DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hpo and Stk26

DIOPT Version :9

Sequence 1:	NP_001261092.1	Gene:	hpo / 37247	FlyBaseID:	FBgn0261456	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_598490.1	Gene:	Stk26 / 70415	MGIID:	1917665	Length:	416	Species:	Mus musculus

Alignment Length:	392	Identity:	158/392 - (40%)
Similarity:	229/392 - (58%)	Gaps:	49/392 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 PEKVFDIMYKLGEGSYGSVYKAVHKESSSIVAIKLVPV---ESDLHEIIKEISIMQQCDSPYVVR 99
            ||::|..:.::|:||:|.|:|.:...:..:||||::.:   |.::.:|.:||:::.||||.||.:
Mouse    20 PEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSSYVTK 84

  Fly   100 YYGSYFKQYDLWICMEYCGAGSVSDIMRLRKKTLTEDEIATILSDTLQGLVYLHLRRKIHRDIKA 164
            |||||.|...|||.|||.|.||..|:  ||.....|.:|||:|.:.|:||.|||..:||||||||
Mouse    85 YYGSYLKGSKLWIIMEYLGGGSALDL--LRAGPFDEFQIATMLKEILKGLDYLHSEKKIHRDIKA 147

  Fly   165 ANILLNTEGYAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIEEIGYDCVADIWSLGITALEM 229
            ||:||:.:|..||||||||||||||..||||.:|||||||||||::..||..||||||||||:|:
Mouse   148 ANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDSKADIWSLGITAIEL 212

  Fly   230 AEGKPPYGEIHPMRAIFMIPQKPPPSFREPDRWSTEFIDFVSKCLVKEPDDRATATELLEHEFI- 293
            |:|:||..::||||.:|:||:..||:.  ...::..|.:|:..||.|:|..|.||.|||:|:||
Mouse   213 AKGEPPNSDMHPMRVLFLIPKNNPPTL--IGDFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIV 275

  Fly   294 RNAKHRSILKPMLE----------------------ETCAIREQQRANRSFGGVLAASQAKSLAT 336
            :|:|..|.|..:::                      |:.:.........||..|......|.|
Mouse   276 KNSKKTSYLTELIDRFKRWKAEGHSDEESDSEGSDSESSSRESNPHPEWSFTTVRKKPDPKKL-- 338

  Fly   337 QENGMQQHITDNAFMEDPGTLVPEKFGEYQQSSASDATMIAHAEQGVDEGTLGPGGLRNLSKAAA 401
             :||.:|.:...  :.....::...|.|.:|...::|:    ..|.::|          |.|:.|
Mouse   339 -QNGEEQDLVQT--LSCLSMIITPAFAELKQQDENNAS----RNQAIEE----------LEKSIA 386

  Fly   402 PA 403
            .|
Mouse   387 VA 388

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hpo	NP_001261092.1	STKc_MST1_2	38..293	CDD:132943	133/257 (52%)
		S_TKc	42..293	CDD:214567	131/253 (52%)
		Mst1_SARAH	608..655	CDD:288481
Stk26	NP_598490.1	STKc_MST4	19..295	CDD:132971	139/278 (50%)
		S_TKc	24..274	CDD:214567	131/253 (52%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	296..343		8/49 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D967913at2759
OrthoFinder	1	1.000	-	-		FOG0000324
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920