Protein Alignment TTLL6A and TTLL7

DIOPT Version :10

• Sequence 1: NP_611433.3
• Gene: TTLL6A / 37253
• FlyBaseID: FBgn0034459
• Length: 867
• Species: Drosophila melanogaster
• Sequence 2: NP_078962.4
• Gene: TTLL7 / 79739
• HGNCID: 26242
• Length: 887
• Species: Homo sapiens
• Alignment Length: 782
• Identity: 231/782 - (29%)
• Similarity: 373/782 - (47%)
• Gaps: 103/782 - (13%)

  Fly   135 VEHTRFQLVAKVTRNMGFQHVP-EHRLWNIQWSDSTPHHDLLRNMKRFQQINHFPGMVEICRKDL 198
            |..|:|::|..|...|||...| |....|:.|.||....:.:..::.:|:|||||||.||||||.
Human    45 VAGTKFEIVRLVIDEMGFMKTPDEDETSNLIWCDSAVQQEKISELQNYQRINHFPGMGEICRKDF 109

  Fly   199 LSRNLNRMLKMFPGDYRIFPKTWLMPTDAYDVAIYANKHK-----RTFILKPYSAGQGRGIWITT 258
            |:||:.:|:|..|.||...|:||:.|.:......|..:.|     :|||:||.:...|.||.:..
Human   110 LARNMTKMIKSRPLDYTFVPRTWIFPAEYTQFQNYVKELKKKRKQKTFIVKPANGAMGHGISLIR 174

  Fly   259 DLRTVGKREKLICQTYIERPLLIDGYKFDLRVYTLVTSVDPLRIFVYNEGLARFATQKYVPPTTG 323
            :...:..::.||.|.|||:|.|::|||||||:|.||||.|||:||:|::||.|..|:||:||...
Human   175 NGDKLPSQDHLIVQEYIEKPFLMEGYKFDLRIYILVTSCDPLKIFLYHDGLVRMGTEKYIPPNES 239

  Fly   324 NSHNVFMHLTNYCLNRRNSQYMVGNGPEAGSKRKLSAFNKWLVDHNYDVGEFWASVDDAIIKTLI 388
            |...::||||||.:|:.|..:........||||.:..|.::|..:.:||.:||:.:.:.::||||
Human   240 NLTQLYMHLTNYSVNKHNEHFERDETENKGSKRSIKWFTEFLQANQHDVAKFWSDISELVVKTLI 304

  Fly   389 SAWPTLKHNYNVCFPKHDKIQAS--FQLLGFDILVDWKLKPYILEVNHTPSLSADESVDMEVKRP 451
            .|.|.:.|.|.:|.|.......|  |::||||||:|.||||::||:|..||...|:.:|.:|||.
Human   305 VAEPHVLHAYRMCRPGQPPGSESVCFEVLGFDILLDRKLKPWLLEINRAPSFGTDQKIDYDVKRG 369

  Fly   452 LIRDTLNMLSTALVDKEQIIRDDRTEHRARLLRNIYNKKAAAQ-MPGYSSPIREVGGHDVRQACS 515
            ::.:.|.:|:....||    |.:..:.:|...|.:|.:.:..: :||.|.  .|...|.:.:...
Human   370 VLLNALKLLNIRTSDK----RRNLAKQKAEAQRRLYGQNSIKRLLPGSSD--WEQQRHQLERRKE 428

  Fly   516 -----IGALTQQIAWEE---SHLGNYRRIMPPRDSSKVNYYCKFYEQNKQPMFADTVASRRREQL 572
                 :..:.:||:.||   .|:||||||.||.|.:.:..|........|...:...||.:||..
Human   429 ELKERLAQVRKQISREEHENRHMGNYRRIYPPEDKALLEKYENLLAVAFQTFLSGRAASFQRELN 493

  Fly   573 NLQAIQKHQRERQQDLIQQQQIHTQAQNRMGK--HVRWPGDLVQGEQVNPVILQ----------- 624
            |  .:::.:.|...||::|.:|  ..:..|||  ..|.|..|....:...::.:
Human   494 N--PLKRMKEEDILDLLEQCEI--DDEKLMGKTTKTRGPKPLCSMPESTEIMKRPKYCSSDSSYD 554

  Fly   625 -----SRRRREEAEAYAKKHRALIAREIQRQKEQLLAPTCAKERLGIWQSVRRE---KRSQFSPK 681
                 |.....|.|.|..|.|       ::|....|.|:...:.:....|:||.   .||..:..
Human   555 SSSSSSESDENEKEEYQNKKR-------EKQVTYNLKPSNHYKLIQQPSSIRRSVSCPRSISAQS 612

  Fly   682 RGSSITKAYRRKQ----------QRNLSLRARQQRMIEMEAQRDAKFLEQHAQKQRLEGGRKTGQ 736
            ..|..|:.:..:|          .|:.||......|..:....||  ...::|........||.:
Human   613 PSSGDTRPFSAQQMISVSRPTSASRSHSLNRASSYMRHLPHSNDA--CSTNSQVSESLRQLKTKE 675

  Fly   737 SESPNLLSKITAKSKTSLK-KKMKPKGKPELKKETLQEG--NHCQMTKSKVELTPGSKARAFANW 798
            .|     ..:|:::...|| .|::..||.:.:.|.|.|.  ::.:..|:||           |::
Human   676 QE-----DDLTSQTLFVLKDMKIRFPGKSDAESELLIEDIIDNWKYHKTKV-----------ASY 724

  Fly   799 TARTINEAETDQLLS-------------WRKERANQLNETRLRELIFSK-MYENGHLTKNDIKCF 849
            ....::..:..::|.             |:.....::|..|:...:|:: ::..|....|   ||
Human   725 WLIKLDSVKQRKVLDIVKTSIRTVLPRIWKVPDVEEVNLYRIFNRVFNRLLWSRGQGLWN---CF 786

  Fly   850 PD 851
            .|
Human   787 CD 788

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TTLL6A	NP_611433.3	TTL	181..471	CDD:397308	126/296 (43%)
TTLL7	NP_078962.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21
		TTL	91..376	CDD:397308	122/284 (43%)
		YhaN	<384..>474	CDD:443752	26/95 (27%)
		c-MTBD region. /evidence=ECO:0000269|PubMed:25959773	388..450		12/63 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	519..621		22/108 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	651..676		5/26 (19%)