DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hpo and BCK1

DIOPT Version :9

Sequence 1:	NP_001261092.1	Gene:	hpo / 37247	FlyBaseID:	FBgn0261456	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_012440.1	Gene:	BCK1 / 853350	SGDID:	S000003631	Length:	1478	Species:	Saccharomyces cerevisiae

Alignment Length:	318	Identity:	97/318 - (30%)
Similarity:	154/318 - (48%)	Gaps:	49/318 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 LGEGSYGSVYKAVHKESSSIVAIKL--VPVESDLHEII--------KEISIMQQCDSPYVVRYYG 102
            :|:||:|:||..::..:..::|:|.  ||..|..:|.|        .|:|.::..|...:|:|.|
Yeast  1181 IGKGSFGAVYLCLNVTTGEMMAVKQVEVPKYSSQNEAILSTVEALRSEVSTLKDLDHLNIVQYLG 1245

  Fly   103 SYFKQYDLWICMEYCGAGSVSDIMRLRKKTLTEDEIATILSDTLQGLVYLHLRRKIHRDIKAANI 167
            ...|.....:.:||...|||..::|:..: ..|..|..:.:..|:||.|||.:..:|||:||.|:
Yeast  1246 FENKNNIYSLFLEYVAGGSVGSLIRMYGR-FDEPLIKHLTTQVLKGLAYLHSKGILHRDMKADNL 1309

  Fly   168 LLNTEGYAKLADFGVAGQLTDTMAKRN-TVIGTPFWMAPEVIE-EIGYDCVADIWSLGITALEMA 230
            ||:.:|..|::|||::.:..|..:..: |:.||.||||||::: :.||....||||||...|||.
Yeast  1310 LLDQDGICKISDFGISRKSKDIYSNSDMTMRGTVFWMAPEMVDTKQGYSAKVDIWSLGCIVLEMF 1374

  Fly   231 EGKPPYGEIHPMRAIFM---------IPQKPPPSFREPDRWSTEFIDFVSKCLVKEPDDRATATE 286
            .||.|:..:..:.|:|.         ||:...|...:..|      :|:..|....|:.|.||.|
Yeast  1375 AGKRPWSNLEVVAAMFKIGKSKSAPPIPEDTLPLISQIGR------NFLDACFEINPEKRPTANE 1433

  Fly   287 LLEHEFIR-----NAKHRSILKPMLEETCAIREQQRANRSFGGVLAASQAKSLATQEN 339
            ||.|.|..     |.|...:.|       .|:...:.|         |....:.:|||
Yeast  1434 LLSHPFSEVNETFNFKSTRLAK-------FIKSNDKLN---------SSKLRITSQEN 1475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hpo	NP_001261092.1	STKc_MST1_2	38..293	CDD:132943	87/265 (33%)
		S_TKc	42..293	CDD:214567	87/265 (33%)
		Mst1_SARAH	608..655	CDD:288481
BCK1	NP_012440.1	STKc_Bck1_like	1173..1440	CDD:270799	87/265 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910