DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hpo and ATMAP4K ALPHA1

DIOPT Version :9

Sequence 1:	NP_001261092.1	Gene:	hpo / 37247	FlyBaseID:	FBgn0261456	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_001185209.1	Gene:	ATMAP4K ALPHA1 / 841750	AraportID:	AT1G53165	Length:	688	Species:	Arabidopsis thaliana

Alignment Length:	697	Identity:	206/697 - (29%)
Similarity:	310/697 - (44%)	Gaps:	133/697 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 LGEGSYGSVYKAVHKESSSIVAIKLVPV---ESDLHEIIKEISIMQQCDSPYVVRYYGSYFKQYD 109
            :|.||:|.||||...|.:..||||::.:   |.::.:|.||||::.||..||:..|||||..|..
plant    21 IGRGSFGDVYKAFDTELNKDVAIKVIDLEESEDEIEDIQKEISVLSQCRCPYITEYYGSYLHQTK 85

  Fly   110 LWICMEYCGAGSVSDIMRLRKKTLTEDEIATILSDTLQGLVYLHLRRKIHRDIKAANILLNTEGY 174
            |||.|||...|||:|::: ....|.|..||.|..|.|..:.|||...|||||||||||||:..|.
plant    86 LWIIMEYMAGGSVADLLQ-PGNPLDEISIACITRDLLHAVEYLHAEGKIHRDIKAANILLSENGD 149

  Fly   175 AKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIEEI-GYDCVADIWSLGITALEMAEGKPPYGE 238
            .|:|||||:.|||.|:::|.|.:|||||||||||:.. ||:..|||||||||.:|||:|:||..:
plant   150 VKVADFGVSAQLTRTISRRKTFVGTPFWMAPEVIQNSEGYNEKADIWSLGITMIEMAKGEPPLAD 214

  Fly   239 IHPMRAIFMIPQKPPPSFREPDRWSTEFIDFVSKCLVKEPDDRATATELLEHEFIRNAKHRSILK 303
            :||||.:|:||::.||...|  .:|....:|||.||.|.|.:|..|.|||:|.||:||:.    .
plant   215 LHPMRVLFIIPRESPPQLDE--HFSRPLKEFVSFCLKKAPAERPNAKELLKHRFIKNARK----S 273

  Fly   304 PMLEETCAIREQQRAN----------------RSFGGVLAASQAKSLATQENGMQQHITDNAFM- 351
            |.|.|  .|||:.:..                .|.|.|..|...:...|....:.:.: |..|.
plant   274 PKLLE--RIRERPKYQVKEDEEIPTNGPKAPAESSGTVRVAKDERGQGTSGTRLDKWL-DKCFQV 335

  Fly   352 ---------------EDPGT---LVPEKFGEYQQSSASDATMIAHAEQGVDEGTLGPGGLRNLSK 398
                           :..||   |.|.:..|.:|...|:.|                      |:
plant   336 KTVRNAGWDFSIGGSQGAGTVRALKPPQARERRQEVNSNQT----------------------SQ 378

  Fly   399 AAAPAAASSAASPLDMPAVDSGTMVELE------------SNLGTMVINSDSDDSTTAKNNDDQK 451
            ..:..:.|..:|...:|.:..|...:.:            |..||:||.|.....:::...|...
plant   379 KTSRTSGSQLSSTFGVPEISEGGFNKRDSYQNDYQEEDDSSGSGTVVIRSPRSSQSSSMFRDQSS 443

  Fly   452 PRNRYRPQFLEHFDRKNAGD----GRGDEKPIATEYSPAAAEQQQQQQQQQQQQQQD------EQ 506
            ...||    ....|...:|.    |:.|:..     ||.....:...|::.....:|      |.
plant   444 GSTRY----TSFDDASTSGTVVVRGQNDDSG-----SPRTPRSRLGLQERSSSASEDSISNLAEA 499

  Fly   507 HLA--------SGANDLNNWEHNMEMQFQQISAINQY--GLQQHQQQQQVLMAYPLMNEQLIALN 561
            .||        :....|.|.:.|...  :|.:..:.|  ..:.|..:|:     |:|..|.::.:
plant   500 KLALEAGFRRGNARERLGNGKVNKRR--EQATDNSDYLRNSRDHSDKQR-----PVMRSQQVSDD 557

  Fly   562 NQ-PNLLLSNAAPMGQQGIPAAAPAQPPPAYQNQHMHTQSHAYVEGEFE-------FLKFLTFDD 618
            .: .:.|.|.:|.:....:|:...|......:....|..|.:.|:.|.|       |:..|....
plant   558 EEDDSKLASLSASLSLLLLPSLKEAVGGDDSKGTIGHRVSRSLVKMEREKPGSSEAFIAKLIEQL 622

  Fly   619 LNQRLCNIDHEMELEIEQLNKKYNAKRQPIVDAMNAKRKRQQNINNN 665
            .:.:..::....::.|....|..|.      ||.|.:::..:..::|
plant   623 GSTKEVSVKEVQDMAIRVFAKTMNN------DAENKRKQASKEFSSN 663

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hpo	NP_001261092.1	STKc_MST1_2	38..293	CDD:132943	127/248 (51%)
		S_TKc	42..293	CDD:214567	127/248 (51%)
		Mst1_SARAH	608..655	CDD:288481	9/53 (17%)
ATMAP4K ALPHA1	NP_001185209.1	STKc_MST3_like	14..287	CDD:270786	137/274 (50%)
ATMAP4K ALPHA1	NP_001185209.1	S_TKc	19..267	CDD:214567	127/248 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D967913at2759
OrthoFinder	1	1.000	-	-		FOG0000324
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920