Protein Alignment hpo and STK4

DIOPT Version :9

• Sequence 1: NP_001261092.1
• Gene: hpo / 37247
• FlyBaseID: FBgn0261456
• Length: 669
• Species: Drosophila melanogaster
• Sequence 2: XP_005260587.1
• Gene: STK4 / 6789
• HGNCID: 11408
• Length: 503
• Species: Homo sapiens
• Alignment Length: 666
• Identity: 302/666 - (45%)
• Similarity: 375/666 - (56%)
• Gaps: 191/666 - (28%)

  Fly     2 SEPEVTSVVDMKSPNISSSCSFFKLKKLSEESLLQPPEKVFDIMYKLGEGSYGSVYKAVHKESSS 66
            |||::..                :||||.|:||.:.||:|||::.|||||||||||||:|||:..
Human    22 SEPDIGR----------------QLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQ 70

  Fly    67 IVAIKLVPVESDLHEIIKEISIMQQCDSPYVVRYYGSYFKQYDLWICMEYCGAGSVSDIMRLRKK 131
            |||||.|||||||.|||||||||||||||:||:|||||||..||||.||||||||||||:|||.|
Human    71 IVAIKQVPVESDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNK 135

  Fly   132 TLTEDEIATILSDTLQGLVYLHLRRKIHRDIKAANILLNTEGYAKLADFGVAGQLTDTMAKRNTV 196
            |||||||||||..||:||.|||..|||||||||.||||||||:||||||||||||||||||||||
Human   136 TLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTV 200

  Fly   197 IGTPFWMAPEVIEEIGYDCVADIWSLGITALEMAEGKPPYGEIHPMRAIFMIPQKPPPSFREPDR 261
            ||||||||||||:||||:||||||||||||:|||||||||.:|||||||||||..|||:||:|:.
Human   201 IGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPEL 265

  Fly   262 WSTEFIDFVSKCLVKEPDDRATATELLEHEFIRNAKHRSILKPMLEETCAIREQQRANRSFGGVL 326
            ||..|.|||.:||||.|:.|||||:||:|.|:|:||..|||:.::.|...::
Human   266 WSDNFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKGVSILRDLINEAMDVK------------- 317

  Fly   327 AASQAKSLATQENGMQQHITDNAFMEDPGTLVPEKFGEYQQSSASDATMIAHAEQGVDEGTLGPG 391
                   |..||:  ||...|.               :.:::|..|.         :|.||:
Human   318 -------LKRQES--QQREVDQ---------------DDEENSEEDE---------MDSGTM--- 346

  Fly   392 GLRNLSKAAAPAAASSAASPLDMPAVDSGTMVE----LESNLGTMVINS-DSDDSTTAKNNDD-Q 450
             :|.:.........:|..:.      .:.||:|    |.|.|||||||: |.::..|.|..|: .
Human   347 -VRAVGDEMGTVRVASTMTD------GANTMIEHDDTLPSQLGTMVINAEDEEEEGTMKRRDETM 404

  Fly   451 KPRNRYRPQFLEHFDRKNAGDGRGDEKPIATEYSPAAAEQQQQQQQQQQQQQQDEQHLASGANDL 515
            :|.   :|.|||:|                        ||::::.|
Human   405 QPA---KPSFLEYF------------------------EQKEKENQ------------------- 423

  Fly   516 NNWEHNMEMQFQQISAINQYGLQQHQQQQQVLMAYPLMNEQLIALNNQPNLLLSNAAPMGQQGIP 580
                            ||.:|..         :..||.|.                   ....||
Human   424 ----------------INSFGKS---------VPGPLKNS-------------------SDWKIP 444

  Fly   581 AAAPAQPPPAYQNQHMHTQSHAYVEGEFEFLKFLTFDDLNQRLCNIDHEMELEIEQLNKKYNAKR 645
            .                       :|::||||..|.:||.:||..:|..||.|||::.:||.:||
Human   445 Q-----------------------DGDYEFLKSWTVEDLQKRLLALDPMMEQEIEEIRQKYQSKR 486

  Fly   646 QPIVDAMNAKRKRQQN 661
            |||:||:.||::||||
Human   487 QPILDAIEAKKRRQQN 502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hpo	NP_001261092.1	STKc_MST1_2	38..293	CDD:132943	207/254 (81%)
		S_TKc	42..293	CDD:214567	204/250 (82%)
		Mst1_SARAH	608..655	CDD:288481	24/46 (52%)
STK4	XP_005260587.1	STKc_MST1_2	42..297	CDD:132943	207/254 (81%)
		S_TKc	46..297	CDD:214567	204/250 (82%)
		Mst1_SARAH	449..496	CDD:288481	24/46 (52%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	426	1.000	Domainoid score	I608
eggNOG	1	0.900	-	-		E1_KOG0574
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	550	1.000	Inparanoid score	I1142
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D247842at33208
OrthoFinder	1	1.000	-	-		FOG0000324
OrthoInspector	1	1.000	-	-		otm42246
orthoMCL	1	0.900	-	-		OOG6_102280
Panther	1	1.100	-	-	O	PTHR48015
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4601
SonicParanoid	1	1.000	-	-		X1715
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.860