Protein Alignment TTLL6A and TTLL3

DIOPT Version :10

• Sequence 1: NP_611433.3
• Gene: TTLL6A / 37253
• FlyBaseID: FBgn0034459
• Length: 867
• Species: Drosophila melanogaster
• Sequence 2: NP_001021100.3
• Gene: TTLL3 / 26140
• HGNCID: 24483
• Length: 915
• Species: Homo sapiens
• Alignment Length: 693
• Identity: 151/693 - (21%)
• Similarity: 248/693 - (35%)
• Gaps: 230/693 - (33%)

  Fly   178 MKRFQQI-------NHFPGMVEICRKDLLSRNLNRMLKM--FPGDYRIFPKTWLMPTDAYDVAIY 233
            ::|:.|:       .|....|:.| :|:| :.|..::..  ..||..|    |
Human   377 LQRYYQVVHEGAELRHLDTQVQRC-EDIL-QQLQAVVPQIDMEGDRNI----W------------ 423

  Fly   234 ANKHKRTFILKPYSAGQGRGIWITTDLR----------TVGKREKLICQTYIERPLLIDGYKFDL 288
                    |:||.:..:||||.....|.          .|.|..|.:.|.||||||||.|.||||
Human   424 --------IVKPGAKSRGRGIMCMDHLEEMLKLVNGNPVVMKDGKWVVQKYIERPLLIFGTKFDL 480

  Fly   289 RVYTLVTSVDPLRIFVYNEGLARFATQKYVPPTTGNS-----HNVFMHLTNYCL--------NRR 340
            |.:.|||..:||.::.|.:...||:||.:......||     :::..||.|.|.        |..
Human   481 RQWFLVTDWNPLTVWFYRDSYIRFSTQPFSLKNLDNSVHLCNNSIQKHLENSCHRHPLLPPDNMW 545

  Fly   341 NSQYMVGNGPEAGSKRKLSAFNKWLVDHNYDVGEFWASV-----DDAIIKTLISAWPTLKHNYNV 400
            :||....:..|.|:...                  |:::     .||:|..|.::..|::..
Human   546 SSQRFQAHLQEMGAPNA------------------WSTIIVPGMKDAVIHALQTSQDTVQCR--- 589

  Fly   401 CFPKHDKIQASFQLLGFDILVDWKLKPYILEVNHTPSLSADESVDMEVKRPLIRDTLNMLSTALV 465
                    :|||:|.|.|.:.....:|:::|:|.:|:::...:|...:...:..|||.::...::
Human   590 --------KASFELYGADFVFGEDFQPWLIEINASPTMAPSTAVTARLCAGVQADTLRVVIDRML 646

  Fly   466 DKEQIIRDDRTEHRARLLRN--------IYNKKAAAQMPGYSSPIREVGGHDVRQ---AC----- 514
            |                 ||        || |:.|.::|.|......|.|..:::   .|
Human   647 D-----------------RNCDTGAFELIY-KQPAVEVPQYVGIRLLVEGFTIKKPMAMCHRRMG 693

  Fly   515 ---SIGALTQQIAWEESHLGNYRRIMPPRDSSKVNYYCKFYEQNKQPMFADTVASRRREQLNLQA 576
               ::..|||:.:.|..|                 ::...:.:.:.|
Human   694 VRPAVPLLTQRGSGEARH-----------------HFPSLHTKAQLP------------------ 723

  Fly   577 IQKHQRERQQDLIQQQQ---IHTQAQNRMGKHVR----------WPGDLVQGEQVNPVILQSRRR 628
             ..|....|..::::|.   :.|:|.:..||.:|          .|.:|  ..:|.|.||:.|
Human   724 -SPHVLRHQGQVLRRQHSKLVGTKALSTTGKALRTLPTAKVFISLPPNL--DFKVAPSILKPR-- 783

  Fly   629 REEAEAYAKKHRALIAREIQRQKEQLLAPTCAKERLGIWQSVRREKRSQFSPKRGSSITKAYRRK 693
                     |..||:.    .:..||..|.|          :...|..||....|.|..||..|.
Human   784 ---------KAPALLC----LRGPQLEVPCC----------LCPLKSEQFLAPVGRSRPKANSRP 825

  Fly   694 QQRNLSLRARQQRMIEMEAQRDAKFLEQHAQKQRLEGGRKTGQSESPNLLSKITAKSKTSLKKKM 758
            ...  ..||....|..:...:....:... |::|..|..|.|         |...:..|:|....
Human   826 DCD--KPRAEACPMKRLSPLKPLPLVGTF-QRRRGLGDMKLG---------KPLLRFPTALVLDP 878

  Fly   759 KPKGKPELK---KETLQEGNHCQMTKSKVE----LTPGSKARA 794
            .|..|.::|   .:::..|.      |:|:    .||||.|||
Human   879 TPNKKKQVKYLGLDSIAVGG------SRVDGARPCTPGSTARA 915

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TTLL6A	NP_611433.3	TTL	181..471	CDD:397308	79/326 (24%)
TTLL3	NP_001021100.3	TTL	356..648	CDD:397308	80/342 (23%)