DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ir56d and GRIK2

DIOPT Version :9

Sequence 1:NP_611432.1 Gene:Ir56d / 37252 FlyBaseID:FBgn0034458 Length:632 Species:Drosophila melanogaster
Sequence 2:NP_068775.1 Gene:GRIK2 / 2898 HGNCID:4580 Length:908 Species:Homo sapiens


Alignment Length:682 Identity:115/682 - (16%)
Similarity:220/682 - (32%) Gaps:217/682 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 DNRAAELILRERN-------IFPTNGSDNITLLNNMFVLEMFYRITQLYHFKNFIFYISERLDLN 59
            |.:.|:.:|:|..       ||..:......:|.....:.|   :|:.||      ||...|||.
Human   207 DTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGM---MTEYYH------YIFTTLDLF 262

  Fly    60 NKDSQEFFHNFWTYFPMAPNLIITREHHLGIPMMQF-------ISTPSLVMVFT----------- 106
            ..|.:.:                   .:.|:.|..|       ....|::..::           
Human   263 ALDVEPY-------------------RYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPD 308

  Fly   107 TGKDDPIMEL-ASHNQQGIHWLKTIFVLFPSLQSRDFETNPESL----AQFTAEIKDVYDWVW-- 164
            :|..|..|.. |:.....:|.:......||.:.....:.|....    .:|.:.||:.:   |  
Human   309 SGLLDGFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQCNRHKPWRFGTRFMSLIKEAH---WEG 370

  Fly   165 -------------RKQFINTFLITIKDNVFILDPYPTPSIVNKTGVWQAEEFFHKYAKNMKG--- 213
                         |..| :..:|::|:..           :.|.|.|......: ..::.||   
Human   371 LTGRITFNKTNGLRTDF-DLDVISLKEEG-----------LEKIGTWDPASGLN-MTESQKGKPA 422

  Fly   214 ---------YLVRTPILYDMPRVF-KSDRPTNRYEKNFIHGTSGNL------FLGFLEFVNAT-- 260
                     .|:.|.||.:...:| |||:|.  |..:...|...:|      .|||...:...  
Human   423 NITDSLSNRSLIVTTILEEPYVLFKKSDKPL--YGNDRFEGYCIDLLRELSTILGFTYEIRLVED 485

  Fly   261 -------------------LMDTSANVTADYLNMTNLLDLV----------------------SQ 284
                               |:|..|::....|.:|.:.:.|                      :.
Human   486 GKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNGTNP 550

  Fly   285 GVYETLIHSFTEITTKFVVSYSYPIGINDCCIMV-----PYRNQSPADQYMHEALQENVWVLISL 344
            ||:..|.....:|....:::|   :|:: |.:.|     ||...:|........:.||.:.|::.
Human   551 GVFSFLNPLSPDIWMYILLAY---LGVS-CVLFVIARFSPYEWYNPHPCNPDSDVVENNFTLLNS 611

  Fly   345 FTLYITVAIYLCSPLRPRDLSAAFLQSICTLTYSVPTFIIRTPTLRMRYLYILLAIWGIVTSNLY 409
            |...:...:...|.|.|:.||...:..|.                   :.:.|:    |::|  |
Human   612 FWFGVGALMQQGSELMPKALSTRIVGGIW-------------------WFFTLI----IISS--Y 651

  Fly   410 ISRMTSYFTTAPPVRQINTVQDVVEANLRIKMLAIEYERMAKSPLQ--YPESYLNQVD------- 465
            .:.:.::.|.......|::..|:.      |...|||..:......  :.:|.::..|       
Human   652 TANLAAFLTVERMESPIDSADDLA------KQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMS 710

  Fly   466 ------LVDKHMLDLHRDPFNTSFGYTVSSDRWRFLNLQQLHLRKPIFRLTEICEGPFYHV-FPL 523
                  ||..:...:.| ...:.:.:.:.|....|:..:..:|.    ::..:.:...|.| .|:
Human   711 SRRQSVLVKSNEEGIQR-VLTSDYAFLMESTTIEFVTQRNCNLT----QIGGLIDSKGYGVGTPM 770

  Fly   524 HKDSHMRSVMTEYIMIAQQAGLMNHWERETFW 555
              .|..|..:|..|:..|:.|.: |..:|.:|
Human   771 --GSPYRDKITIAILQLQEEGKL-HMMKEKWW 799

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
Ir56dNP_611432.1 ATPase-IIIA_H <312..422 CDD:273731 20/114 (18%)
GRIK2NP_068775.1 PBP1_iGluR_Kainate 37..414 CDD:380605 40/250 (16%)
Periplasmic_Binding_Protein_Type_2 430..800 CDD:419667 73/415 (18%)
Glutamate binding. /evidence=ECO:0000250|UniProtKB:P42260 516..518 0/1 (0%)