DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hpo and OXSR1

DIOPT Version :9

Sequence 1:	NP_001261092.1	Gene:	hpo / 37247	FlyBaseID:	FBgn0261456	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	XP_011532633.1	Gene:	OXSR1 / 9943	HGNCID:	8508	Length:	580	Species:	Homo sapiens

Alignment Length:	486	Identity:	152/486 - (31%)
Similarity:	218/486 - (44%)	Gaps:	96/486 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 GEGSYGSV---YKAVHKESSSIVAIKLVPVESDLHEIIKEISIMQQCDSPYVVRYYGSYFKQYDL 110
            |.|:...|   |.|..||..:|..|.|...::.:.|::|||..|.||..|.:|.||.|:..:.:|
Human    77 GSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQCHHPNIVSYYTSFVVKDEL 141

  Fly   111 WICMEYCGAGSVSDIMR-------LRKKTLTEDEIATILSDTLQGLVYLHLRRKIHRDIKAANIL 168
            |:.|:....|||.||::       .:...|.|..|||||.:.|:||.|||...:||||:||.|||
Human   142 WLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVLEGLEYLHKNGQIHRDVKAGNIL 206

  Fly   169 LNTEGYAKLADFGVA------GQLTDTMAKRNTVIGTPFWMAPEVIEEI-GYDCVADIWSLGITA 226
            |..:|..::|||||:      |.:|.... |.|.:|||.||||||:|:: |||..|||||.||||
Human   207 LGEDGSVQIADFGVSAFLATGGDITRNKV-RKTFVGTPCWMAPEVMEQVRGYDFKADIWSFGITA 270

  Fly   227 LEMAEGKPPYGEIHPMRAIFMIPQKPPPSFREP-------DRWSTEFIDFVSKCLVKEPDDRATA 284
            :|:|.|..||.:..||:.:.:..|..|||....       .::...|...:|.||.|:|:.|.||
Human   271 IELATGAAPYHKYPPMKVLMLTLQNDPPSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTA 335

  Fly   285 TELLEHEFIRNAKHRSIL-KPMLEETCAIREQQRANRSFGGVLAASQAKSLATQENGMQQHITDN 348
            .|||.|:|.:.||::..| :..|:....|.|:.:..|...|    |..:...|::.|.:.  :|:
Human   336 AELLRHKFFQKAKNKEFLQEKTLQRAPTISERAKKVRRVPG----SSGRLHKTEDGGWEW--SDD 394

  Fly   349 AFME------------------------------DP-GTL--VPEKFGEYQQSSA-------SDA 373
            .|.|                              || |||  |||:...:....|       :..
Human   395 EFDEESEEGKAAISQLRSPRVKESISNSELFPTTDPVGTLLQVPEQISAHLPQPAGQIATQPTQV 459

  Fly   374 TMIAHAEQGVDEGTLGPGG--------------LRNLSK----------AAAPAAASSAASPLDM 414
            ::...||.......|..|.              |||..|          .....|...:...:..
Human   460 SLPPTAEPAKTAQALSSGSGSQETKIPISLVLRLRNSKKELNDIRFEFTPGRDTAEGVSQELISA 524

  Fly   415 PAVDSGTMVELESNLGTMVINSDSDDSTTAK 445
            ..||...:|.:.:||..:|....|:.|.|.|
Human   525 GLVDGRDLVIVAANLQKIVEEPQSNRSVTFK 555

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hpo	NP_001261092.1	STKc_MST1_2	38..293	CDD:132943	109/267 (41%)
		S_TKc	42..293	CDD:214567	109/267 (41%)
		Mst1_SARAH	608..655	CDD:288481
OXSR1	XP_011532633.1	STKc_OSR1_SPAK	77..344	CDD:270787	109/267 (41%)
OXSR1	XP_011532633.1	S_TKc	77..344	CDD:214567	109/267 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910