DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hpo and SKM1

DIOPT Version :9

Sequence 1:	NP_001261092.1	Gene:	hpo / 37247	FlyBaseID:	FBgn0261456	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_014528.1	Gene:	SKM1 / 854036	SGDID:	S000005473	Length:	655	Species:	Saccharomyces cerevisiae

Alignment Length:	327	Identity:	108/327 - (33%)
Similarity:	176/327 - (53%)	Gaps:	32/327 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 VVDMKSPNISSSCSFFKLKKLSEESLLQPPEKVFDIMYKLGEGSYGSVYKA-------------- 59
            ::::|: |..|:....|:|.::.:   ..|...|.::.|.|:|:.|:||.:
Yeast   331 LLELKN-NDDSNEIIMKMKTVAID---VNPRPYFQLVEKAGQGASGAVYLSKRIKLPQENDPRFL 391

  Fly    60 ---VHKESSSIVAIKLVPVESDLHE--IIKEISIMQQCDSPYVVRYYGSY-FKQYDLWICMEYCG 118
               .|:.....||||.:.:.....:  |:.|:.:|.......:|.:..:| ....:||:.|||..
Yeast   392 KSHCHRVVGERVAIKQIRLSEQPKKQLIMNELLVMNDSRQENIVNFLEAYIIDDEELWVIMEYME 456

  Fly   119 AGSVSDIMR--LRKKT------LTEDEIATILSDTLQGLVYLHLRRKIHRDIKAANILLNTEGYA 175
            .|.::||:.  .|..|      |.|:::|.|:.:|.|||.:||.::.||||||:.|||||::|..
Yeast   457 GGCLTDILDAVARSNTGEHSSPLNENQMAYIVKETCQGLKFLHNKKIIHRDIKSDNILLNSQGLV 521

  Fly   176 KLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIEEIGYDCVADIWSLGITALEMAEGKPPYGEIH 240
            |:.|||...:||:..:||.|::|||:|||||::.:.|||...|:|||||..:||.||:|||....
Yeast   522 KITDFGFCVELTEKRSKRATMVGTPYWMAPEIVNQKGYDEKVDVWSLGIMLIEMIEGEPPYLNED 586

  Fly   241 PMRAIFMIPQKPPPSFREPDRWSTEFIDFVSKCLVKEPDDRATATELLEHEFIRNAKHRSILKPM 305
            |::|:::|.....|..|.|:..|.:...|:..||....:.||:..:||..||:..|.....||..
Yeast   587 PLKALYLIANNGSPKLRHPESVSKQTKQFLDACLQVNVESRASVRKLLTFEFLSMACSPEQLKVS 651

  Fly   306 LE 307
            |:
Yeast   652 LK 653

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hpo	NP_001261092.1	STKc_MST1_2	38..293	CDD:132943	98/282 (35%)
		S_TKc	42..293	CDD:214567	97/278 (35%)
		Mst1_SARAH	608..655	CDD:288481
SKM1	NP_014528.1	PH_Cla4_Ste20	4..113	CDD:270097
		PBD	122..180	CDD:395634
		STKc_PAK	359..640	CDD:270789	98/280 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910