Protein Alignment sm and HNRNPL

DIOPT Version :9

• Sequence 1: NP_001246428.1
• Gene: sm / 37254
• FlyBaseID: FBgn0003435
• Length: 552
• Species: Drosophila melanogaster
• Sequence 2: NP_001372580.1
• Gene: HNRNPL / 3191
• HGNCID: 5045
• Length: 626
• Species: Homo sapiens
• Alignment Length: 609
• Identity: 208/609 - (34%)
• Similarity: 294/609 - (48%)
• Gaps: 150/609 - (24%)

  Fly     5 GASNGSGASGAGGGG-----------ATIVVTEG--------------------------PQNKK 32
            |...|:||:|.||||           :.:|...|                          |:.::
Human    75 GGGGGAGAAGGGGGGENYDDPHKTPASPVVHIRGLIDGVVEADLVEALQEFGPISYVVVMPKKRQ 139

  Fly    33 IR----------TGVQQPGENDVHM--HARSTPQQNQQQALMNKSNDDLRRKRPETTRPNHILLF 85
            ..          ..|....:|.:::  |.........|:......:||.|       ..|.:|||
Human   140 ALVEFEDVLGACNAVNYAADNQIYIAGHPAFVNYSTSQKISRPGDSDDSR-------SVNSVLLF 197

  Fly    86 TIINPFYPITVDVLHKICHPHGQVLRIVIFKKNGVQAMVEFDNLDAATRARENLNGADIYAGCCT 150
            ||:||.|.||.|||:.||:|.|.|.|||||:|||||||||||::.:|.||:.:|||||||:||||
Human   198 TILNPIYSITTDVLYTICNPCGPVQRIVIFRKNGVQAMVEFDSVQSAQRAKASLNGADIYSGCCT 262

  Fly   151 LKIDYAKPEKLNVYKNEPDTSWDYTLSTVKEIGN-GRSPLLQEPLYVATLSTPQQHVSHQHHHHL 214
            |||:||||.:|||:||:.|| ||||...:...|: |.:|
Human   263 LKIEYAKPTRLNVFKNDQDT-WDYTNPNLSGQGDPGSNP-------------------------- 300

  Fly   215 RQQQQQQHQQQAPQQQPHPQHLHH--------QQQLVAPAQSHNLYQFKEPPLLGPGAAFPPFGA 271
                 .:.|:|.|....||.....        .:...|||:..   ..|..|:|....:.|| |.
Human   301 -----NKRQRQPPLLGDHPAEYGEGRGFPSVDSRGSCAPARRP---PCKFSPVLPLFPSHPP-GG 356

  Fly   272 PE--YHT--------TTPENWKGAAIHPTGLMKEPAGVVPGRNAPVAFTPQ-------------- 312
            |.  ||:        ..|.:::|..:.|      |.|  ..|..|..:.||
Human   357 PHGGYHSHYHDEGYGPPPPHYEGRRMGP------PVG--GHRRGPSRYGPQYGHPPPPPPPPEYG 413

  Fly   313 GQAQGAVMMVYGLDHDTSNTDKLFNLVCLYGNVARIKFLKTKEGTAMVQMGDAVAVERCVQHLNN 377
            ..|...|:||||||....|.|::||:.||||||.::||:|:|.|.|||:|.|..||:|.:.||||
Human   414 PHADSPVLMVYGLDQSKMNCDRVFNVFCLYGNVEKVKFMKSKPGAAMVEMADGYAVDRAITHLNN 478

  Fly   378 IPVGTGGKIQIAFSKQNFLSEVINPFLLP-------DHSPSFKEYTGSKNNRFLSPAQASKNRIQ 435
             ....|.|:.:..|||        |.::|       |.|.|:|:::.|:||||.:|.||:|||||
Human   479 -NFMFGQKLNVCVSKQ--------PAIMPGQSYGLEDGSCSYKDFSESRNNRFSTPEQAAKNRIQ 534

  Fly   436 PPSKILHFFNTPPGLTEDQLIGIFNIKDVP-ATSVRLFPLKTERSSSGLIEFSNISQAVLAIMKC 499
            .||.:|||||.|..:||:....|.:...|. .:||::|..|:|||||||:|:.:.|.|:..:...
Human   535 HPSNVLHFFNAPLEVTEENFFEICDELGVKRPSSVKVFSGKSERSSSGLLEWESKSDALETLGFL 599

  Fly   500 NHLPIEGKGTKFPFIMKLCFSSSK 523
            ||..::.....:|:.:|||||:::
Human   600 NHYQMKNPNGPYPYTLKLCFSTAQ 623

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sm	NP_001246428.1	RRM2_hnRNPL_like	80..165	CDD:241138	59/84 (70%)
		RRM3_hnRNPL_like	319..390	CDD:240870	36/70 (51%)
		RRM4_hnRNPL_like	437..519	CDD:240873	31/82 (38%)
HNRNPL	NP_001372580.1	hnRNP-L_PTB	100..624	CDD:273733	199/584 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	117	1.000	Domainoid score	I5922
eggNOG	1	0.900	-	-		E1_KOG1456
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1174
Inparanoid	1	1.050	297	1.000	Inparanoid score	I2734
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48602
OrthoDB	1	1.010	-	-		D1545178at2759
OrthoFinder	1	1.000	-	-		FOG0002729
OrthoInspector	1	1.000	-	-		otm42008
orthoMCL	1	0.900	-	-		OOG6_104479
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R10802
SonicParanoid	1	1.000	-	-		X1821
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.770