPL	39..118	CDD:241224	10/57 (18%)
		RRM2_hnRNPL	128..227	CDD:241229	66/99 (67%)
		Bindin	265..>322	CDD:251078	15/78 (19%)
		RRM_SF	330..403	CDD:302621	40/73 (55%)
		RRM4_hnRNPL	446..529	CDD:241148	31/88 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583833
Domainoid	1	1.000	114	1.000	Domainoid score	I6030
eggNOG	1	0.900	-	-		E1_KOG1456
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1174
Inparanoid	1	1.050	290	1.000	Inparanoid score	I2784
OMA	1	1.010	-	-		QHG48602
OrthoDB	1	1.010	-	-		D1545178at2759
OrthoFinder	1	1.000	-	-		FOG0002729
OrthoInspector	1	1.000	-	-		otm24596
orthoMCL	1	0.900	-	-		OOG6_104479
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R10802
SonicParanoid	1	1.000	-	-		X1821
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.700