DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sm and ptbp1b

DIOPT Version :9

Sequence 1:	NP_001246428.1	Gene:	sm / 37254	FlyBaseID:	FBgn0003435	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	NP_001116126.1	Gene:	ptbp1b / 321220	ZFINID:	ZDB-GENE-030131-9796	Length:	564	Species:	Danio rerio

Alignment Length:	483	Identity:	130/483 - (26%)
Similarity:	198/483 - (40%)	Gaps:	103/483 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 NDVHMHARSTPQQNQQQALMNKSND------DLRRKRPE-TTRPNHILLFTIINPFYPITVDVLH 100
            |...:...::|.|.:.||.:...|.      .|....|. .|.|:.:|...:.|.|||:|:||||
Zfish   144 NHKELKTDNSPNQVRAQAALQAVNAVQTGSLTLGGVDPSGMTGPSPVLRVIVENLFYPVTLDVLH 208

  Fly   101 KICHPHGQVLRIVIFKKNG-VQAMVEFDNLDAATRARENLNGADIYAGCCTLKIDYAKPEKLNV- 163
            :|....|.||:::.|.||. .||:::|.:...|..|:..|:|.:||.|||||:|.::|...|||
Zfish   209 QIFSKFGTVLKVITFTKNNQFQALLQFTDGLTAQHAKLALDGQNIYNGCCTLRISFSKLTSLNVK 273

  Fly   164 YKNEPDTSWDYTLSTVKEIGNGRSPLLQEPLYVATLSTPQQHVSHQHHHHLRQQQQQQHQQQAPQ 228
            |.|  |.|.|||                                               :...|.
Zfish   274 YNN--DKSRDYT-----------------------------------------------RPDLPT 289

  Fly   229 QQPHPQHLHHQQQLVAPAQSHNLYQFKEPPLL--GPGA---AFPPFGAPEYHTTTPENWKGAAIH 288
            ....|...||   .||.|       |..|.::  .|.|   ||||..|.:....|.....||...
Zfish   290 GDSQPALEHH---AVAAA-------FAAPGIISAAPYASAHAFPPAFAIQQAGLTIPGVPGALAS 344

  Fly   289 PTGLMKEPAGVVPGRNAPVAFT-----PQGQAQGAVMMVYGLDHDTSNTDKLFNLVCLYGNVARI 348
            .|         :||..|..|..     |.......||:|..|:.:......||.|..:||:|.|:
Zfish   345 LT---------IPGAAAAAAAASRLGFPTLTGTHCVMLVSNLNPERVTPHCLFILFGVYGDVLRV 400

  Fly   349 KFLKTKEGTAMVQMGDAVAVERCVQHLNNIPVGTGGKIQIAFSKQNFLSEVINPFLLP----DHS 409
            |.:..|:..|::||.|....:..:.|||...: .|..::|..||...:.       :|    :..
Zfish   401 KIMFNKKENALIQMSDGTQAQLAMSHLNGQKL-YGRPLRITLSKHTTVQ-------MPREGHEDQ 457

  Fly   410 PSFKEYTGSKNNRFLSPAQASKNRIQPPSKILHFFNTPPGLTEDQLIGIFNIKDVPATSVRLFPL 474
            ...|:|:.|..:||..|...:.:.|.|||..||..|.||.:.||.|..:|........:.:.|
Zfish   458 GLTKDYSNSPLHRFKKPGSKNYSNIFPPSSTLHLSNIPPSVVEDDLKLLFGSSGALVKNFKFF-- 520

  Fly   475 KTERSSSGLIEFSNISQAVLAIMKC-NH 501
            :.:|..: ||:.|::.:|:.::::. ||
Zfish   521 QKDRKMA-LIQMSSVEEAIESLIQFHNH 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sm	NP_001246428.1	RRM2_hnRNPL_like	80..165	CDD:241138	36/86 (42%)
		RRM3_hnRNPL_like	319..390	CDD:240870	22/70 (31%)
		RRM4_hnRNPL_like	437..519	CDD:240873	19/66 (29%)
ptbp1b	NP_001116126.1	hnRNP-L_PTB	69..564	CDD:273733	130/483 (27%)
		RRM_SF	71..151	CDD:302621	1/6 (17%)
		RRM2_PTBP1_like	188..283	CDD:241137	41/96 (43%)
		RRM_SF	371..463	CDD:302621	26/99 (26%)
		RRM_SF	484..564	CDD:302621	20/67 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1545178at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920