DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hpo and TAOK2

DIOPT Version :9

Sequence 1:	NP_001261092.1	Gene:	hpo / 37247	FlyBaseID:	FBgn0261456	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	XP_011544284.1	Gene:	TAOK2 / 9344	HGNCID:	16835	Length:	1242	Species:	Homo sapiens

Alignment Length:	784	Identity:	210/784 - (26%)
Similarity:	328/784 - (41%)	Gaps:	182/784 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 MKSPNISSSCSFFKLKKLSEESLLQPPEKVFDIMYKLGEGSYGSVYKAVHKESSSIVAIKLVPV- 75
            :|.|:::.  .|||          ..|||:|..:.::|.||:|:||.|....:|.:||||.:..
Human    10 LKDPDVAE--LFFK----------DDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYS 62

  Fly    76 ----ESDLHEIIKEISIMQQCDSPYVVRYYGSYFKQYDLWICMEYCGAGSVSDIMRLRKKTLTED 136
                .....:||||:..:|:...|..::|.|.|.:::..|:.|||| .||.||::.:.||.|.|.
Human    63 GKQSNEKWQDIIKEVRFLQKLRHPNTIQYRGCYLREHTAWLVMEYC-LGSASDLLEVHKKPLQEV 126

  Fly   137 EIATILSDTLQGLVYLHLRRKIHRDIKAANILLNTEGYAKLADFGVAGQLTDTMAKRNTVIGTPF 201
            |||.:....||||.|||....||||:||.||||:..|..||.|||.|    ..||..|:.:|||:
Human   127 EIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSA----SIMAPANSFVGTPY 187

  Fly   202 WMAPEVI---EEIGYDCVADIWSLGITALEMAEGKPPYGEIHPMRAIFMIPQKPPPSFREPDRWS 263
            |||||||   :|..||...|:||||||.:|:||.|||...::.|.|::.|.|...|.. :...||
Human   188 WMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPVL-QSGHWS 251

  Fly   264 TEFIDFVSKCLVKEPDDRATATELLEHEFIRNAKHRSILKPMLEET-CAIRE----QQRANRSF- 322
            ..|.:||..||.|.|.||.|:..||:|.|:...:..:::..:::.| .|:||    |.|..:..
Human   252 EYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRERPPTVIMDLIQRTKDAVRELDNLQYRKMKKIL 316

  Fly   323 --------------------------------GGVL---------------AASQAKSLAT---- 336
                                            .|.|               |:||:.|:.:
Human   317 FQEAPNGPGAEAPEEEEQPTPCSQEAEPYMHRAGTLTSLESSHSVPSMSISASSQSSSVNSLADA 381

  Fly   337 QENGMQQHITDNAFMEDPGTLVPE-------KFGEYQQSSASDATMIAHAEQGVD---------E 385
            .:|..::...:....|:.|   ||       :.||:..:|.|.   |.|...|.|         |
Human   382 SDNEEEEEEEEEEEEEEEG---PEAREMAMMQEGEHTVTSHSS---IIHRLPGSDNLYDDPYQPE 440

  Fly   386 GTLGPGGLRNLSKAAAPAAASSAASPLDMPAV---DSGTMVELESNLGTMVINSDSDDSTTAKNN 447
            .|..|     |...||||..|:.:|.......   |....:...|.:...:...:.|.:...:.:
Human   441 ITPSP-----LQPPAAPAPTSTTSSARRRAYCRNRDHFATIRTASLVSRQIQEHEQDSALREQLS 500

  Fly   448 DDQKPRNRYRPQFL-----------EH-------FDRKNAGDGRGDEKPIA--------TEYSPA 486
            ..::.|.:::.|.|           ||       .:.:.||.|...|| :|        .|...|
Human   501 GYKRMRRQHQKQLLALESRLRGEREEHSARLQRELEAQRAGFGAEAEK-LARRHQAIGEKEARAA 564

  Fly   487 AAEQQQQQQ-----------------------QQQQQQQQDEQHLASGANDLNNWEHNMEMQFQQ 528
            .||:::.||                       :::|.:::.:::.::...:...|....:.|.||
Human   565 QAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKEELQENPSTPKREKAEWLLRQKEQLQQ 629

  Fly   529 ISAINQYGLQQHQQQQQVLMAYPLMNEQLIALNNQPNLLLSN--AAPMGQQGIPAAAPAQPPPAY 591
            ..|..:.||.:.|:|...|.......:.|:|.::....||..  .....|:.:..|       ..
Human   630 CQAEEEAGLLRRQRQYFELQCRQYKRKMLLARHSLDQDLLREDLNKKQTQKDLECA-------LL 687

  Fly   592 QNQHMHTQSHAYVEGEFEFLKFLTFDDLNQRLCNIDHEMELEIEQLNKKYNAKRQPIVDAMNAKR 656
            ..||..|:       |.|..:..........|..:.|:.||. .||  :||.:|:..:...:|.:
Human   688 LRQHEATR-------ELELRQLQAVQRTRAELTRLQHQTELG-NQL--EYNKRREQELRQKHAAQ 742

  Fly   657 KRQQ 660
            .|||
Human   743 VRQQ 746

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hpo	NP_001261092.1	STKc_MST1_2	38..293	CDD:132943	114/262 (44%)
		S_TKc	42..293	CDD:214567	111/258 (43%)
		Mst1_SARAH	608..655	CDD:288481	10/46 (22%)
TAOK2	XP_011544284.1	STKc_TAO2	12..319	CDD:270804	125/324 (39%)
TAOK2	XP_011544284.1	S_TKc	28..281	CDD:214567	111/258 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910