DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hpo and taok1

DIOPT Version :9

Sequence 1:	NP_001261092.1	Gene:	hpo / 37247	FlyBaseID:	FBgn0261456	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_001116260.1	Gene:	taok1 / 733788	XenbaseID:	XB-GENE-956111	Length:	1001	Species:	Xenopus tropicalis

Alignment Length:	771	Identity:	211/771 - (27%)
Similarity:	321/771 - (41%)	Gaps:	197/771 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 PEVTSVVDMKSPNISSSCSFFKLKKLSEESLLQPPEKVFDIMYKLGEGSYGSVYKAVHKESSSIV 68
            |..:....:|.|:|:.  .||:          ..|||:|..:.::|.||:|:||.|....:|.:|
Frog     2 PSTSRAGSLKDPDIAE--LFFR----------DDPEKLFSDLREIGHGSFGAVYFAHDARTSEVV 54

  Fly    69 AIKLVPV-----ESDLHEIIKEISIMQQCDSPYVVRYYGSYFKQYDLWICMEYCGAGSVSDIMRL 128
            |||.:..     .....:||||:..:|:...|..:.|.|.|.:::..|:.|||| .||.||::.:
Frog    55 AIKKMSYSGKQSNEKWQDIIKEVKFLQRIKHPNSIEYKGCYLREHTAWLVMEYC-LGSASDLLEV 118

  Fly   129 RKKTLTEDEIATILSDTLQGLVYLHLRRKIHRDIKAANILLNTEGYAKLADFGVAGQLTDTMAKR 193
            .||.|.|.|||.|....||||.|||....|||||||.||||...|..||||||.|    ..::..
Frog   119 HKKPLQEIEIAAITHGALQGLAYLHSHNLIHRDIKAGNILLTEPGQVKLADFGSA----SIVSPA 179

  Fly   194 NTVIGTPFWMAPEVI---EEIGYDCVADIWSLGITALEMAEGKPPYGEIHPMRAIFMIPQKPPPS 255
            |:.:|||:|||||||   :|..||...|:||||||.:|:||.|||...::.|.|::.|.|...|:
Frog   180 NSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPT 244

  Fly   256 FREPDRWSTEFIDFVSKCLVKEPDDRATATELLEHEFIRNAKHRSILKPMLEET-CAIREQQRAN 319
            . :.:.||..|.:||..||.|.|.||.|:.|||:|.|:...:..::|..:::.| .|:||...
Frog   245 L-QSNEWSDYFRNFVDSCLQKIPQDRPTSDELLKHMFVLRERPETVLIDLIQRTKDAVRELDN-- 306

  Fly   320 RSFGGVLAASQAKSLATQE--NGMQQHITDNAFMEDPGTLVPEKFGEYQQSSASDATMIAHAEQG 382
                  |...:.|.|..||  ||             |.....|:  |.:|            |.|
Frog   307 ------LQYRKMKKLLFQEAHNG-------------PAVETQEE--EEEQ------------EHG 338

  Fly   383 VDE-GTLGPGGLRNLSKAAAPAAASSAASPLDMP-AVDSGTMVELESNLGTMVINSD-------- 437
            |.. ||:...|......:.:.:|:|.::|...:| |.|..:.:::.....|::.||.
Frog   339 VGRTGTVNSIGSNQSIPSMSISASSQSSSVNSLPDASDDKSELDMMEGDHTVMSNSSVIHLKPEE 403

  Fly   438 ----SDDSTTAKNNDDQKP------RNRYRPQFLEHFDRKNAGDGRGDEKPIATEYSPAAAEQQQ 492
                .:....|:.::.|.|      ::.||.:  |||               ||..:.:...:|.
Frog   404 ESYPEEPEPRARPSEPQSPPQVSRHKSHYRNR--EHF---------------ATIRTASLVTRQI 451

  Fly   493 QQQQQ---------------QQQQQQ------------DEQHLASGANDLNNWEHNMEMQFQQIS 530
            |:.:|               :|.|:|            ||..|... .||....:|...:.:::.
Frog   452 QEHEQDSELREQMSGYKRMRRQHQKQLMALENKLKAEMDEHRLRLD-KDLETQRNNFAAEMEKLV 515

  Fly   531 AINQYGL--------------QQHQQQQQ----------VLMAYPLMNEQLIALNNQPNLLLSNA 571
            ..:|..:              |||.|.||          ....|.|..|||....|:..
Frog   516 KKHQAAMEKELKLMANEEKKFQQHIQAQQKKELNSFLESQKREYKLRKEQLKEELNENQ------ 574

  Fly   572 APMGQQGIPAAAPAQPPPAYQNQHMHTQSHAYVEGEFEFLK----FLTFD--DLNQRLCNIDHEM 630
                      :.|.:....:.::......|...|.|...|:    :|..:  ...:|:....|.:
Frog   575 ----------STPKKEKQEWLSKQKENFQHFQAEEEANLLRRQRQYLELECRRFKRRMLLSRHNL 629

  Fly   631 ELEI--EQLNKKYNAKRQPIVDAMNAKRKRQ---------------QNINNNLIKI 669
            |.::  |:|||:...|     |..:|...||               |.:...|||:
Frog   630 EQDLVREELNKRQTQK-----DLEHAMLLRQHESMQELEFRHLNTIQRMRCELIKL 680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hpo	NP_001261092.1	STKc_MST1_2	38..293	CDD:132943	116/262 (44%)
		S_TKc	42..293	CDD:214567	113/258 (44%)
		Mst1_SARAH	608..655	CDD:288481	11/54 (20%)
taok1	NP_001116260.1	STKc_TAO1	2..318	CDD:270805	131/341 (38%)
taok1	NP_001116260.1	SbcC	<444..>876	CDD:223496	47/259 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910