DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hpo and NP3

DIOPT Version :9

Sequence 1:	NP_001261092.1	Gene:	hpo / 37247	FlyBaseID:	FBgn0261456	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_187254.1	Gene:	NP3 / 819774	AraportID:	AT3G06030	Length:	651	Species:	Arabidopsis thaliana

Alignment Length:	604	Identity:	156/604 - (25%)
Similarity:	243/604 - (40%)	Gaps:	179/604 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 QPP--------EKVFDIMYKLGE----GSYGSVYKAVHKESSSIVAIKLVPV----------ESD 78
            :||        |:...|.::.||    |::|.||..::.:|..::|||.|.:          :..
plant    50 KPPPGLPAPRKEEAPSIRWRKGELIGCGAFGRVYMGMNLDSGELLAIKQVLIAPSSASKEKTQGH 114

  Fly    79 LHEIIKEISIMQQCDSPYVVRYYGSYFKQYDLWICMEYCGAGSVSDIMRLRKKTLTEDEIATILS 143
            :.|:.:|:.:::....|.:|||.|:..:...|.|.||:...||:|.::. :..:..|..|.....
plant   115 IRELEEEVQLLKNLSHPNIVRYLGTVRESDSLNILMEFVPGGSISSLLE-KFGSFPEPVIIMYTK 178

  Fly   144 DTLQGLVYLHLRRKIHRDIKAANILLNTEGYAKLADFGVAGQLTD--TMAKRNTVIGTPFWMAPE 206
            ..|.||.|||....:|||||.||||::.:|..:|||||.:.::.:  |:....::.|||:|||||
plant   179 QLLLGLEYLHNNGIMHRDIKGANILVDNKGCIRLADFGASKKVVELATVNGAKSMKGTPYWMAPE 243

  Fly   207 VIEEIGYDCVADIWSLGITALEMAEGKPPYGE-IHPMRAIFMI--PQKPPPSFREPDRWSTEFID 268
            ||.:.|:...|||||:|.|.:|||.||||:.| .....|:..|  .:..||.   |:..|.|..|
plant   244 VILQTGHSFSADIWSVGCTVIEMATGKPPWSEQYQQFAAVLHIGRTKAHPPI---PEDLSPEAKD 305

  Fly   269 FVSKCLVKEPDDRATATELLEHEFIRNAKH------------------------RSILKPML-EE 308
            |:.|||.|||..|.:|||||:|.|:...:.                        ||.:..:: ..
plant   306 FLMKCLHKEPSLRLSATELLQHPFVTGKRQEPYPAYRNSLTECGNPITTQGMNVRSSINSLIRRS 370

  Fly   309 TCA---------------IREQQRANRSFG-------------------------GVLAASQAKS 333
            ||:               |..|:..|..||                         .||  ||:..
plant   371 TCSGLKDVCELGSLRSSIIYPQKSNNSGFGWRDGDSDDLCQTDMDDLCNIESVRNNVL--SQSTD 433

  Fly   334 LATQENGMQQHITDN---AFMEDP---------------------------------GTLVPE-- 360
            |....|.|... |||   .|.|.|                                 |:.|.|
plant   434 LNKSFNPMCDS-TDNWSCKFDESPKVMKSKSNLLSYQASQLQTGVPCDEETSLTFAGGSSVAEDD 497

  Fly   361 ------KFGEYQQSSASDATMIA-------H--AEQGVDEGTLGPGGLRNLSKAAAPAAASSAAS 410
                  |...:....|.|...:.       |  ...|:.:|.||...:.||     |...|.:.:
plant   498 YKGTELKIKSFLDEKAQDLKRLQTPLLEEFHNAMNPGIPQGALGDTNIYNL-----PNLPSISKT 557

  Fly   411 PLDMP-----AVDSGTMVELESNLGTM----VINSDSD-----DSTTAKNNDDQ---KPRNRYRP 458
            |..:|     |:.......|:|:..|:    |:.|.::     :||....|:.:   :.|.::..
plant   558 PKRLPSRRLSAISDAMPSPLKSSKRTLNTSRVMQSGTEPTQVNESTKKGVNNSRCFSEIRRKWEE 622

  Fly   459 QFLEHFDR-----KNAGDG 472
            :..|..:|     ::||.|
plant   623 ELYEELERHRENLRHAGAG 641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hpo	NP_001261092.1	STKc_MST1_2	38..293	CDD:132943	100/281 (36%)
		S_TKc	42..293	CDD:214567	98/269 (36%)
		Mst1_SARAH	608..655	CDD:288481
NP3	NP_187254.1	STKc_MAPKKK	67..330	CDD:270783	97/266 (36%)
NP3	NP_187254.1	S_TKc	68..330	CDD:214567	97/265 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910